Neural Oscillations in the Somatosensory and Motor Cortex Distinguish Dexmedetomidine‐Induced Anesthesia and Sleep in Rats
CNS Neuroscience & Therapeutics,
Год журнала:
2025,
Номер
31(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Background
Anesthesia
is
featured
by
behavioral
and
physiological
characteristics
such
as
decreased
sensory
motor
function,
loss
of
consciousness,
etc.
Some
anesthetics
dexmedetomidine
(DEX),
induce
electroencephalogram
signatures
close
to
non‐rapid
eye
movement
sleep.
Studies
have
shown
that
sleep
primarily
driven
the
activation
subcortical
sleep‐promoting
neural
pathways.
Aims
However,
neuronal
level
electrophysiology
features
anesthesia
how
they
differ
from
still
not
fully
understood.
Materials
Methods
In
present
study,
we
recorded
activity
simultaneously
somatosensory
cortex
(S1)
(M1)
during
awake,
sleep,
DEX‐induced
in
rats.
Results
The
results
show
DEX
increased
local
field
potential
(LFP)
power
across
a
relatively
wide
band
(1–25
Hz)
both
S1
M1.
coherence
between
LFP
M1
significantly
delta
alpha
bands.
Power
spectrum
analysis
revealed
high
bands,
but
low
theta
beta
Overall,
firing
rate
individual
neurons
after
DEX.
Correlation
indicate
more
were
correlated,
either
positively
or
negatively,
with
LFPs
compared
Discussion
Although
these
showed
enhancement
cortical
different
patterns
spike‐field
correlation
suggest
two
states
may
be
regulated
mechanisms.
Conclusion
Distinguishing
oscillations
could
lead
personalized,
safer,
effective
approaches
managing
consciousness
medical
settings,
for
broad
applications
neuroscience
clinical
practice.
Язык: Английский
Propofol alleviates traumatic brain injury through regulating Th17/Treg balance by activation of the AMPK/SIRT1 pathway
Toxicology Mechanisms and Methods,
Год журнала:
2025,
Номер
unknown, С. 1 - 11
Опубликована: Апрель 2, 2025
Traumatic
brain
injury
(TBI),
a
prevalent
neurological
disorder
in
clinical
practice,
is
primarily
induced
by
external
trauma.
Propofol
has
been
reported
to
alleviate
the
symptoms
associated
with
TBI.
In
this
study,
TBI
model
was
established
mice
using
controlled
cortical
impact
(CCI)
method.
After
treatment
propofol
and
BML-275,
neuronal
damage
assessed
through
modified
Neurological
Severity
Score
(mNSS),
Hematoxylin
Eosin
(HE)
staining,
Nissl
staining.
To
investigate
role
of
AMPK/SIRT1
pathway
propofol-regulated
TBI,
AMPKα-silenced
vectors
overexpressed
SIRT1
were
transfected.
Western
blot
performed
evaluate
expression
proteins
involved
pyroptosis
markers.
The
regulatory
Th17/Treg
balance
examined
detecting
key
transcription
factors
RORγt
FOXP3
immunofluorescent
staining
RT-qPCR.
Enzyme-linked
immunosorbent
assay
(ELISA)
used
measure
IL-17
IL-10
concentrations.
Results
showed
that
significantly
reduced
model,
an
effect
reversed
BML-275.
Moreover,
mitigated
downregulating
Caspase-1
GSDMD-N
post-TBI.
inhibited
Th17
differentiation
while
promoting
Treg
modulating
RORγt/FOXP3
IL-17/IL-10
levels.
Silencing
AMPKα
markedly
diminished
propofol's
effects
on
differentiation,
these
being
upon
overexpression.
suppressed
regulation
via
activation
pathway.
These
findings
suggest
exerts
protective
against
following
potentially
modulation
signaling
Язык: Английский
Stability from subspace rotations and traveling waves
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 19, 2024
Abstract
Cortical
activity
shows
the
ability
to
recover
from
distractions.
We
analyzed
neural
prefrontal
cortex
(PFC)
of
monkeys
performing
working
memory
tasks
with
mid-memory-delay
distractions
(a
cued
gaze
shift
or
an
irrelevant
visual
input).
After
distraction
there
were
state-space
rotational
dynamics
that
returned
spiking
population
patterns
similar
those
pre-disruption.
In
fact,
rotations
fuller
when
task
was
performed
correctly
versus
errors
made.
found
a
correspondence
between
and
traveling
waves
across
surface
PFC.
This
suggests
role
for
emergent
like
in
recovery
Язык: Английский
Neural waves and computation in a neural net model II: Data-like structures and the dynamics of episodic memory
Journal of Computational Neuroscience,
Год журнала:
2024,
Номер
52(3), С. 223 - 243
Опубликована: Июль 31, 2024
Язык: Английский
Brain Scale Free Criticality and Renormalization Extended for Unification and Consciousness Theories
Опубликована: Июль 21, 2024
Recent
articles
summarizing
research
noting
the
proclivity
of
renormalization
techniques
to
solve
brain
self-organized
criticality
and
deep
learning
could
intimate
that
challenges
with
unification
Quantum
Mechanics
Relativity,
finding
a
formal
solution
for
quantum
decoherence
or
even
consciousness,
be
chimeras
if
human
observed
nature
reality
itselfare
renormalizations
an
infinite
fractal
space-time
is
intractable
current
techniques.
Язык: Английский
IL‐12p70 Induces Neuroprotection via the PI3K‐AKT‐BCL2 Axis to Mediate the Therapeutic Effect of Electroacupuncture on Postoperative Cognitive Dysfunction
Advanced Biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Abstract
Postoperative
cognitive
dysfunction
(POCD),
a
postsurgical
decline
in
function,
primarily
affects
older
adults
and
worsens
their
prognosis.
Although
elevated
interleukin‐12p70
(IL‐12p70)
is
closely
correlated
with
slower
adults,
its
role
POCD
remains
unclear.
Here,
IL‐12p70
identified
as
significant
mediator
of
therapeutic
effect
electroacupuncture
(EA)
on
POCD.
EA
at
acupoints
ST36,
GV20,
GV24
significantly
enhanced
behaviors
mice.
IL‐12p70,
downregulated
mice
but
rescued
by
treatment,
the
cytokine
associated
EA's
effect.
Clinically,
adults’
serum
post‐surgery.
Furthermore,
exerts
potent
neuroprotective
both
neuronal
cell
lines
primary
hippocampal
neurons.
The
PI3K‐AKT‐BCL2
axis
enriched
silico
analysis
validated
signaling
mechanism
underlying
IL‐12p70‐induced
neuroprotection.
In
vivo,
beneficial
effects
treatment
activation
are
reproduced
administration
attenuated
knockdown.
findings
reveal
novel
POCD,
demonstrating
that
activating
newly‐discovered
function
highlight
potential
treating
disorders.
Язык: Английский
Predictive routing emerges from self-supervised stochastic neural plasticity
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
Abstract
Neurophysiology
studies
propose
that
predictive
coding
is
implemented
via
alpha/beta
(8-30
Hz)
rhythms
prepare
specific
pathways
to
process
predicted
inputs.
This
leads
a
state
of
relative
inhibition,
reducing
feedforward
gamma
(40-90
and
spiking
predictable
We
refer
this
model
as
routing.
It
currently
unclear
which
circuit
mechanisms
implement
push-pull
interaction
between
rhythms.
To
explore
how
routing
implemented,
we
developed
self-supervised
learning
algorithm
call
generalized
Stochastic
Delta
Rule
(gSDR).
was
necessary
develop
rule
because
manual
tuning
parameters
(frequently
used
in
computational
modeling)
inefficient
search
through
non-linear
parameter
space
defines
neuronal
emerge
interact.
gSDR
train
biophysical
neural
circuits
validated
the
on
simple
tasks,
e.g.,
membrane
potentials
firing
rates.
next
applied
observed
neurophysiology.
asked
reproduce
shift
from
baseline
oscillatory
dynamics
(∼<20Hz)
stimulus
induced
(∼40-90Hz)
recorded
macaque
monkey
visual
cortex.
gamma-band
oscillation
during
stimulation
emerged
by
self-modulation
synaptic
weights
gSDR.
further
showed
gamma-beta
interactions
implied
could
stochastic
modulation
both
local
inhibitory
circuitry
well
top-down
modulatory
inputs
network.
summarize,
based
series
objectives.
succeeded
implementing
these
revealed
neuron
underlying
are
processing
tasks
systems
cognitive
neuroscience.
Significant
Statement
study
contributes
advancement
for
modeling
behavior
complex
specifically,
models
framework.
Since
an
evolutionary
does
not
rely
model-based
assumptions,
it
improve
autonomous
approaches
neuroscience
network
research.
Язык: Английский