From sensation to regulation: the diverse functions of peripheral sensory nervous system DOI Creative Commons

Yixiao Mei,

Binglin Zhou,

Da Zhong

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Май 16, 2025

The peripheral sensory nervous system (PNS) has been widely recognized for its role in the collection, processing, and transmission of information, including thermal, mechanical, chemical, proprioceptive stimuli. In recent years, there a growing scholarly interest PNS attributable to multiple physiological pathophysiological non-sensory roles organs it innervates. exerts regulatory functions within innervates through direct interactions with local cells or microbe-nerve-cell that differ from traditional feedback modes used by hormonal brain-sympathetic/parasympathetic systems. release neuropeptide calcitonin gene related peptide (CGRP) nerves, action on CGRP receptors cells, constitutes primary molecular axis regulation organ maintaining tissue homeostasis, facilitating pathological processes, modulating innate adaptive immunity. This review highlights various tissues organs, focusing phenotypes, mechanisms their significance, while also exploring future research directions, methodologies potential preclinical studies aimed at targeting these pathways development novel therapies.

Язык: Английский

Ferroptosis and Iron Homeostasis: Molecular Mechanisms and Neurodegenerative Disease Implications DOI Creative Commons
Nurzhan Abdukarimov, Kamilya Kokabi, Jeannette Kunz

и другие.

Antioxidants, Год журнала: 2025, Номер 14(5), С. 527 - 527

Опубликована: Апрель 28, 2025

Iron dysregulation has emerged as a pivotal factor in neurodegenerative pathologies, especially through its capacity to promote ferroptosis, unique form of regulated cell death driven by iron-catalyzed lipid peroxidation. This review synthesizes current evidence on the molecular underpinnings focusing how disruptions iron homeostasis interact with key antioxidant defenses, such system Xc--glutathione-GPX4 axis, tip neurons toward lethal oxidative damage. Building these mechanistic foundations, we explore ferroptosis intersects hallmark pathologies Alzheimer's disease (AD) and Parkinson's (PD) examine accumulation vulnerable brain regions may fuel disease-specific protein aggregation neurodegeneration. We further surveyed distinct components highlighting role peroxidation enzymes, mitochondrial dysfunction, recently discovered parallel pathways that either exacerbate or mitigate neuronal death. Finally, discuss insights open new avenues for neuroprotective strategies, including chelation inhibitors. By questions, this seeks clarify state knowledge proposes directions harness modulation intervention.

Язык: Английский

Процитировано

0
A gut-wrenching tale of neuronal distress DOI

Murillo Duarte-Silva,

Meenakshi Rao

Neuron, Год журнала: 2025, Номер 113(9), С. 1291 - 1293

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
From sensation to regulation: the diverse functions of peripheral sensory nervous system DOI Creative Commons

Yixiao Mei,

Binglin Zhou,

Da Zhong

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Май 16, 2025

The peripheral sensory nervous system (PNS) has been widely recognized for its role in the collection, processing, and transmission of information, including thermal, mechanical, chemical, proprioceptive stimuli. In recent years, there a growing scholarly interest PNS attributable to multiple physiological pathophysiological non-sensory roles organs it innervates. exerts regulatory functions within innervates through direct interactions with local cells or microbe-nerve-cell that differ from traditional feedback modes used by hormonal brain-sympathetic/parasympathetic systems. release neuropeptide calcitonin gene related peptide (CGRP) nerves, action on CGRP receptors cells, constitutes primary molecular axis regulation organ maintaining tissue homeostasis, facilitating pathological processes, modulating innate adaptive immunity. This review highlights various tissues organs, focusing phenotypes, mechanisms their significance, while also exploring future research directions, methodologies potential preclinical studies aimed at targeting these pathways development novel therapies.

Язык: Английский

Процитировано

0