Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 596 - 606.e8
Опубликована: Янв. 1, 2024
Язык: Английский
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 596 - 606.e8
Опубликована: Янв. 1, 2024
Язык: Английский
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 22, 2024
Alzheimer's disease (AD) is a prevalent irreversible neurodegenerative condition marked by gradual cognitive deterioration and neuronal loss. The mammalian Ste20-like kinase (MST1)–Hippo pathway pivotal in regulating cell apoptosis, immune response, mitochondrial function, oxidative stress. However, the association between MST1 function AD remains unknown. Therefore, this study investigates effect of on damage impairment homeostasis AD. In study, 4- 7-month-old 5xFAD mice were selected to simulate early middle stages AD, respectively; age-matched wild-type served as controls for comparative analysis. Adeno-associated virus (AAV) was injected into hippocampus mice. Four weeks post-injection, indicators, morphology, dynamics, stress, ATP, apoptosis-related indicators evaluated. Additionally, RNA-sequencing performed hippocampal tissue MST1-knockdown Subsequently, Gene Ontology (GO) enrichment Kyoto Encyclopedia Genes Genomes (KEGG) analyses differentially expressed genes elucidate potential mechanism MST1. vitro studies investigate effects SH-SY5Y model viability validate underlying molecular mechanisms. overexpression accelerated degeneration deficits vivo while promoting stress damage. Similarly, vitro, facilitated apoptosis dysfunction. knockdown chemical inactivation reduced decline, dysfunction, degeneration. Mechanistically, regulated transcription genes, including MT-ND4L, MT-ATP6, MT-CO2, binding PGC1α. Moreover, influenced cellular through PI3K-Akt-ROS pathway, ultimately disrupting mediating Cumulatively, these results suggest that primarily regulates DNA levels interacting with PGC1α modulates homeostasis. This discovery can be exploited potentially enhance energy metabolism pathways targeting MST1, offering novel therapeutic targets treating
Язык: Английский
Процитировано
3Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 225 - 240
Опубликована: Янв. 1, 2025
Процитировано
0Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 199 - 224
Опубликована: Янв. 1, 2025
Процитировано
0Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 277 - 293
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Neurotherapeutics, Год журнала: 2024, Номер 21(1), С. e00332 - e00332
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
0Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 596 - 606.e8
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0