Exploring the Role of Neuromodulation in Neurodegenerative Disorders: Insights from Alzheimer's Disease and Parkinson's Disease
Brain Disorders,
Год журнала:
2025,
Номер
unknown, С. 100187 - 100187
Опубликована: Фев. 1, 2025
Язык: Английский
Doraemon’s Gadget Lab: Unpacking Human Needs and Interaction Design in Speculative Technology
Опубликована: Апрель 23, 2025
Язык: Английский
A Bioelectric Router for Adaptive Isochronous Neurostimulation
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Abstract
Objective
Multipolar
intracranial
electrical
brain
stimulation
(iEBS)
is
a
method
that
has
potential
to
improve
clinical
applications
of
mono-
and
bipolar
iEBS.
Current
tools
for
researching
multipolar
iEBS
are
proprietary,
can
have
high
entry
costs,
lack
flexibility
in
managing
different
parameters
electrodes,
include
features
unnecessary
the
requisite
exploratory
research.
This
factor
limiting
progress
understanding
applying
effectively.
To
address
these
challenges,
we
developed
Bioelectric
Router
Adaptive
Isochronous
Neuro
(BRAINS)
board.
Approach
The
BRAINS
board
cost-effective
customizable
device
designed
facilitate
experiments
across
16-channel
electrode
array
using
common
research
setups.
interfaces
with
microcontroller,
allowing
users
configure
each
channel
cathodal
or
anodal
input,
establish
grounded
connection,
maintain
floating
state.
design
prioritizes
ease
integration
by
leveraging
standard
like
microcontroller
an
analog
signal
isolators
while
providing
options
customize
setups
according
experimental
conditions.
It
also
ensures
output
isolation,
reduces
noise,
supports
remote
configuration
changes
rapid
switching
states.
test
efficacy
board,
performed
bench-top
validation
monopolar,
bipolar,
regimes.
same
regimes
were
tested
vivo
mouse
primary
visual
cortex
measured
Neuropixel
recordings.
Main
Results
demonstrates
no
meaningful
differences
Root
Mean
Square
Error
(RMSE)
noise
signal-to-noise
ratio
compared
baseline
performance
isolated
stimulator
alone.
at
rate
up
600
Hz
without
introducing
residual
enabling
high-frequency
necessary
temporally
multiplexed
stimulation.
Significance
represents
significant
advancement
user-friendly,
customizable,
open
source,
tool
capable
conducting
sophisticated,
reproducible,
finely
controlled
experiments.
With
capacity
effectively
real-time
information
processing
efficient
parameter
exploration
enhance
both
on
enable
improved
use
closed-loop
Язык: Английский
Integrating Data Mining with Transcranial Focused Ultrasound to Refine Neuralgia Treatment Strategies
Mascella Raffaele,
Marimuthu Karuppiah
JOURNAL OF HIGH-FREQUENCY COMMUNICATION TECHNOLOGIES,
Год журнала:
2025,
Номер
03(02), С. 299 - 314
Опубликована: Апрель 22, 2025
The
heterogeneity
in
the
causes
and
responses
to
pain
patients
makes
neuralgia,
a
condition
defined
by
persistent
severe
nerve
pain,
challenging
treatment
problem.
However,
inconsistent
therapeutic
results
long
patient
suffering
are
common
of
traditional
therapy
procedures
that
depend
on
generic
methodologies.
This
research
presents
technological
framework
combines
data
mining
transcranial
focused
ultrasound
(tFUS)
improve
strategies
for
with
aim
overcoming
these
limitations.
first
step
proposed
system
is
gather
multimodal
datasets
have
been
preprocessed
using
normalization,
noise
reduction,
feature
extraction
methods.
These
sets
include
patient-reported
ratings,
clinical
history,
brain
imaging
(fMRI,
EEG).
Next,
algorithms
such
as
clustering
classification
used
find
patterns
activity
attributes.
Dimensionality
reduction
methods
variational
autoencoders
(VAEs)
make
complex
associations
easier
observe
understand.
Optimal
tFUS
parameters
frequency,
intensity,
focal
depth
predicted
individual
machine
learning
models
(MLM),
gradient-boosted
decision
trees
(GBDT)
Random
Forests
(RF).
Based
biomarkers
detected,
predictions
direct
deployment
specific
area
brain.
During
treatment,
real-time
neural
feedback
systems
track
patients’
reactions,
allowing
adaptive
alterations
boost
effectiveness.
Incorporating
post-treatment
into
an
iterative
loop
allows
continued
improvement
prediction
future
sessions.
An
increase
measures
was
observed
compared
techniques,
greater
neuroplasticity
fewer
side
effects
when
evaluated
from
neuralgia.
method
achieves
97.86%
97.14%,
34.61%
37.83%,
98.64%
96.36%,
effectiveness
safety
97.04%
98.67%.
Язык: Английский
Advancing Brainwave Therapy for Trauma: Precision Stimulation with Deep Brain Sound Technology
Опубликована: Авг. 26, 2024
Objective
This
study
aims
to
evaluate
the
efficacy
and
safety
of
Deep
Brain
Sound
Stimulation
(DBSS)
as
a
novel
treatment
for
trauma-related
disorders,
specifically
Post-Traumatic
Stress
Disorder
(PTSD)
Developmental
Trauma
(DTD).
The
research
focuses
on
user-reported
outcomes
DBSS
therapy
delivered
via
mobile
application.
Method
employs
precise
auditory
stimulation
targeted
at
specific
brain
regions
involved
in
trauma
response,
such
amygdala,
hippocampus,
prefrontal
cortex.
Data
were
collected
from
267
users
who
purchased
through
Apple
App
Store.
User
feedback
regarding
effectiveness
satisfaction
with
was
analyzed.
Results
majority
reported
significant
improvements
emotional
regulation,
reduction
hyperarousal,
stabilization
interpersonal
relationships.
well-tolerated,
minimal
side
effects
reported.
Despite
absence
traditional
clinical
trials,
findings
suggest
that
could
be
promising
non-invasive
disorders.
Conclusions
shows
potential
an
innovative
PTSD
DTD
by
targeting
key
neurobiological
mechanisms
underlying
trauma.
Future
studies
should
aim
confirm
these
results
trials
further
refine
broader
Язык: Английский
The impact of 8 weeks of Heidelberg Ballschule games on the motor proficiency and visual-motor skills of 7-9 year-old female students
International Journal of Adolescence and Youth,
Год журнала:
2024,
Номер
29(1)
Опубликована: Дек. 2, 2024
The
study
investigated
the
effects
of
Heidelberg
Ballschule
motor
proficiency
and
visual-motor
skills
7–9
year-old
girls.
A
sample
30
girls
participated
in
a
semi-experimental
study,
with
pre-test
post-test
evaluations
conducted.
Bruininks-Oseretsky
test
were
used
to
assess
skills.
Results
showed
significant
improvement
both
among
experimental
group
compared
control
(p
<
0.05).
These
findings
highlight
substantial
benefits
Games
enhancing
girl's
recommends
incorporating
these
ball
games
promote
children's
overall
visual
development.
Язык: Английский