Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

---

Inhibition of HCN channels decreases motivation for alcohol and deprivation-induced drinking in alcohol preferring rats

Neuropharmacology, Год журнала: 2025, Номер unknown, С. 110371 - 110371

Опубликована: Фев. 1, 2025

Язык: Английский

---

Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system

Cell Reports, Год журнала: 2025, Номер 44(4), С. 115482 - 115482

Опубликована: Март 29, 2025

Язык: Английский

---

An inhibitory GLP-1 circuit in the lateral septum modulates reward processing and alcohol intake in rodents

EBioMedicine, Год журнала: 2025, Номер 115, С. 105684 - 105684

Опубликована: Апрель 17, 2025

Язык: Английский

---

A Prefrontal Cortex-Nucleus Accumbens Circuit Attenuates Cocaine-conditioned Place Preference Memories

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

The infralimbic (IL) subregion of the prefrontal cortex (PFC), via its descending projection to nucleus accumbens (NAc), inhibits cue-induced drug seeking and reinstatement, but underlying mechanisms are not fully understood. Here we show that activity IL layer 5 pyramidal neurons projecting NAc shell (IL-NAcSh neurons) suppresses cocaine-associated memories. Following repeated cocaine exposures in a conditioned place preference paradigm, IL-NAcSh anatomically traced by fluorescent Retrobeads undergo prolonged decrease membrane excitability, lasting for at least 15 days after withdrawal. This persistent neuron hypoexcitability is accompanied an increase rheobase, afterhyperpolarization potential, input resistance. induced neuroadapation intrinsic excitability observed prelimibic core (PL-NAcCo neurons), separate circuit thought promote cue-triggered seeking. Chemogenetic restoration extinguishes both acquisition retention Our results provide direct support notion serves extinct associated memories restoring impaired has potential mitigate drug-cue association

Язык: Английский

---

A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

SUMMARY Adaptive regulation of feeding depends on linkage internal states and food outcomes with contextual cues. Human brain imaging has identified dysregulation a hippocampal-lateral hypothalamic area (LHA) network in binge eating, but mechanistic instantiation underlying cell-types circuitry is lacking. Here, we identify an evolutionary conserved discrete Prodynorphin ( Pdyn )-expressing subpopulation Somatostatin Sst inhibitory neurons the dorsolateral septum (DLS) that receives primarily dorsal, not ventral, hippocampal inputs. DLS( ) inhibit LHA GABAergic confer context- state-dependent calibration feeding. Viral deletion DLS mimicked effects seen optogenetic silencing INs, suggesting potential role for DYNORPHIN-KAPPA OPIOID RECEPTOR signaling food-seeking. Together, our findings illustrate how dorsal hippocampus evolved to recruit ancient circuit module through link information consumption. HIGHLIGHTS receive dense input from ventral Silencing hippocampus-DLS( )-LHA nodes abolishes context-conditioned necessary

Язык: Английский

---

Adaptive circuits for action and value information in rodent operant learning

Neuroscience Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

---

Adiponectin receptor 1-mediated basolateral amygdala-prelimbic cortex circuit regulates methamphetamine-associated memory

Cell Reports, Год журнала: 2024, Номер 43(12), С. 115074 - 115074

Опубликована: Дек. 1, 2024

The association between drug-induced rewards and environmental cues represents a promising strategy to address addiction. However, the neural networks molecular mechanisms orchestrating methamphetamine (MA)-associated memories remain incompletely characterized. In this study, we demonstrated that AdipoRon (AR), specific adiponectin receptor (AdipoR) agonist, inhibits formation of MA-induced conditioned place preference (CPP) in MA-conditioned mice, accompanied by suppression basolateral amygdala (BLA) CaMKIIα neuron activity. Furthermore, identified an excitatory circuit from BLA prelimbic cortex (PrL) integration with cues. We also determined phosphorylated AMPK (p-AMPK)/Cav1.3 signaling pathway mediates modulatory effects AdipoR1 PrL-projecting neurons on MA reward memories, process influenced physical exercise. These findings highlight critical function

Язык: Английский

---

A bone-derived protein primes rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 13, 2024

SUMMARY Rapid escape against visual threats is critical for survival. Whether it requires a permissive mechanism unknown. Here, we show that osteocalcin (OCN), protein produced by bone and persisted in the brain, primes rapid response increasing excitability of VTA GABAergic neuron subpopulation via OCN-GPR37-cAMP-THIK-1 (K 2P 13.1) pathway. Knock-out OCN or its receptor GPR37, conditional knock-out GPR37 glutamatergic neurons caused delayed escape. Reconstituting OCN-GPR37 signaling specifically was sufficient to restore normal response. Single-cell transcriptomics combined with electrophysiology showed decreases potassium currents GPR37-induced cAMP reduction subsequent THIK-1 suppression. This elevation can be recapitulated HM4Di, an inhibitory chemogenetic GPCR commonly used suppress neuronal activity. Our study demonstrated behavior bone-derived tunes central nervous system neurons. Graph Abstract In brief The bone-brain axis regulates behavior. Osteocalcin small secreted bone, plays role achieved through expressed increases decreasing K+ current channel Highlights are required Osteocalcin-GPR37 suppressing reduction. Activation HM4Di enhances

Язык: Английский

---

The lateral septum returns to the center stage of brain reward

Neuron, Год журнала: 2024, Номер 112(16), С. 2666 - 2668

Опубликована: Авг. 1, 2024

Язык: Английский

---