
Frontiers in Molecular Neuroscience, Год журнала: 2025, Номер 18
Опубликована: Март 12, 2025
As mobile phones and communication base stations become more widespread, concerns have arisen regarding the potential risks of environmental exposure to multi-frequency electromagnetic radiation (EMR) its effects on mental health. To address these concerns, our study established a dual-frequency EMR mouse model at 0.8/2.65 GHz explore molecular mechanisms intervention targets. Our results revealed that this significantly induced anxiety-like behavior in mice. Molecular experiments further showed significant decrease cannabinoid receptor type 1 (CB1R) levels medial prefrontal cortex (mPFC) mice, along with notable reduction endogenous cannabinoids 2-arachidonoylglycerol anandamide. This led downregulation entire endocannabinoid system (ECS). Additional confirmation was obtained by overexpressing knocking down CB1R mPFC. We found increasing mPFC could effectively reduce behavior, while decreasing exacerbated it. Furthermore, we change ECS basolateral amygdala (BLA). Notably, female mice exhibited similar behavioral phenotypes response EMR. In summary, demonstrates anxiety is closely linked function BLA, expression plays role modulating emotional
Язык: Английский