Unraveling the interplay between sleep, redox metabolism, and aging: implications for brain health and longevity

Frontiers in Aging, Год журнала: 2025, Номер 6

Опубликована: Май 21, 2025

The relationship between sleep and metabolism has emerged as a critical factor in aging age-related diseases, including Alzheimer's disease dementia. Mitochondrial oxidative phosphorylation, essential for neuronal energy production, also generates reactive oxygen species (ROS), which increase with age contribute to stress. Sleep plays vital role modulating redox balance, facilitating the clearance of free radicals, supporting mitochondrial function. Disruptions are closely linked imbalances, emerging evidence suggests that pharmacological interventions, such dual orexin receptor antagonists antioxidant-based therapies, may help restore homeostasis. Furthermore, antioxidant-rich diets supplements have shown promise improving both quality metabolic health populations. Neurons, their high demands, particularly vulnerable damage, making regulation crucial maintaining brain integrity. This review explores bidirectional through five key areas: (1) sleep's radical regulation, (2) ROS mediators disturbances, (3) feedback loops impaired metabolism, (4) sleep, redox, peripheral systems, (5) therapeutic strategies balance improve outcomes. Understanding these mechanisms provide new targets interventions aimed at mitigating age-associated diseases.

Язык: Английский

Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy

Nature Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Язык: Английский