Unraveling the cGAS/STING signaling mechanism: impact on glycerolipid metabolism and diseases DOI Creative Commons
Jie Su,

Fuyu Cheng,

Wei Yuan

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Ноя. 28, 2024

The cyclic GMP-AMP synthase (cGAS) and its downstream effector, the stimulator of interferon genes (STING), are crucial components innate immune response, traditionally recognized for their role in detecting cytosolic DNA from pathogens damaged host cells. However, recent research indicates that cGAS-STING pathway also significantly impacts metabolic processes, particularly glycerolipid metabolism. Glycerolipids essential energy storage cellular membrane integrity, dysregulation is linked to disorders such as obesity, insulin resistance, non-alcoholic fatty liver disease (NAFLD). Both cGAS STING expressed various tissues, suggesting a potential lipid homeostasis. Chronic activation may promote inflammatory states exacerbate resistance accumulation, forming feedback loop dysfunction. This review explores emerging relationship between cGAS/STING signaling metabolism, discussing mechanisms through which this influences regulation therapeutic interventions. By integrating insights immunology we aim provide comprehensive understanding how axis serve novel target addressing enhancing health outcomes.

Язык: Английский

Impact of fatty acids on glutamate-related gene expression in the hippocampus: Focus on lauric acid DOI

Laura Romero-Muñoz,

Ana Belén Sanz-Martos, Nuria Del Olmo

и другие.

Neuroscience Letters, Год журнала: 2025, Номер 850, С. 138152 - 138152

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Unraveling the cGAS/STING signaling mechanism: impact on glycerolipid metabolism and diseases DOI Creative Commons
Jie Su,

Fuyu Cheng,

Wei Yuan

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Ноя. 28, 2024

The cyclic GMP-AMP synthase (cGAS) and its downstream effector, the stimulator of interferon genes (STING), are crucial components innate immune response, traditionally recognized for their role in detecting cytosolic DNA from pathogens damaged host cells. However, recent research indicates that cGAS-STING pathway also significantly impacts metabolic processes, particularly glycerolipid metabolism. Glycerolipids essential energy storage cellular membrane integrity, dysregulation is linked to disorders such as obesity, insulin resistance, non-alcoholic fatty liver disease (NAFLD). Both cGAS STING expressed various tissues, suggesting a potential lipid homeostasis. Chronic activation may promote inflammatory states exacerbate resistance accumulation, forming feedback loop dysfunction. This review explores emerging relationship between cGAS/STING signaling metabolism, discussing mechanisms through which this influences regulation therapeutic interventions. By integrating insights immunology we aim provide comprehensive understanding how axis serve novel target addressing enhancing health outcomes.

Язык: Английский

Процитировано

0