InSpectro-Gadget: A tool for estimating neurotransmitter and neuromodulator receptor distributions for MRS voxels DOI Creative Commons
Elizabeth McManus, Nils Muhlert, Niall W. Duncan

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Ноя. 5, 2023

Magnetic resonance spectroscopy (MRS) is widely used to estimate concentrations of glutamate and γ-aminobutyric acid (GABA) in specific regions the living human brain. As cytoarchitectural properties differ across brain, interpreting these measurements can be assisted by having knowledge such for MRS region(s) studied. In particular, some likely local neurotransmitter receptor patterns potentially give insights into mechanistic environment GABAand glutamatergic neurons are functioning in. This may particular utility when comparing two or more regions, given that populations substantially them. At same time, studying data from multiple participants timepoints, homogeneity sample becomes relevant, as taken areas with different cytoarchitecture difficult compare. To provide user-defined regions-of-interest, we produced an easy use tool InSpectro-Gadget, interfaces mRNA expression information Allen Human Brain Atlas. Python allows users input masks automatically obtain a graphical overview population found within. includes comparison between where relevant. The receptors subunit genes featured include GABA- classes, along wide range neuromodulators. functionality explained here its demonstrated through set example analyses. available at https://github.com/lizmcmanus/Inspectro-Gadget .

Язык: Английский

InSpectro-Gadget: A tool for estimating neurotransmitter and neuromodulator receptor distributions for MRS voxels DOI Creative Commons
Elizabeth McManus, Nils Muhlert, Niall W. Duncan

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Ноя. 5, 2023

Magnetic resonance spectroscopy (MRS) is widely used to estimate concentrations of glutamate and γ-aminobutyric acid (GABA) in specific regions the living human brain. As cytoarchitectural properties differ across brain, interpreting these measurements can be assisted by having knowledge such for MRS region(s) studied. In particular, some likely local neurotransmitter receptor patterns potentially give insights into mechanistic environment GABAand glutamatergic neurons are functioning in. This may particular utility when comparing two or more regions, given that populations substantially them. At same time, studying data from multiple participants timepoints, homogeneity sample becomes relevant, as taken areas with different cytoarchitecture difficult compare. To provide user-defined regions-of-interest, we produced an easy use tool InSpectro-Gadget, interfaces mRNA expression information Allen Human Brain Atlas. Python allows users input masks automatically obtain a graphical overview population found within. includes comparison between where relevant. The receptors subunit genes featured include GABA- classes, along wide range neuromodulators. functionality explained here its demonstrated through set example analyses. available at https://github.com/lizmcmanus/Inspectro-Gadget .

Язык: Английский

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