bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 30, 2024
Dystroglycan
is
a
cell
adhesion
molecule
that
localizes
to
synapses
throughout
the
nervous
system.
While
required
maintain
inhibitory
from
cerebellar
molecular
layer
interneurons
(MLIs)
onto
Purkinje
cells
(PCs)
whether
initial
synaptogenesis
during
development
dependent
on
has
not
been
examined.
We
show
conditional
deletion
of
BMC Bioinformatics,
Год журнала:
2024,
Номер
25(1)
Опубликована: Дек. 18, 2024
Recent
developments
in
spatially
resolved
transcriptomics
(SRT)
enable
the
characterization
of
spatial
structures
for
different
tissues.
Many
decomposition
methods
have
been
proposed
to
depict
cellular
distribution
within
However,
existing
computational
struggle
balance
continuity
cell
with
preservation
cell-specific
characteristics.
To
address
this,
we
propose
Spall,
a
novel
network
that
integrates
scRNA-seq
data
SRT
accurately
infer
type
proportions.
Spall
introduced
GATv2
module,
featuring
flexible
dynamic
attention
mechanism
capture
relationships
between
spots.
This
improves
identification
patterns
analysis.
Additionally,
incorporates
skip
connections
loss
information,
thereby
enhancing
prediction
capability
rare
types.
Experimental
results
show
outperforms
state-of-the-art
reconstructing
on
multiple
datasets.
Notably,
reveals
tumor
heterogeneity
human
pancreatic
ductal
adenocarcinoma
samples
and
delineates
complex
tissue
structures,
such
as
laminar
organization
mouse
cerebral
cortex
cerebellum.
These
findings
highlight
ability
provide
reliable
low-dimensional
embeddings
downstream
analyses,
offering
new
opportunities
deciphering
structures.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 30, 2024
Dystroglycan
is
a
cell
adhesion
molecule
that
localizes
to
synapses
throughout
the
nervous
system.
While
required
maintain
inhibitory
from
cerebellar
molecular
layer
interneurons
(MLIs)
onto
Purkinje
cells
(PCs)
whether
initial
synaptogenesis
during
development
dependent
on
has
not
been
examined.
We
show
conditional
deletion
of