The role of the gut microbiome in Alzheimer's disease pathophysiology
Current Opinion in Neurology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
Purpose
of
review
The
present
aims
to
provide
an
overview
the
existing
understanding
role
gut
microbiome
in
Alzheimer's
disease
pathophysiology.
Recent
findings
research
has
highlighted
significant
pathogenesis
via
gut-brain
axis.
However,
precise
mechanisms
by
which
and
its
microbial
metabolites
influence
brain
function
are
not
clearly
understood.
Various
factors,
such
as
diet,
drugs,
lifestyle,
stress,
infections
can
provoke
imbalance
homeostasis,
known
dysbiosis.
This
dysbiosis
impacts
intestinal
blood-brain
barrier
permeability,
elevating
pro-inflammatory
cytokines
contributing
neurodegeneration.
Moreover,
generates
neurotransmitters,
amyloids,
neurotoxins,
metabolites,
may
play
a
systemic
inflammation
disruption
physiological
barriers.
Summary
In
past
decade,
advancements
analysis
technologies
bioinformatics
have
significantly
enhanced
our
disease.
plays
pivotal
regulatory
progression
disease,
closely
interacts
with
pathogenesis,
encompassing
inflammation,
amyloidosis,
neurodegeneration,
tauopathy,
co-pathologies.
Язык: Английский
The regulatory mechanism of intermittent fasting and probiotics on cognitive function by the microbiota‐gut‐brain axis
Journal of Food Science,
Год журнала:
2025,
Номер
90(3)
Опубликована: Март 1, 2025
Abstract
Intermittent
fasting
(IF)
is
an
eating
pattern
that
promotes
health
and
cognitive
improvement
through
periodic
eating.
It
has
been
shown
to
enhance
neuroplasticity
reduce
oxidative
stress
inflammation.
Recent
studies
have
demonstrated
probiotic
supplementation
enhances
performance
by
modulating
gut
microbiota
composition
increasing
short‐chain
fatty
acid
production,
which
in
turn
neurogenesis
synaptic
plasticity.
The
microbiota‐gut‐brain
axis
(MGBA)
the
communication
bridge
between
brain,
influencing
function
immune,
endocrine,
nervous
systems.
combination
of
probiotics
IF
may
exert
complementary
effects
on
function,
with
enhancing
microbial
diversity
metabolic
efficiency,
while
further
modulate
barrier
integrity
neurotransmitter
synthesis.
This
review
critically
examines
interplay
via
MGBA,
identifying
key
mechanisms
potential
therapeutic
strategies
remain
underexplored
current
research.
Язык: Английский
Interplay of Neuroinflammation and Gut Microbiota Dysbiosis in Alzheimer’s Disease Using Diffusion Kurtosis Imaging Biomarker in 3 × Tg-AD Mouse Models
ACS Chemical Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
The
relationship
between
alterations
in
brain
microstructure
and
dysbiosis
of
gut
microbiota
Alzheimer's
disease
(AD)
has
garnered
increasing
attention,
although
the
functional
implications
these
changes
are
not
yet
fully
elucidated.
This
research
examines
how
neuroinflammation,
systemic
inflammation,
interact
male
3
×
Tg-AD
B6129SF1/J
wild-type
(WT)
mice
at
6
months-old
(6-MO)
12
(12-MO).
Employing
a
combination
behavioral
assessments,
diffusion
kurtosis
imaging
(DKI),
profiling,
cytokine
analysis,
short-chain
fatty
acids
(SCFAs),
immunohistochemistry,
we
explored
progression
AD-related
pathology.
Significant
memory
impairments
AD
both
assessed
ages
were
correlated
with
altered
DKI
parameters
that
suggest
neuroinflammation
microstructural
damage.
We
observed
elevated
levels
pro-inflammatory
cytokines,
such
as
IL-1β,
IL-6,
TNFα,
IFN-γ,
serum,
which
associated
increased
activity
microglia
astrocytes
regions
critical
for
memory.
Although
analysis
did
reveal
significant
alpha
diversity,
it
show
notable
differences
beta
diversity
diminished
Firmicutes/Bacteroidetes
(F/B)
ratio
12-MO.
Furthermore,
reduction
six
kinds
SCFAs
identified
two
time
points
6-MO
12-MO,
indicating
widespread
disruption
microbial
metabolism.
These
findings
underscore
complex
bidirectional
inflammation
AD,
highlighting
gut-brain
axis
crucial
factor
progression.
study
emphasizes
potential
integrating
metrics,
SCFA
to
enhance
our
understanding
pathology
identify
new
therapeutic
targets.
Язык: Английский
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota
Experimental and Molecular Pathology,
Год журнала:
2025,
Номер
142, С. 104964 - 104964
Опубликована: Апрель 8, 2025
The
gut-lung
axis,
a
vital
signaling
network
linking
the
gastrointestinal
and
pulmonary
systems,
regulates
immune
responses
progression
of
respiratory
diseases.
Nutritional
components
can
modulate
gut
microbiome
regulate
synthesis
critical
intestinal
microbial
metabolites,
which
are
essential
for
maintaining
homeostasis
supporting
health.
Conversely,
poor
dietary
habits
exacerbate
asthma
other
conditions
through
modulation
systemic
inflammation
responses.
Dietary
interventions,
such
as
Mediterranean
diet,
reported
to
restore
balance
improve
health
by
increasing
production
anti-inflammatory
potentiating
responses,
preserving
epithelial
barrier
integrity.
In
contrast,
Western
patterns,
characterized
high
fat
low
fiber
intake,
disrupt
diversity,
resulting
in
increased
levels
pro-inflammatory
metabolites
that
aggravate
airway
severity.
This
review
aimed
elucidate
mechanisms
underlying
regulatory
effects
microbes
their
on
asthma.
Additionally,
previous
findings
related
axis
have
been
summarized,
providing
insights
into
potential
therapeutic
strategies
management.
Язык: Английский
Gut microbiota dysbiosis and neurologic diseases: New Horizon with potential diagnostic and therapeutic impact
Neurotherapeutics,
Год журнала:
2024,
Номер
21(6), С. e00478 - e00478
Опубликована: Окт. 1, 2024
Язык: Английский
The blood metabolome of cognitive function and brain health in middle-aged adults – influences of genes, gut microbiome, and exposome
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
ABSTRACT
Increasing
evidence
suggests
the
involvement
of
metabolic
alterations
in
neurological
disorders,
including
Alzheimer’s
disease
(AD),
and
highlights
significance
peripheral
metabolome,
influenced
by
genetic
factors
modifiable
environmental
exposures,
for
brain
health.
In
this
study,
we
examined
1,387
metabolites
plasma
samples
from
1,082
dementia-free
middle-aged
participants
population-based
Rotterdam
Study.
We
assessed
relation
with
general
cognition
(G-factor)
magnetic
resonance
imaging
(MRI)
markers
using
linear
regression
estimated
variance
these
explained
genes,
gut
microbiome,
lifestyle
factors,
common
clinical
comorbidities,
medication
gradient
boosting
decision
tree
analysis.
Twenty-one
one
metabolite
were
significantly
associated
total
volume
white
matter
lesions,
respectively.
Fourteen
showed
significant
associations
G-factor,
ergothioneine
exhibiting
largest
effect
(adjusted
mean
difference
=
0.122,
P
4.65x10
-7
).
Associations
nine
14
replicated
an
independent,
older
cohort.
The
signature
incident
AD
replication
cohort
resembled
that
discovery
cohort,
emphasizing
potential
relevance
identified
to
pathogenesis.
Lifestyle,
variables,
most
important
determining
metabolites’
blood
levels,
lifestyle,
explaining
up
28.6%
variance.
Smoking
was
ten
linked
while
diabetes
antidiabetic
13
MRI
markers,
N-lactoyltyrosine.
Antacid
strongly
affected
levels.
Mediation
analysis
revealed
lower
levels
may
partially
mediate
negative
effects
antacids
on
(31.5%).
Gut
microbial
more
(beta-cryptoxanthin,
imidazole
propionate),
suggesting
they
be
involved
later
process.
detailed
results
how
multiple
affect
cognition-
imaging-related
help
identify
new
prevention
strategies.
Язык: Английский