Luminescent Lanthanide Infinite Coordination Polymers for Ratiometric Sensing Applications

Molecules, Год журнала: 2025, Номер 30(2), С. 396 - 396

Опубликована: Янв. 18, 2025

Ratiometric lanthanide coordination polymers (Ln-CPs) are advanced materials that combine the unique optical properties of ions (e.g., Eu3+, Tb3+, Ce3+) with structural flexibility and tunability polymers. These widely used in biological chemical sensing, environmental monitoring, medical diagnostics due to their narrow-band emission, long fluorescence lifetimes, excellent resistance photobleaching. This review focuses on composition, sensing mechanisms, applications ratiometric Ln-CPs. The mechanism relies two distinct emission bands, which provides a self-calibrating, reliable, precise method for detection. relative intensity ratio between these bands varies concentration target analyte, enabling real-time monitoring minimizing interference. approach is particularly suitable detecting trace analytes use complex environments where factors like background noise, temperature fluctuations, light variations may affect results. Finally, we outline future research directions improving design synthesis Ln-CPs, such as incorporating long-lifetime reference luminescent molecules, exploring near-infrared systems, developing up-conversion or two-photon materials. Progress areas could significantly broaden scope Ln-CP applications, especially biosensing, other fields.

Язык: Английский

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Additive Blending Effects on PEDOT:PSS Composite Films for Wearable Organic Electrochemical Transistors

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(11), С. 13384 - 13398

Опубликована: Март 8, 2024

Organic electrochemical transistors (OECTs) employing conductive polymers (CPs) have gained remarkable prominence and undergone extensive advancements in wearable implantable bioelectronic applications recent years. Among the diverse arrays of CPs, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a common choice for active-layer channel p-type OECTs, showing remarkably high transconductance amplification signals biosensing applications. This investigation focuses on novel engineering PEDOT:PSS composite materials by seamlessly integrating several additives, namely, dimethyl sulfoxide (DMSO), (3-glycidyloxypropyl)trimethoxysilane (GOPS), nonionic fluorosurfactant (NIFS), to fine-tune their electrical conductivity, self-healing capability, stretchability. To elucidate intricate influences DMSO, GOPS, NIFS additives formation films, theoretical calculations were performed, encompassing solubility parameters surface energies constituent components NIFS, PEDOT, PSS, PSS-GOPS polymers. Furthermore, we conducted comprehensive array material analyses, which reveal intricacies phase separation phenomenon its interaction with materials' characteristics. Our research identified optimal composition characterized outstanding stretchable capabilities. has proven be highly effective constructing an form OECT-based biosensors fabricated onto polydimethylsiloxane substrates detecting dopamine. Overall, these findings represent significant progress application films bioelectronics pave way development state-of-the-art technologies.

Язык: Английский

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Biosensors for psychiatric biomarkers in mental health monitoring

Biosensors and Bioelectronics, Год журнала: 2024, Номер 256, С. 116242 - 116242

Опубликована: Март 29, 2024

Psychiatric disorders are associated with serve disturbances in cognition, emotional control, or behavior regulation, yet few routine clinical tools available for the real-time evaluation and early-stage diagnosis of mental health. Abnormal levels biomarkers might imply biological, neurological, developmental dysfunctions psychiatric patients. Exploring biosensors that can provide rapid, in-situ, monitoring is therefore vital prevention, diagnosis, treatment, prognosis disorders. Recently, high sensitivity, selectivity, reproducibility have been widely developed, which mainly based on electrochemical optical sensing technologies. This review presented morbidity, disability, mortality, followed by describing pathophysiology a biomarker-implying manner. The latest developed detecting representative (e.g., cortisol, dopamine, serotonin) were comprehensively summarized compared their technologies, applicable biological platforms, integrative readouts. These well-developed promising facilitating utility commercialization point-of-care diagnostics. It anticipated healthcare be gradually improved multiple perspectives, from innovations terms biometric elements, transducing principles, flexible readouts, to construction "Big-Data" networks used share intractable indicators cases.

Язык: Английский

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Dysfunction of synaptic endocytic trafficking in Parkinson’s disease

Neural Regeneration Research, Год журнала: 2024, Номер 19(12), С. 2649 - 2660

Опубликована: Март 1, 2024

Parkinson’s disease is characterized by the selective degeneration of dopamine neurons in nigrostriatal pathway and deficiency striatum. The precise reasons behind specific these remain largely elusive. Genetic investigations have identified over 20 causative PARK genes 90 genomic risk loci associated with both familial sporadic disease. Notably, several are linked to synaptic vesicle recycling process, particularly clathrin-mediated endocytosis pathway. This suggests that impaired might represent an early feature disease, followed axonal eventual loss cell bodies midbrain via a “dying back” mechanism. Recently, new animal cellular models disease-linked mutations affecting endocytic been created extensively characterized. These faithfully recapitulate certain disease-like features at animal, circuit, levels, exhibit defects membrane trafficking, further supporting findings from human genetics clinical studies. In this review, we will first summarize molecular two clathrin uncoating proteins: auxilin ( DNAJC6 / PARK19 ) synaptojanin 1 SYNJ1 PARK20 ). mouse carrying gene phenocopy each other terminal pathology display potent synergistic effect. Subsequently, delve into involvement endocytosis-related proteins (GAK, endophilin A1, SAC2/INPP5F, synaptotagmin-11), as factors through genome-wide association studies, pathogenesis. We also explore direct or indirect roles some common (alpha-synuclein (PARK1/4), Parkin (PARK2), LRRK2 (PARK8)) trafficking. Additionally, discuss emerging novel functions downstream traffic pathways, autophagy. Given dysfunction considered event deeper understanding mechanisms underlying trafficking may unveil targets for diagnosis development interventional therapies Future research should aim elucidate why generalized leads

Язык: Английский

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Enediol ligands-assembled nitrogen vacancies-g-C3N5@BiOBr for cathodic photoelectrochemical detection of dopamine

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112688 - 112688

Опубликована: Янв. 1, 2025

Язык: Английский

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Development of Fluorescence-Based Method for Dopamine Determination Using o-Phthaldialdehyde and 3-Mercaptopropyltriethoxysilane

Sensors, Год журнала: 2025, Номер 25(6), С. 1729 - 1729

Опубликована: Март 11, 2025

Nanomaterials and sensors play an important role in modern technologies, including medical diagnostics biochemical research. This work presents the possibility of using o-Phthaldialdehyde (OPA) combination with 3-mercaptopropyltriethoxysilane (MPTES) to develop a dopamine-responsive sensor. During experiment, these materials were used at different pH ratios determine optimal parameters for obtaining high fluorescence intensity reaction product. The data obtained demonstrate linear relationship between response (λex/λem = 340/460 nm) OPA/MPTES dopamine concentration range 0.1–3.0 µM 8, detection limit was 8.7 nM. results confirm potential as sensing component dopamine.

Язык: Английский

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In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Neurochemical signals like dopamine (DA) play a crucial role in variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex networks has been hindered by the challenge detecting multiple neurochemicals vivo simultaneously. To overcome this limitation, we developed single-protein chemigenetic DA sensor, HaloDA1.0, which combines cpHaloTag-chemical dye approach G protein-coupled receptor activation-based (GRAB) strategy, providing high sensitivity for DA, sub-second response kinetics, an extensive spectral range from far-red to near-infrared. When used together existing green red fluorescent neuromodulator sensors, Ca2+ indicators, cAMP optogenetic tools, HaloDA1.0 provides versatility multiplex imaging cultured neurons, slices, behaving animals, facilitating in-depth studies dynamic neurochemical networks.

Язык: Английский

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InSpectro-Gadget: A Tool for Estimating Neurotransmitter and Neuromodulator Receptor Distributions for MRS Voxels

Neuroinformatics, Год журнала: 2024, Номер 22(2), С. 135 - 145

Опубликована: Фев. 22, 2024

Язык: Английский

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Density functional theory analysis of iodine coadsorbed OH-copper phthalocyanine for dopamine sensing

Molecular Physics, Год журнала: 2024, Номер 123(4)

Опубликована: Июль 4, 2024

Density functional theory (DFT) was employed to investigate the sensing behaviour of neurotransmitter dopamine (DA) when interacting with OH-functionalised copper phthalocyanines (CuPcs) and coadsorbed iodine (CuIPc), both in gaseous aqueous media. This study revealed that CuIPc demonstrates a superior capacity for detecting molecules compared CuPc. Within these complexes, hydrogen bonds coordination were observed, playing pivotal role adsorption process. The enhanced electrical conductivity CuPc sheets after adsorption, along high energy iodine-coadsorbed CuPc/DA underscores significance this context. Notably, utilisation significantly enhances response dopamine. In summary, phthalocyanine has emerged as promising material sensors, offering possibilities further advancements field.

Язык: Английский

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Electrochemical Enzyme‐Free Dopamine Sensor Based on Prussian Blue Analogues Oxides and MWCNTs

ChemistrySelect, Год журнала: 2024, Номер 9(41)

Опубликована: Окт. 29, 2024

Abstract Dopamine is an important catecholamine neurotransmitter and its precise determination of great significance in the diagnosis treatment related diseases. This study presents a high‐performance enzyme‐free electrochemical sensor for dopamine based on combination Prussian blue analogues oxides with multi‐walled carbon nanotubes (PBO@CNTs). The prepared PBO@CNTs exhibited increased surface area 49.79 m 2 /g abundant mesoporous nanostructure, which providing numerous electroactive sites. Under optimal conditions, PBO@CNTs/Au high sensitivity 178.34 μA mM −1 cm −2 , broad linear range between 0.30 μM to 8 low detection limit 0.10 μM. It displayed excellent selectivity towards by successive addition various interfering species through chronoamperometry studies. Besides, proposed electrodes enjoyed repeatability, reproducibility long‐term stability. We also demonstrated successful application this serum. results indicated that dopamine‐selective sensors have potential clinical application.

Язык: Английский

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