The Microbiota-Gut-Brain Axis

Physiological Reviews, Год журнала: 2019, Номер 99(4), С. 1877 - 2013

Опубликована: Авг. 28, 2019

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, past 15 yr have seen emergence microbiota (the trillions microorganisms within and on our bodies) as one key regulators function led to appreciation a distinct microbiota-gut-brain axis. This is gaining ever more traction fields investigating biological physiological basis psychiatric, neurodevelopmental, age-related, neurodegenerative disorders. brain communicate with each other via various routes including immune system, tryptophan metabolism, vagus nerve enteric nervous involving microbial metabolites such short-chain fatty acids, branched chain amino peptidoglycans. Many factors can influence composition early life, infection, mode birth delivery, use antibiotic medications, nature nutritional provision, environmental stressors, host genetics. At extreme diversity diminishes aging. Stress, particular, significantly impact at all stages life. Much recent work implicated gut many conditions autism, anxiety, obesity, schizophrenia, Parkinson’s disease, Alzheimer’s disease. Animal models paramount linking regulation fundamental neural processes, neurogenesis myelination, microbiome activation microglia. Moreover, translational human studies are ongoing will greatly enhance field. Future focus understanding mechanisms underlying attempt elucidate microbial-based intervention therapeutic strategies for neuropsychiatric

Язык: Английский

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Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Cell Host & Microbe, Год журнала: 2018, Номер 23(6), С. 716 - 724

Опубликована: Июнь 1, 2018

Язык: Английский

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Neurotransmitter modulation by the gut microbiota

Brain Research, Год журнала: 2018, Номер 1693, С. 128 - 133

Опубликована: Июнь 11, 2018

Язык: Английский

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Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Nature Reviews Drug Discovery, Год журнала: 2019, Номер 18(5), С. 379 - 401

Опубликована: Фев. 13, 2019

Язык: Английский

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Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice

Biological Psychiatry, Год журнала: 2017, Номер 82(7), С. 472 - 487

Опубликована: Фев. 24, 2017

Язык: Английский

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The Microbiota-Gut-Brain Axis: From Motility to Mood

Gastroenterology, Год журнала: 2021, Номер 160(5), С. 1486 - 1501

Опубликована: Янв. 22, 2021

Язык: Английский

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Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain

Advances in Nutrition, Год журнала: 2019, Номер 11(3), С. 709 - 723

Опубликована: Ноя. 8, 2019

Язык: Английский

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The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology

Frontiers in Immunology, Год журнала: 2020, Номер 11

Опубликована: Дек. 10, 2020

The human microbiota has a fundamental role in host physiology and pathology. Gut microbial alteration, also known as dysbiosis, is condition associated not only with gastrointestinal disorders but diseases affecting other distal organs. Recently it became evident that the intestinal bacteria can affect central nervous system (CNS) inflammation. tract are communicating through bidirectional network of signaling pathways called gut-brain axis, which consists multiple connections, including vagus nerve, immune system, bacterial metabolites products. During these dysregulated altered permeability blood-brain barrier (BBB) neuroinflammation. However, numerous mechanisms behind impact gut neuro-development -pathogenesis remain poorly understood. There several involved CNS homeostasis Among those, inflammasome pathway been linked to neuroinflammatory conditions such sclerosis, Alzheimer’s Parkinson’s diseases, anxiety depressive-like disorders. complex assembles upon cell activation due exposure microbes, danger signals, or stress lead production pro-inflammatory cytokines (interleukin-1β interleukin-18) pyroptosis. Evidences suggest there reciprocal influence brain. how this precisely working yet be discovered. Herein, we discuss status knowledge open questions field focusing on function products cells during healthy inflammatory conditions, neuropsychiatric In particular, focus innate mechanism certain microbes.

Язык: Английский

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Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry

Translational research, Год журнала: 2016, Номер 179, С. 223 - 244

Опубликована: Окт. 22, 2016

Язык: Английский

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The Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications

Clinical Gastroenterology and Hepatology, Год журнала: 2018, Номер 17(2), С. 322 - 332

Опубликована: Окт. 4, 2018

Язык: Английский

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