No reliable gray matter alterations in idiopathic dystonia DOI Creative Commons
Zhenyu Wang, Fei Chen,

Haihua Sun

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Март 3, 2025

Background The structural brain abnormalities associated with idiopathic dystonia (ID) remain inadequately understood. Previous voxel-based morphometry (VBM) studies examining whole-brain gray matter (GM) volume alterations in patients ID have reported inconsistent and occasionally contradictory findings. Methods We performed a coordinate-based meta-analysis (CBMA) using the latest seed-based d mapping permutation of subject images (SDM-PSI) technique to identify consistent GM at level. Additionally, meta-regression analyses were conducted explore potential moderating effects age, gender, disease duration on volume. Results CBMA incorporated 27 VBM studies, comprising 32 datasets total 840 834 healthy controls. Our analysis did not or reliable ID. robustness these findings was confirmed through jackknife sensitivity analysis. Meta-regression revealed that significantly influenced right insula. Conclusion Based best practice guidelines for CBMA, we utilized most recent SDM-PSI algorithm perform new included larger group individuals However, contrast previous CBMAs, observe any suggest assessed by as an imaging marker may be reliable. This could attributed being functional disorder, inconsistency demographic clinical variations, differences protocols methods, small sample sizes. It is imperative control characteristics, employ standardized methodologies, enhance sizes future research.

Язык: Английский

No reliable gray matter alterations in idiopathic dystonia DOI Creative Commons
Zhenyu Wang, Fei Chen,

Haihua Sun

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Март 3, 2025

Background The structural brain abnormalities associated with idiopathic dystonia (ID) remain inadequately understood. Previous voxel-based morphometry (VBM) studies examining whole-brain gray matter (GM) volume alterations in patients ID have reported inconsistent and occasionally contradictory findings. Methods We performed a coordinate-based meta-analysis (CBMA) using the latest seed-based d mapping permutation of subject images (SDM-PSI) technique to identify consistent GM at level. Additionally, meta-regression analyses were conducted explore potential moderating effects age, gender, disease duration on volume. Results CBMA incorporated 27 VBM studies, comprising 32 datasets total 840 834 healthy controls. Our analysis did not or reliable ID. robustness these findings was confirmed through jackknife sensitivity analysis. Meta-regression revealed that significantly influenced right insula. Conclusion Based best practice guidelines for CBMA, we utilized most recent SDM-PSI algorithm perform new included larger group individuals However, contrast previous CBMAs, observe any suggest assessed by as an imaging marker may be reliable. This could attributed being functional disorder, inconsistency demographic clinical variations, differences protocols methods, small sample sizes. It is imperative control characteristics, employ standardized methodologies, enhance sizes future research.

Язык: Английский

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