Exosomes as Biomarkers and Therapeutic Agents in Neurodegenerative Diseases: Current Insights and Future Directions
Sam Dehghani,
Ozgecan Ocakcı,
Pars Tan Hatipoglu
и другие.
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Abstract
Neurodegenerative
diseases
(NDs)
like
Alzheimer’s,
Parkinson’s,
and
ALS
rank
among
the
most
challenging
global
health
issues,
marked
by
substantial
obstacles
in
early
diagnosis
effective
treatment.
Current
diagnostic
techniques
frequently
demonstrate
inadequate
sensitivity
specificity,
whilst
conventional
treatment
strategies
encounter
challenges
related
to
restricted
bioavailability
insufficient
blood–brain
barrier
(BBB)
permeability.
Recently,
exosomes—nanoscale
vesicles
packed
with
proteins,
RNAs,
lipids—have
emerged
as
promising
agents
potential
reshape
therapeutic
approaches
these
diseases.
Unlike
drug
carriers,
they
naturally
traverse
BBB
can
deliver
bioactive
molecules
affected
neural
cells.
Their
molecular
cargo
influence
cell
signaling,
reduce
neuroinflammation,
potentially
slow
neurodegenerative
progression.
Moreover,
exosomes
serve
non-invasive
biomarkers,
enabling
precise
while
allowing
real-time
disease
monitoring.
Additionally,
engineered
exosomes,
loaded
molecules,
enhance
this
capability
targeting
diseased
neurons
overcoming
barriers.
By
offering
enhanced
reduced
immunogenicity,
an
ability
bypass
physiological
limitations,
exosome-based
present
a
transformative
advantage
over
existing
approaches.
This
review
examines
multifaceted
role
of
NDDs,
emphasizing
their
capabilities,
intrinsic
functions,
advanced
vehicles.
Язык: Английский
Present and future use of exosomes containing proteins and RNAs in neurodegenerative diseases for synaptic function regulation: A comprehensive review
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
280, С. 135826 - 135826
Опубликована: Сен. 23, 2024
Neurodegenerative
diseases
(NDDs)
are
increasingly
prevalent
with
global
aging,
demanding
effective
treatments.
Exosomes,
which
contain
biological
macromolecules
such
as
RNA
(including
miRNAs)
and
proteins
like
α-synuclein,
tau,
amyloid-beta,
gaining
attention
innovative
therapeutics.
This
comprehensive
review
systematically
explores
the
potential
roles
of
exosomes
in
NDDs,
a
particular
focus
on
their
role
synaptic
dysfunction.
We
present
pathophysiology
NDDs
discuss
mechanisms
exosome
formation,
secretion,
action.
Subsequently,
we
different
types
Alzheimer's
disease
Parkinson's
disease,
special
regulation
function.
In
addition,
explore
use
biomarkers,
well
challenges
opportunities
clinical
application.
provide
perspectives
future
research
directions
development
trends
to
more
understanding
guidance
for
application
treatment
NDDs.
conclusion,
rich
macromolecules,
novel
therapeutic
strategy,
have
opened
up
new
possibilities
brought
hope
patients.
Язык: Английский