Emerging therapies for osteoporosis: a narrative review of multifaceted interventions involving plant- and animal-derived bioactive peptides DOI
Li Sun, Rui Du,

Jinze Liu

и другие.

Aging advances., Год журнала: 2025, Номер 2(2), С. 54 - 61

Опубликована: Апрель 8, 2025

Osteoporosis is a chronic bone disease associated with aging, characterized by decreased mineral density and increased fracture risk, profoundly impacting the quality of life older individuals. Despite significant advancements in modern medicine, existing treatments for osteoporosis are often accompanied substantial side effects that limit their long-term use. In recent years, use plant-derived animal-derived bioactive peptides has emerged as promising due to high safety profile, low effects, natural health benefits. This review aims explore pathogenesis osteoporosis, extraction, isolation, purification peptides, antiosteoporotic mechanisms. Additionally, this seeks provide safer more effective solutions prevention treatment The plant- mediated through multiple mechanisms, including promotion osteoblast proliferation differentiation, inhibition osteoclast activity, modulation calcium phosphorus metabolism, reduction oxidative stress, suppression inflammatory responses. For example, certain promote formation activating Wnt/β-catenin signaling pathway, while others reduce resorption inhibiting RANKL/RANK/OPG axis. addition, some enhance regulating absorption exerting antioxidant functions. However, currently, there insufficient clinical evidence application require further validation trials. Plant- hold potential an emerging antiosteoporosis strategy, particularly among With continued research into mechanisms action advancement trials, these anticipated become important tools improving reducing risk population. Future studies should develop programs.

Язык: Английский

Emerging therapies for osteoporosis: a narrative review of multifaceted interventions involving plant- and animal-derived bioactive peptides DOI
Li Sun, Rui Du,

Jinze Liu

и другие.

Aging advances., Год журнала: 2025, Номер 2(2), С. 54 - 61

Опубликована: Апрель 8, 2025

Osteoporosis is a chronic bone disease associated with aging, characterized by decreased mineral density and increased fracture risk, profoundly impacting the quality of life older individuals. Despite significant advancements in modern medicine, existing treatments for osteoporosis are often accompanied substantial side effects that limit their long-term use. In recent years, use plant-derived animal-derived bioactive peptides has emerged as promising due to high safety profile, low effects, natural health benefits. This review aims explore pathogenesis osteoporosis, extraction, isolation, purification peptides, antiosteoporotic mechanisms. Additionally, this seeks provide safer more effective solutions prevention treatment The plant- mediated through multiple mechanisms, including promotion osteoblast proliferation differentiation, inhibition osteoclast activity, modulation calcium phosphorus metabolism, reduction oxidative stress, suppression inflammatory responses. For example, certain promote formation activating Wnt/β-catenin signaling pathway, while others reduce resorption inhibiting RANKL/RANK/OPG axis. addition, some enhance regulating absorption exerting antioxidant functions. However, currently, there insufficient clinical evidence application require further validation trials. Plant- hold potential an emerging antiosteoporosis strategy, particularly among With continued research into mechanisms action advancement trials, these anticipated become important tools improving reducing risk population. Future studies should develop programs.

Язык: Английский

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