Physio-fUS: a tissue-motion based method for heart and breathing rate assessment in neurofunctional ultrasound imaging
EBioMedicine,
Год журнала:
2025,
Номер
112, С. 105581 - 105581
Опубликована: Янв. 31, 2025
Язык: Английский
Brainwide genetic capture for conscious state transitions
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Summary
Abstract
Spatially
integrated
mechanisms
of
consciousness
are
unclear
1,2
.
An
approach
to
manipulate
brainwide
circuits
regulating
via
synthetic
central
nervous
system
activation
may
pave
the
way
for
more
precise
transitions
in
and
reveal
underlying
mechanisms.
Toward
this
goal,
we
leverage
anesthesia
as
a
tool
probe
at
cellular
resolution
within
intact
network.
We
perform
chemogenetic
capture
3,4
isoflurane
anesthesia-activated
circuitry
mice
—in
parallel
with
electrocorticography
5
,
wireless
mechano-
acoustic
recording
peripheral
physiology
6
behavioral
classification
7,8
—
describe
state
altered
generated
absence
an
anesthetic
agent.
define
patterns
under
using
brain
immediate
early
gene
mapping
9–12
combined
high
density
silicon
recordings
13
Our
data
identify
subcortical
hotspots
neural
activity
unconsciousness
network
that
is
globally
characterized
by
increased
functional
connectivity
driven
select
nodes.
provide
technical
resources
spanning
single-cell
maps
neurophysiologic
datasets
isoflurane-rendered
unconscious
state,
along
further
its
global
cellular-level
Together,
present
foundation
future
research
refine
viral-genetic
generate
conscious
transitions,
such
sleep,
stasis,
analgesia
or
anesthesia.
Язык: Английский
Implantable bioelectronics and wearable sensors for kidney health and disease
Nature Reviews Nephrology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 29, 2025
Язык: Английский
Monolithically Defined Wireless Fully Implantable Nervous System Interfaces
Accounts of Chemical Research,
Год журнала:
2024,
Номер
57(9), С. 1275 - 1286
Опубликована: Апрель 12, 2024
ConspectusEvolution
of
implantable
neural
interfaces
is
critical
in
addressing
the
challenges
understanding
fundamental
working
principles
and
therapeutic
applications
for
central
peripheral
nervous
systems.
Traditional
approaches
utilizing
hermetically
sealed,
rigid
electronics
detached
electrodes
face
power
supply,
encapsulation,
channel
count,
dispersed
application
location,
modality.
Employing
thin-film,
wirelessly
powered
devices
promising
to
expand
capabilities.
Devices
that
forego
bulky
supplies,
favoring
a
configuration
where
are
integrated
directly
onto
thin
films,
reduce
displacement
volumes
seamless,
fully
with
high
energy
availability
soft
mechanics
conform
neuronal
target.
We
discuss
3
device
architectures:
(1)
Highly
miniaturized
merge
into
single,
injectable
format;
(2)
Interfaces
consolidate
power,
computation,
connectivity
on
sheet
applied
target
area;
(3)
A
spatially
dislocated
approach
computation
situated
subdermally,
connected
via
interconnect
interface.Each
has
advantages
constraints
terms
implantation
invasiveness,
capturing
efficiency,
directional
sensitivity
delivery.
In
powering
these
devices,
near-field
delivery
emerges
as
most
implemented
technique.
Key
parameters
size
volume
primary
secondary
antennas,
which
determine
coupling
efficiency
Based
requirements,
ranging
from
small
large
animal
models,
subjects
require
system
level
designs.
Material
strategies
play
crucial
role;
monolithic
designs,
materials
like
polyimide
substrates,
enable
scalability
performance.
This
contrasts
established
hermetic
encapsulation
use
stainless
steel
or
titanium
box
passthroughs
result
tissue
displacements
prohibit
intimate
integration
organ
Encapsulation,
particularly
parylene,
enables
longevity
effectiveness;
more
research
needed
human
lifetime
operation.
Implant-to-ambient
communication,
focusing
compatible
well-established
standards
off-the-shelf
electronics,
discussed
goal
enabling
seamless
integration,
reliability,
scalability.
The
interface
explored
through
various
wireless,
battery-free
capable
both
stimulation
(electrical
optogenetic)
recording
(photometric
electrochemical).
These
show
advanced
capabilities
chronic
studies
insights
dynamics.
system,
applications,
such
spinal
muscle
stimulation,
discussed.
lie
mechanical
electrochemical
durability.
Examples
successfully
navigate
offer
solutions
this
domain.
potential
using
near
field
resonant
transfer
characterized
by
monolithically
defined
architecture,
providing
significant
leap
toward
access
New
avenues
supporting
multimodal
multisite
neuromodulation
degree
holistic
deciphering
supplementing
may
recovery
treatment
injury
disease.
Язык: Английский
A Mechanics and Electromagnetic Scaling Law for Highly Stretchable Radio Frequency Electronics
Journal of the Mechanics and Physics of Solids,
Год журнала:
2024,
Номер
191, С. 105784 - 105784
Опубликована: Июль 14, 2024
Язык: Английский
Advanced flexible brain‐computer interfaces and devices for the exploration of neural dynamics
Brain‐X,
Год журнала:
2024,
Номер
2(4)
Опубликована: Дек. 1, 2024
Abstract
The
rapid
advancement
of
flexible
neural
interfaces
and
devices
is
revolutionizing
our
ability
to
explore
the
foundations
consciousness,
intelligence,
behavior.
Cutting‐edge
developments
in
materials
science
system‐level
integration
are
significantly
enhancing
spatiotemporal
resolution
signal
acquisition
modulation,
paving
way
for
next‐generation
brain‐computer
interfaces.
These
technologies
enable
unprecedented
investigations
into
causal
relationships
between
dynamics
behaviors
freely
moving
subjects,
offering
new
insights
various
neurocognitive
domains.
artificial
intelligence
brain
organoids
with
neuroscience
research
promises
further
decode
complex
signals,
deepening
understanding
multilevel
dynamics.
Beyond
their
scientific
implications,
these
innovations
also
offer
transformative
possibilities
diagnosis,
treatment,
management
neurological
psychiatric
disorders.
This
perspective
paper
examines
how
overcome
limitations
traditional
neurotechnology,
potential
impact
on
research,
promising
applications
treating
disorders,
while
considering
ethical
implications
future
challenges
this
rapidly
evolving
field.
Язык: Английский
A Mechanics and Electromagnetic Scaling Law for Highly Stretchable Radio Frequency Electronics
Опубликована: Янв. 1, 2024
Язык: Английский
Wireless, Multimodal Monitoring of Organ Health Using 3D-Printed, Barbed, Bioresorbable Stretchable Microneedle Sensor Arrays
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 18, 2024
Comprehensive
and
continuous
assessment
of
organ
physiology
biochemistry,
beyond
the
capabilities
conventional
monitoring
tools,
can
enable
timely
interventions
for
intraoperative
complications
like
ischemia
nerve
injuries
postoperative
conditions
such
as
dysfunction
transplant
rejection.
Here,
we
report
a
wireless
implant
with
3D-printed,
barbed,
bioresorbable
stretchable
microneedle
sensor
array
that
offers
multimodal
metabolism,
oxygenation,
electrophysiology
well
spatiotemporal
mapping
biomarkers
across
different
regions.
The
development
deformation-coupled
3D-printing
technique
enables
3D-programmable
manufacturing
microneedles
monolithic
backward-facing
barbs,
offering
conformal
yet
robust
3D
probing
organs
dynamic
mechanics.
Electrochemical
functionalization
tips
serves
universal
approach
localized
sensing
physiological
biochemical
parameters,
enabling
concurrent
up
to
36
parameters
(glucose,
uric
acid,
oxygen,
etc.
)
32
sites.
An
electrically
programmable
self-destruction
mechanism
based
on
crevice
corrosion
bioresorption
eliminates
need
traumatic
retrieval
microneedles.
Demonstrations
in
clinically
relevant
kidney
gut
disorders
animal
models
highlight
broad
applications
this
device
intra-
monitoring.
Язык: Английский
Sunflower-like self-sustainable plant-wearable sensing probe
Shuang Wang,
Yangfan Chai,
Huiwen Sa
и другие.
Science Advances,
Год журнала:
2024,
Номер
10(49)
Опубликована: Дек. 4, 2024
Powering
and
communicating
with
wearable
devices
on
bio-interfaces
is
challenging
due
to
strict
weight,
size,
resource
constraints.
This
study
presents
a
sunflower-like
plant-wearable
sensing
device
that
harnesses
solar
energy,
achieving
complete
energy
self-sustainability
for
long-term
monitoring
of
plant
sap
flow,
crucial
indicator
health.
It
features
foldable
panels
along
all
essential
flexible
electronic
components,
resulting
in
compact
system
lightweight
enough
small
plants.
To
tackle
the
low-energy
density
power,
we
developed
an
ultralow-energy
light
communication
mechanism
inspired
by
fireflies.
Together
unmanned
aerial
vehicles
deep
learning
algorithms,
this
approach
enables
efficient
data
retrieval
from
multiple
across
large
agricultural
fields.
With
its
simple
deployment,
it
shows
great
potential
as
low-cost
phenotyping
tool.
We
believe
our
solution
can
be
extended
similar
resource-limited
scenarios,
leading
exciting
applications.
Язык: Английский