Key factors underpinning neuroimmune-metabolic-oxidative (NIMETOX) major depression in outpatients: paraoxonase 1 activity, reverse cholesterol transport, increased atherogenicity, protein oxidation, and differently expressed cytokine networks. DOI Creative Commons
Michaël Maes, Ketsupar Jirakran, Laura de Oliveira Semeão

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Abstract Background Major depressive disorder (MDD) is associated with neuro-immune – metabolic oxidative (NIMETOX) pathways. Aims To examine the connections among NIMETOX pathways in outpatient MDD (OMDD) and without syndrome (MetS); to determine prevalence of aberrations a cohort OMDD patients. Methods We included 67 healthy controls 66 patients we assessed various Results successfully identified subgroup individuals pathways, including diminished lecithin-cholesterol acyltransferase (LCAT), paraoxonase 1 (PON1) activity, reverse cholesterol transport (RCT) activities, elevated atherogenicity, differentially expressed immune networks, advanced oxidation protein products (AOPP). A large part variance (around 44%) atherogenicity indices was AOPP, fasting blood glucose (FBG), PON1 activation. LCAT activity positively correlated negatively FBG, AOPP RCT related R/R 192 genotype FBG larger overall severity (50.4%), suicidal behaviors (27.7%), neuroticism (42.1%) adverse childhood experiences immune-related neurotoxicity, insulin, inversely neuroprotection. Conclusions Many (78.8%) show The features OMDD, illness, neuroticism, behaviors, are caused by intertwined that may exert additional effects depending on whether MetS present or not.

Язык: Английский

Key factors underpinning neuroimmune-metabolic-oxidative (NIMETOX) major depression in outpatients: paraoxonase 1 activity, reverse cholesterol transport, increased atherogenicity, protein oxidation, and differently expressed cytokine networks. DOI Creative Commons
Michaël Maes, Ketsupar Jirakran, Laura de Oliveira Semeão

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Abstract Background Major depressive disorder (MDD) is associated with neuro-immune – metabolic oxidative (NIMETOX) pathways. Aims To examine the connections among NIMETOX pathways in outpatient MDD (OMDD) and without syndrome (MetS); to determine prevalence of aberrations a cohort OMDD patients. Methods We included 67 healthy controls 66 patients we assessed various Results successfully identified subgroup individuals pathways, including diminished lecithin-cholesterol acyltransferase (LCAT), paraoxonase 1 (PON1) activity, reverse cholesterol transport (RCT) activities, elevated atherogenicity, differentially expressed immune networks, advanced oxidation protein products (AOPP). A large part variance (around 44%) atherogenicity indices was AOPP, fasting blood glucose (FBG), PON1 activation. LCAT activity positively correlated negatively FBG, AOPP RCT related R/R 192 genotype FBG larger overall severity (50.4%), suicidal behaviors (27.7%), neuroticism (42.1%) adverse childhood experiences immune-related neurotoxicity, insulin, inversely neuroprotection. Conclusions Many (78.8%) show The features OMDD, illness, neuroticism, behaviors, are caused by intertwined that may exert additional effects depending on whether MetS present or not.

Язык: Английский

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