Shared gray matter alterations in subtypes of addiction: a voxel-wise meta-analysis

Psychopharmacology, Год журнала: 2021, Номер 238(9), С. 2365 - 2379

Опубликована: Июль 27, 2021

Язык: Английский

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Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

Nature reviews. Neuroscience, Год журнала: 2023, Номер 24(4), С. 233 - 251

Опубликована: Фев. 23, 2023

Язык: Английский

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Insulin-mediated synaptic plasticity in the CNS: Anatomical, functional and temporal contexts

Neuropharmacology, Год журнала: 2017, Номер 136, С. 182 - 191

Опубликована: Дек. 6, 2017

For decades the brain was erroneously considered an insulin insensitive organ. Although gaps in our knowledge base remain, conceptual frameworks are starting to emerge provide insight into mechanisms through which facilitates critical functions like metabolism, cognition, and motivated behaviors. These diverse physiological behavioral activities highlight region-specific of CNS; that is, there is anatomical context CNS. Similarly, also a temporal Indeed, receptor activity can be conceptualized as continuum promotes neuroplasticity from development adulthood where it integral part healthy function. Unfortunately, resistance likely contributes deficits obesity type 2 diabetes mellitus (T2DM). This by cognitive function its actions regions hippocampus, well ability modulate behaviors nucleus accumbens ventral tegmental area. Thus, goals this review these anatomical, temporal, functional contexts regions, identify potentially time points along transition enhancement impairment may take place. article Special Issue entitled 'Metabolic Impairment Risk Factors for Neurodegenerative Disorders.'

Язык: Английский

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Dopamine and addiction: what have we learned from 40 years of research

Journal of Neural Transmission, Год журнала: 2018, Номер 126(4), С. 481 - 516

Опубликована: Дек. 19, 2018

Язык: Английский

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Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network

Brain Structure and Function, Год журнала: 2016, Номер 222(2), С. 981 - 1006

Опубликована: Июль 7, 2016

Oxytocin (OT) and vasopressin (AVP) regulate various social behaviors via activation of the OT receptor (OTR) AVP V1a (V1aR) in brain. Social behavior often differs across development between sexes, yet our understanding age sex differences brain OTR V1aR binding remains incomplete. Here, we provide an extensive analysis density throughout juvenile adult male female rats, with a focus on regions within decision-making network. were higher juveniles than adults associated reward socio-spatial memory key network cortical regions. We discuss possible implications these shifts for age-specific regulation behavior. Furthermore, less numerous differences. The direction was region-specific but consistently females males V1aR. Finally, almost all already present occurred denser compared to juveniles. Possible sex-specific behavior, as well potential underlying mechanisms, are discussed. Overall, findings important framework testing age- roles

Язык: Английский

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Dopamine D1 or D2 receptor-expressing neurons in the central nervous system

Addiction Biology, Год журнала: 2017, Номер 23(2), С. 569 - 584

Опубликована: Апрель 24, 2017

Abstract Dopamine signals mainly through D1 receptors (D1Rs) and D2 (D2Rs); D1R‐expressing or D2R‐expressing neurons contribute to distinct reward addictive behaviors. Traditionally, transgenic mice expressing green fluorescent protein (GFP) under D1R D2R promoters are used for verification in electrophysiology studies, whereas Cre employed behavioral research. However, it is unknown whether the same neuronal populations targeted GFP mice. Additionally, while D1Rs D2Rs known be expressed different striatal neurons, their expression patterns outside striatum remain unclear. The present study addressed these two questions by using several mouse lines proteins (GFP tdTomato) control of promoters. We found a high degree overlap between GFP‐positive Cre‐positive hippocampus. we discovered that were highly segregated orbitofrontal cortex, prefrontal dorsal ventral hippocampus, amygdala: ~4–34 percent co‐expressed receptors. Importantly, slice electrophysiological studies demonstrated D1R‐positive D1R‐negative hippocampal functionally line generated crossing Drd1a ‐Cre with reporter Ai14 line. Lastly, chronic alcohol intake differentially altered D2R‐positive neuron excitability CA1. These data suggest target striatum, may exert roles addiction.

Язык: Английский

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A psychoengineering paradigm for the neurocognitive mechanisms of biofeedback and neurofeedback

Neuroscience & Biobehavioral Reviews, Год журнала: 2016, Номер 68, С. 891 - 910

Опубликована: Июнь 22, 2016

Язык: Английский

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Complex Motor Learning and Police Training: Applied, Cognitive, and Clinical Perspectives

Frontiers in Psychology, Год журнала: 2019, Номер 10

Опубликована: Авг. 7, 2019

The practices surrounding police training of complex motor skills, including the use force, varies greatly around world, and even over course an officer's career. As nature policing changes with society advancement science technology, so should that officers undertake at both central (i.e., academy basic recruit training) local individual agency or precinct) levels. following review is intended to bridge gap between scientific knowledge applied practice inform best for skills are unique critical law enforcement, lethal force. We begin by providing a understanding fundamental cognitive processes underlying learning, from novel skill acquisition behaviors situational awareness decision-making precede action. Motor memory perception then discussed within context occupationally-relevant stress, evidence-based promote officer performance physiological responses stress during high-stakes encounters. A lack research identifying neurophysiological mechanisms learning in inferred evidence various clinical populations suffering disorders systems, Alzheimer's Parkinson's disease stroke. conclude this practical, organizational, systemic challenges implementing policing, provide recommendations will effectiveness occupational safety end-users trainers officers).

Язык: Английский

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Sex Differences and the Role of Estradiol in Mesolimbic Reward Circuits and Vulnerability to Cocaine and Opiate Addiction

Frontiers in Behavioral Neuroscience, Год журнала: 2020, Номер 14

Опубликована: Май 20, 2020

Although both men and women become addicted to drugs of abuse, transition addiction faster, experience greater difficulties remaining abstinent, relapse more often than men. In humans rodents, these sex differences in progression are associated with hormonal cycles. Higher concentrations fluctuating levels ovarian hormones females modulate the mesolimbic reward system influence reward-directed behavior. For example, female E2 influences dopamine activity within such that drug-directed behaviors normally rewarding reinforcing enhanced when circulating high. Therefore, neuroendocrine interactions, part, explain motivated by drug reward. Here, we review physiology function order explore notion response specifically cocaine opiates, result molecular neuroadaptations differentially develop depending upon state animal. We propose hormones, estrogen/estradiol, sensitize a specific set target neurons thereby increasing responsivity under either or opiates exposure drug-associated cues. These adaptations may ultimately serve uniquely guide motivational underlie factors cause be vulnerable opiate

Язык: Английский

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The Role of Sensorimotor Difficulties in Autism Spectrum Conditions

Frontiers in Neurology, Год журнала: 2016, Номер 7

Опубликована: Авг. 10, 2016

In addition to difficulties in social communication, current diagnostic criteria for autism spectrum conditions (ASC) also incorporate sensorimotor difficulties; repetitive motor movements and atypical reactivity sensory input (APA, 2013). This paper explores whether are associated with the development maintenance of symptoms ASC. Firstly, studies have shown coordinating into planning executing movement effectively Secondly, associations between coordination core ASC symptoms, suggesting these areas each strongly influence communication skills. Thirdly, begun demonstrate that could account reduced attention early development, a cascading effect on later social, communicative emotional development. These results suggest not only contribute non-social such as narrow circumscribed interests, but behaviours eye contact speech gesture, interpreting others' behaviour responding appropriately. Further research is needed explore link ASC, their contribution

Язык: Английский

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