Symmetry,
Год журнала:
2023,
Номер
15(7), С. 1320 - 1320
Опубликована: Июнь 28, 2023
Previous
studies
demonstrated
an
asymmetry
of
left
predominance
for
mean
values
soluble
leucine
aminopeptidase
(LeuAP)
activity
in
the
frontal
cortex
(FC)
and
hypothalamus
adult
male
rats,
fluorimetrically
analyzed
by
hydrolysis
Leu-β-naphthylamide
as
a
substrate.
No
asymmetries
were
observed
nine
other
(L)
right
(R)
regions
obtained
from
rostro-caudally
sectioned
coronal
slices.
Neither
had
inter-hemispheric
differences
lactate
dehydrogenase
(LDH),
simultaneously
same
brain
(L
R)
animals.
However,
level
intra-hemispheric
or
correlation
LeuAP
LDH
between
such
has
not
been
analyzed.
In
order
to
obtain
additional
suggestions
on
functional
heterogeneity
LDH,
present
investigation,
correlations
with
rest
studied
is
described:
(A)
(LFC)
regions;
(B)
(RFC)
(C)
all
(D)
regions.
All
positive.
The
analysis
showed
greater
RFC
than
LFC
Greater
when
comparing
conclusion,
greatest
(suggesting
variability)
was
hemisphere.
results
great
homogeneity
both
intra-
studies.
eNeuro,
Год журнала:
2025,
Номер
12(1), С. ENEURO.0511 - 24.2024
Опубликована: Янв. 1, 2025
Cuprizone
(CPZ)
is
a
widely
used
toxin
that
induces
demyelinating
diseases
in
animal
models,
producing
multiple
sclerosis
(MS)-like
pathology
rodents.
CPZ
one
of
the
few
toxins
triggers
demyelination
and
subsequent
remyelination
following
cessation
its
application.
This
study
examines
functional
consequences
CPZ-induced
recovery
neural
communication
within
anterior
cingulate
cortex
(ACC),
with
particular
focus
on
inter-hemispheric
connectivity
via
corpus
callosum.
By
employing
wide-field,
high-speed,
voltage-sensitive
dye
imaging,
we
were
able
to
provide
real-time
mapping
activity
ACC
CPZ-fed
mice.
Although
could
not
record
physiological
signals
from
callosum,
results
demonstrated
notable
impairment
connections
most
pronounced
loss
observed
specific
coronal
slice
among
series
slices
examined.
Notably,
latency
signal
propagation
remained
largely
unaltered
despite
loss,
indicating
affects
extent,
rather
than
temporal
dynamics,
communication.
It
noteworthy
while
appeared
recover
fully
after
CPZ,
histological
analysis
revealed
only
partial
myelination,
discrepancy
between
structural
recovery.
These
findings
enhance
our
understanding
how
ACC's
role
orchestrating
activity,
particularly
light
slice-specific
nature
interhemispheric
impairments.
offer
new
insights
into
MS
pathology,
regarding
callosum
potential
therapeutic
strategies.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Abstract
Sensorimotor
processing
in
the
human
brain
is
largely
lateralized,
with
corpus
callosum
integrating
these
processes
into
a
unified
experience.
Following
complete
callosotomy,
this
integration
breaks
down,
resulting
disconnection
syndromes.
We
asked
how
much
of
sufficient
to
support
functional
unity—the
absence
syndrome—by
comparing
three
callosotomy
patients
one
retaining
only
splenium.
Using
lateralized
tasks
across
visual,
tactile,
visuospatial,
and
language
domains,
we
predicted
domain-specific
deficits
splenium-only
patient
based
on
established
anatomical
models
callosal
topography.
Strikingly,
while
exhibited
syndromes,
splenium
demonstrated
unity
all
domains—as
if
his
entire
were
intact.
Our
findings
highlight
brain’s
remarkable
capacity
maintain
behavioral
through
minimal
preserved
pathways,
highlighting
structure-dependent
reorganizational
allows
preserve
unity.
Neuropsychologia,
Год журнала:
2023,
Номер
188, С. 108627 - 108627
Опубликована: Июнь 20, 2023
The
surgical
section
of
the
corpus
callosum
(callosotomy)
has
been
frequently
demonstrated
to
result
in
a
left-ear
extinction
dichotic
listening.
That
is,
callosotomy
patients
report
stimulus
below
chance
level,
resulting
substantially
enhanced
right-ear
advantage
(REA)
compared
with
controls.
A
small
number
previous
studies
also
suggest
that
can
overcome
when
instruction
encourages
attend
selectively
stimulus.
In
present
case
study,
we
re-examine
role
selective
attention
listening
two
complete
and
40
age-
sex-matched
We
used
standardised
Bergen
dichotic-listening
paradigm
which
uses
stop-consonant-vowel
syllables
as
material
includes
both
free-report
selective-attention
condition.
As
was
predicted,
showed
clear
extinction.
However,
contrasting
earlier
reports,
did
not
find
any
evidence
for
relief
from
this
by
attending
conclude
demonstrations
an
attention-improved
recall
may
be
attributed
use
suboptimal
paradigms
or
residual
callosal
connectivity,
rather
than
representing
genuine
effect
attention.
Frontiers in Human Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Май 15, 2024
Functional
connectivity
(FC)
is
defined
in
terms
of
temporal
correlations
between
physiological
signals,
which
mainly
depend
upon
structural
(axonal)
connectivity;
it
commonly
studied
using
functional
magnetic
resonance
imaging
(fMRI).
Interhemispheric
FC
appears
mostly
supported
by
the
corpus
callosum
(CC),
although
several
studies
investigating
this
aspect
have
not
provided
conclusive
evidence.
In
context,
patients
whom
CC
was
resected
for
therapeutic
reasons
(split-brain
patients)
provide
a
unique
opportunity
research
into
issue.
The
present
study
aimed
at
with
resting-state
fMRI
interhemispheric
six
epileptic
who
undergone
surgical
resection
CC.
Human Brain Mapping,
Год журнала:
2024,
Номер
45(9)
Опубликована: Июнь 15, 2024
Abstract
The
corpus
callosum
(CC)
is
a
large
white
matter
fiber
bundle
in
the
brain
and
involved
various
cognitive,
sensory,
motor
processes.
While
implicated
developmental
psychiatric
disorders,
much
yet
to
be
uncovered
about
normal
development
of
this
structure,
especially
young
children.
Additionally,
while
sexual
dimorphism
has
been
reported
prior
literature,
observations
have
not
necessarily
consistent.
In
study,
we
use
morphometric
measures
including
surface
tensor‐based
morphometry
(TBM)
investigate
local
changes
shape
CC
children
between
ages
12
60
months,
intervals
months.
We
also
analyze
sex
differences
each
these
age
groups.
observed
larger
significant
clusters
earlier
v
24
m
48
localized
anterior
region
body
CC.
Sex
were
most
pronounced
group.
This
study
adds
growing
literature
work
aiming
understand
developing
emphasizes
utility
TBM
as
useful
tool
for
analyzing
regional
neuroanatomical
morphometry.
Symmetry,
Год журнала:
2023,
Номер
15(12), С. 2188 - 2188
Опубликована: Дек. 12, 2023
The
present
study
was
designed
to
establish
the
contribution
of
corpus
callosum
(CC)
cortical
representation
unilateral
taste
stimuli
in
human
primary
gustatory
area
(GI).
Unilateral
stimulation
tongue
applied
eight
patients
with
partial
or
total
callosal
resection
by
placing
a
small
cotton
pad
soaked
salty
solution
on
either
side
tongue.
Functional
images
were
acquired
1.5
Tesla
machine.
Diffusion
tensor
imaging
and
tractography
also
performed.
evoked
bilateral
activation
GI
all
patients,
including
those
CC,
prevalence
ipsilateral
hemisphere
stimulated
side.
Bilateral
observed
somatic
sensory
cortex
(SI)
most
which
more
intense
contralateral
SI.
This
report
confirms
previous
functional
studies
carried
out
control
subjects
neuropsychological
findings
callosotomized
showing
that
pathways
from
are
bilaterally
distributed,
an
predominance.
It
has
been
shown
CC
does
play
role,
although
not
exclusive
one,
symmetrical
sensitivity
area,
at
least
for
afferents
one
The
surgical
section
of
the
corpus
callosum
(callosotomy)
has
been
frequently
demonstrated
to
result
in
a
left-ear
extinction
dichotic
listening.
That
is,
callosotomy
patients
report
stimulus
below
chance
level,
resulting
substantially
enhanced
right-ear
advantage
(REA)
compared
with
controls.
A
small
number
previous
studies
also
suggest
that
can
overcome
when
instruction
encourages
attend
selectively
stimulus.
In
present
case
study,
we
re-examine
role
selective
attention
listening
two
complete
and
40
age-
sex-matched
We
used
standardised
Bergen
dichotic-listening
paradigm
which
uses
stop-consonant-vowel
syllables
as
material
includes
both
free-report
selective-attention
condition.
As
was
predicted,
showed
clear
extinction.
However,
contrasting
earlier
reports,
did
not
find
any
evidence
for
relief
from
this
by
attending
conclude
demonstrations
an
attention-improved
recall
may
be
attributed
use
suboptimal
paradigms
or
residual
callosal
connectivity,
rather
than
representing
genuine
effect
attention.
