Current Opinion in Neurobiology, Год журнала: 2025, Номер 92, С. 103025 - 103025
Опубликована: Апрель 22, 2025
Язык: Английский
Ageing & Longevity, Год журнала: 2025, Номер 1.2025, С. 28 - 34
Опубликована: Янв. 28, 2025
Ageing is a key factor in the development of cognitive decline and neurodegeneration, including Alzheimer’s disease (AD), most common form dementia diagnosed. In 2023 US Federal Drug Administration (FDA) approved new drug (Lecanemab, Leqembi) to treat AD that very moderately slows down early-stage (van Dyck et al., 2023). Donanemab (Kisunla, Eli Lilley), acting similarly lecanemab, was by FDA 2024 US, but not yet European Medicines Agency (EMA) EU. The mechanism action both these monoclonal antibodies similar aducanumab (Aduhelm), conditionally for 2021 (but subsequently discontinued producer), on reducing β-amyloid deposits (Sevigny 2016; van However, trials all revealed significant adverse events (brain swelling or brain bleeding); hence treatment neurodegeneration general remains an important unmet medical need, affecting millions people worldwide. Here I discuss role noradrenergic system innervating spinal cord, consisting nucleus locus coeruleus (LC), which appears be vulnerable structure central nervous (CNS) ageing-related factors, leading early LC demise impairments. Therefore, propose understanding noradrenaline cells, particular astrocytes, homeostasis-providing exhibit high density adrenergic receptors, future strategy develop drugs mitigate decline. Keywords: ageing; noradrenaline; adrenoceptors; coeruleus; neuroglia, astrocytes
Язык: Английский
Процитировано
1
The Transmitter, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(3), С. 255 - 255
Опубликована: Фев. 22, 2025
Locus Coeruleus (LC) is a brain nucleus that involved in variety of key functions (ranging from attention modulation to sleep-wake cycle regulation, memory encoding); its proper function necessary both during development and for integrity maintenance, at the microscale macroscale level. Due their specific intrinsic extrinsic features, LC cells are considered particularly susceptible damage concerning insults. This explains involvement degenerative diseases not only adults (in context neurodegenerative disease, mainly), but also children relation early hypoxic Down's Syndrome, among others). In this narrative review, we dissect potential mechanisms through which affected different diseases, with special emphasis on high rate activity it subjected oxidative stress associated it. Further research aimed deepening our understanding these needed enable strategies future could slow down degeneration subjects predisposed disorders.
Язык: Английский
Процитировано
0
Brain Communications, Год журнала: 2025, Номер 7(2)
Опубликована: Янв. 1, 2025
Our Associate Editor, Laurent Sheybani, discusses some very old and recent findings on sleep physiology function, hoping to raise further interest publications in the field.
Язык: Английский
Процитировано
0
Current Opinion in Neurobiology, Год журнала: 2025, Номер 92, С. 103025 - 103025
Опубликована: Апрель 22, 2025
Язык: Английский
Процитировано
0