Research progress on the protection and mechanism of active peptides in Alzheimer's disease and Parkinson's disease

Neuropeptides, Год журнала: 2024, Номер 107, С. 102457 - 102457

Опубликована: Июль 25, 2024

Язык: Английский

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Adenosine A2A signaling in mood disorders: how far have we come?

IBRO Neuroscience Reports, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Control of Dopamine Signal in High-Order Receptor Complex on Striatal Astrocytes

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8610 - 8610

Опубликована: Авг. 7, 2024

The receptor-receptor interaction (RRI) of G protein-coupled receptors (GPCRs) leads to new functional entities that are conceptually distinct from the simple addition signals mediated by activation form heteromers. Focusing on astrocytes, there is evidence for existence inhibitory and facilitatory RRIs, including heteromers formed adenosine A2A dopamine D2 receptors, oxytocin receptor (OTR), D2-OTR possible involvement these in mosaicism has never been investigated striatal astrocytes. By biophysical approaches, we focused our attention an A2A-D2-OTR high-order complex its role modulating cytosolic calcium levels endogenous glutamate release, when astrocyte processes were stimulated with 4-aminopyridine. Functional data indicate a permissive OTR signaling regulation glutamatergic transmission, control both D2-mediated OTR-facilitating effect D2. Imaging biochemical bioinformatic confirmed ternary structure membrane. In conclusion, appears be hotspot release astrocytic may contribute integration different neurotransmitter-mediated striatum heterotrimers. Considering selectivity allosteric interventions GPCRs organized as mosaics, heterotrimers offer selective pharmacological targets neuropsychiatric disorders neurodegenerative diseases.

Язык: Английский

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Possible roles of heteroreceptor complexes in excitotoxic processes

Exploration of Neuroprotective Therapy, Год журнала: 2024, Номер 4(5), С. 366 - 391

Опубликована: Сен. 24, 2024

Excitotoxicity represents a neuropathological process, describing the toxic actions of excitatory neurotransmitters, where excessive or prolonged activation glutamate receptors triggers cascade events leading to neuronal injury death. Under conditions reduced energy availability and increased oxidative stress neurons become particularly vulnerable excitotoxicity large body available evidence indicates that central mechanism in pathogenesis acute degenerative diseases nervous system. Astrocytes represent key elements regulation homeostasis by their opposing functions uptake release, microglial cells play an important role response damage. Depending on phenotype they assume when activated, can trigger immune defense neuroprotective processes. To perform both glial cell populations monitor extracellular space through panel receptors. Furthermore, variety signaling pathways also contribute modulation glutamatergic transmission, acting specific expressed neurons, astrocytes, microglia. In last decades, has been provided almost all families establish structural receptor-receptor interactions, formation heteroreceptor complexes at membrane cells. The cooperativity emerges ligands monomers forming these assemblies provides decoding apparatus with flexible dynamics terms recognition signal transduction allows integration incoming signals already level. Available data possible modulatory roles played excitotoxic processes will be here reviewed discussed. From pharmacological standpoint, findings may offer possibilities explore novel therapeutic strategies targeting receptor address disorders system associated dysregulation signaling.

Язык: Английский

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The Role of Dopamine Receptor Dimer Complexes in the Pathogenesis of Depression

Journal of Evolutionary Biochemistry and Physiology, Год журнала: 2024, Номер 60(5), С. 1960 - 1974

Опубликована: Сен. 1, 2024

Язык: Английский

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The role of dopamine receptor dimer complexes in the pathogenesis of depression

Российский физиологический журнал им  И  М  Сеченова, Год журнала: 2024, Номер 110(10), С. 1541 - 1558

Опубликована: Дек. 29, 2024

This abstract discusses the oligomerization of G protein-coupled receptors (GPCRs), which significantly expands functional capabilities cells in living organisms by modulating intracellular signaling pathways. provides a variety physiological effects both normal and pathological states. The structure localization brain one most studied heterodimers, D1-D2 receptor complex, its cascades, correlate with development depressive disorders, are examined. Sexual differences functioning this heterodimer analyzed, issue selectivity bivalent synthetic ligands activating specific pathways is discussed, highlighting their potential as therapeutic targets for targeted treatment disorders. concluding part addresses diversity dopamine heterodimers other members GPCR family role pathophysiology depression.

Язык: Английский

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Progress in metamodulation and receptor-receptor interaction: From physiology to pathology and therapy

Neuropharmacology, Год журнала: 2023, Номер 237, С. 109639 - 109639

Опубликована: Июнь 19, 2023

Язык: Английский

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