Dissociable roles of the mPFC-to-VTA Pathway in the control of iImpulsive Action and Risk-Related Decision-Making in Roman High- And Low-Avoidance Rats DOI Open Access
Ginna Urueña‐Méndez, Chloé Arrondeau,

Florian Marchessaux

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 14, 2024

Abstract Impulsivity is a multidimensional trait associated with various psychiatric disorders including drug abuse. facets, such as impulsive action and risk-related decision-making (RDM), have been reduced frontocortical activity alterations in dopamine function the ventral tegmental area (VTA). However, despite direct projections from medial prefrontal cortex (mPFC) to VTA, specific role of mPFC-to-VTA pathway control behaviors remains unexplored. Here, we used Positron Emission Tomography [ 18 F]-Fluorodeoxyglucose evaluate brain metabolic Roman High-(RHA) Low-avoidance (RLA) rats, which exhibit innate differences impulsivity. Notably, viral-based intersectional chemogenetic strategy isolate, for first time, controlling behaviors. We selectively activated RHAs inhibited it RLAs, assessed effects on RDM rat gambling task. Our results showed that RHA rats displayed higher action, less optimal decision-making, lower cortical than RLA at baseline. Chemogenetic activation RHAs, whereas inhibition had opposite effect RLAs. these manipulations did not affect RDM. Thus, by specifically bidirectionally targeting phenotype-dependent way, were able revert patterns but findings suggest dissociable RDM, highlighting its potential target investigating impulsivity-related disorders.

Язык: Английский

Brain circuits that regulate social behavior DOI Creative Commons
Hao Li, Zhe Zhao,

Shaofei Jiang

и другие.

Molecular Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Social interactions are essential for the survival of individuals and reproduction populations. stressors, such as social defeat isolation, can lead to emotional disorders cognitive impairments. Furthermore, dysfunctional behaviors hallmark symptoms various neuropsychiatric disorders, including autism spectrum disorder (ASD) post-traumatic stress (PTSD). Consequently, understanding neural circuit mechanisms underlying has become a major focus in neuroscience. behaviors, which encompass wide range expressions phases, regulated by complex networks. In this review, we summarize recent progress identifying circuits involved different types general investigation, preference, mating, aggression, parenting, prosocial dominance behaviors. We also outline associated with deficits ASD, schizophrenia, PTSD. Given pivotal role rodents behavior research, our review primarily focuses on these animals. Finally, propose future research directions, development specific behavioral paradigms, identification motor output, integration activity, transcriptome, connectome data, multifunctional roles neurons multiple targets, among brain regions.

Язык: Английский

Процитировано

0
Dissociable roles of the mPFC-to-VTA Pathway in the control of Impulsive Action and Risk-Related Decision-Making in Roman High- And Low-Avoidance Rats DOI Creative Commons
Ginna Urueña‐Méndez, Chloé Arrondeau,

Florian Marchessaux

и другие.

The International Journal of Neuropsychopharmacology, Год журнала: 2024, Номер 27(10)

Опубликована: Авг. 15, 2024

Abstract Background Impulsive action and risk-related decision-making (RDM) are associated with various psychiatric disorders, including drug abuse. Both behavioral traits have also been linked to reduced frontocortical activity alterations in dopamine function the ventral tegmental area (VTA). However, despite direct projections from medial prefrontal cortex (mPFC) VTA, specific role of mPFC-to-VTA pathway controlling impulsive RDM remains unexplored. Methods We used positron emission tomography [18F]-fluorodeoxyglucose evaluate brain metabolic Roman high- (RHA) low-avoidance (RLA) rats, which exhibit innate differences RDM. Notably, we a viral-based double dissociation chemogenetic strategy isolate, for first time our knowledge, these behaviors. selectively activated RHA rats inhibited it RLA assessing effects on rat gambling task. Results Our results showed that displayed higher action, less optimal decision-making, lower cortical than at baseline. Chemogenetic activation whereas inhibition had opposite effect rats. manipulations did not affect Thus, by specifically targeting phenotype-dependent way, reverted patterns but Conclusion findings suggest dissociable RDM, highlighting its potential as target investigating impulsivity-related disorders.

Язык: Английский

Процитировано

1
The role of the prefrontal cortex in modulating aggression in humans and rodents DOI
Xinyang Li, Lize Xiong, Yan Li

и другие.

Behavioural Brain Research, Год журнала: 2024, Номер unknown, С. 115285 - 115285

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

1
Transcriptional programming of social hierarchy DOI Creative Commons
Yoh Isogai

Neuron, Год журнала: 2024, Номер 112(4), С. 523 - 525

Опубликована: Фев. 1, 2024

Язык: Английский

Процитировано

0
Mesocorticolimbic circuit mechanisms of social dominance behavior DOI Creative Commons
Tae-Yong Choi, Se‐Jin Jeong, Ja Wook Koo

и другие.

Experimental & Molecular Medicine, Год журнала: 2024, Номер 56(9), С. 1889 - 1899

Опубликована: Сен. 2, 2024

Abstract Social animals, including rodents, primates, and humans, partake in competition for finite resources, thereby establishing social hierarchies wherein an individual’s standing influences diverse behaviors. Understanding the neurobiological underpinnings of dominance is imperative, given its ramifications health, survival, reproduction. behavior comprises several facets, recognition, decision-making, actions, indicating concerted involvement multiple brain regions orchestrating this behavior. While extensive research has been dedicated to elucidating neurobiology interaction, recent studies have increasingly delved into adverse behaviors such as hierarchy. This review focuses on latest advancements comprehending mechanisms mesocorticolimbic circuit governing dominance, with a specific focus rodent studies, intricate dynamics their implications individual well-being adaptation.

Язык: Английский

Процитировано

0
Oxytocin receptor controls distinct components of pair bonding and development in prairie voles DOI
Ruchira Sharma, Kristen M. Berendzen, Amanda Everitt

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 26, 2024

Oxytocin receptor (Oxtr) signaling influences complex social behaviors in diverse species, including monogamy prairie voles. How Oxtr regulates specific components of attachment and the neural mechanisms mediating them remains unknown. Here, we examine voles lacking demonstrate that pair bonding comprises distinct behavioral modules: preference for a bonded partner, rejection novel potential mates. Our longitudinal study shows sex-specifically early interactions between partners facilitating formation partner preference. Additionally, suppresses promiscuity towards mates following bonding, contributing to rejection. function coordinated patterns gene expression regions implicated oxytocin paraventricular nucleus hypothalamus, principal source oxytocin. Thus, controls genetically separable coordinates development substrates attachment.

Язык: Английский

Процитировано

0
Dissociable roles of the mPFC-to-VTA Pathway in the control of iImpulsive Action and Risk-Related Decision-Making in Roman High- And Low-Avoidance Rats DOI Open Access
Ginna Urueña‐Méndez, Chloé Arrondeau,

Florian Marchessaux

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 14, 2024

Abstract Impulsivity is a multidimensional trait associated with various psychiatric disorders including drug abuse. facets, such as impulsive action and risk-related decision-making (RDM), have been reduced frontocortical activity alterations in dopamine function the ventral tegmental area (VTA). However, despite direct projections from medial prefrontal cortex (mPFC) to VTA, specific role of mPFC-to-VTA pathway control behaviors remains unexplored. Here, we used Positron Emission Tomography [ 18 F]-Fluorodeoxyglucose evaluate brain metabolic Roman High-(RHA) Low-avoidance (RLA) rats, which exhibit innate differences impulsivity. Notably, viral-based intersectional chemogenetic strategy isolate, for first time, controlling behaviors. We selectively activated RHAs inhibited it RLAs, assessed effects on RDM rat gambling task. Our results showed that RHA rats displayed higher action, less optimal decision-making, lower cortical than RLA at baseline. Chemogenetic activation RHAs, whereas inhibition had opposite effect RLAs. these manipulations did not affect RDM. Thus, by specifically bidirectionally targeting phenotype-dependent way, were able revert patterns but findings suggest dissociable RDM, highlighting its potential target investigating impulsivity-related disorders.

Язык: Английский

Процитировано

0