Early-life stress sensitizes response to future stress: Evidence and mechanisms
Neurobiology of Stress,
Год журнала:
2025,
Номер
35, С. 100716 - 100716
Опубликована: Март 1, 2025
Early-life
stress
sensitizes
individuals
to
additional
stressors
and
increases
lifetime
risk
for
mood
anxiety
disorders.
Research
in
both
human
populations
rodent
models
of
early-life
have
sought
determine
how
different
types
contribute
vulnerability,
whether
there
are
developmental
sensitive
periods
such
effects.
Although
differences
the
type
timing
paradigms
led
specific
behavioral
outcomes,
this
complexity
is
present
among
humans
as
well.
Robust
research
now
shows
sensitivity
future
at
behavioral,
neural
circuit,
molecular
levels.
These
recent
discoveries
laying
foundation
translation
more
effective
interventions
relevant
those
who
experienced
childhood
trauma.
Язык: Английский
The evolving neurobiology of early-life stress
Neuron,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Chromatin regulation of neuronal activity-dependent gene programs in circuit formation and plasticity
Current Opinion in Neurobiology,
Год журнала:
2025,
Номер
92, С. 103024 - 103024
Опубликована: Апрель 21, 2025
Neuronal
activity-dependent
transcription
is
crucial
for
the
development
and
plasticity
of
neuronal
circuits.
At
chromatin
level,
induction
activity-regulated
genes
orchestrated
through
various
mechanisms,
including
deposition
histone
modifications
at
regulatory
elements,
binding
transcriptional
activators
repressors,
remodeling,
control
3D
genome
architecture.
Here,
we
review
our
current
understanding
how
mechanisms
regulate
temporally
distinct
waves
following
stimulation
allow
neurons
to
mount
cell
type-specific
stimulus-specific
responses.
We
also
highlight
a
specific
epigenetic
mechanism
in
developing
that
maintains
immediate
early
(IEGs)
an
inactive
though
poised
state,
while
simultaneously
preparing
them
rapid
activation
response
sensory
stimulation.
discuss
regulation
play
role
controlling
gene
expression,
enabling
implementation
precise
expression
programs
during
different
stages
neural
circuit
plasticity.
Язык: Английский
Blueprints for healing: central nervous system regeneration in zebrafish and neonatal mice
BMC Biology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 30, 2025
In
adult
mammals,
including
humans,
neurons,
and
axons
in
the
brain
spinal
cord
are
inherently
incapable
of
regenerating
after
injury.
Studies
animals
with
innate
capacity
for
regeneration
providing
valuable
insights
into
mechanisms
driving
tissue
healing.
The
aim
this
review
is
to
summarize
recent
data
on
zebrafish
neonatal
mice.
We
infer
that
elucidating
these
understanding
how
why
they
lost
mammals
will
contribute
development
strategies
promote
central
nervous
system
regeneration.
Язык: Английский
Histone variant H2BE controls activity-dependent gene expression and homeostatic scaling
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 2, 2024
SUMMARY
A
cell’s
ability
to
respond
and
adapt
environmental
stimuli
relies
in
part
on
transcriptional
programs
controlled
by
histone
proteins.
Histones
affect
transcription
through
numerous
mechanisms
including
replacement
with
variant
forms
that
carry
out
specific
functions.
We
recently
identified
the
first
widely
expressed
H2B
variant,
H2BE
found
it
promotes
is
critical
for
neuronal
function
long-term
memory.
However,
how
regulated
extracellular
whether
controls
activity-dependent
cellular
plasticity
remain
unknown.
used
CUT&Tag
RNA-sequencing
of
primary
neurons,
single-nucleus
sequencing
cortical
tissue,
multielectrode
array
recordings
interrogate
expression
response
role
gene
plasticity.
find
unlike
Further,
we
show
neurons
lacking
are
unable
mount
proper
responses
both
cultured
animal
models.
Lastly,
demonstrate
knockout
fail
undergo
electrophysiological
changes
associated
homeostatic
after
stimulation.
In
summary,
these
data
inversely
correlated
activity
necessary
responses,
revealing
instance
a
involved
neurons.
Язык: Английский