A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases

Viruses, Год журнала: 2025, Номер 17(4), С. 562 - 562

Опубликована: Апрель 14, 2025

Tripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity. This ubiquitous participation in fundamental aspects biology has made TRIM a focus study many fields illuminated the negative impact they exert when functioning improperly. Disruption function been linked to success various pathogens separately occurrence development several neurodegenerative diseases, making appealing candidate for novel therapeutic approaches. Here, we review current findings on demonstrate their analogous properties distinct viral infection central nervous system (CNS) disorders. We also examine recent advancements drug targeted degradation as potential strategies TRIM-mediated treatments discuss implications these technologies have future research directions.

Язык: Английский

Emerging approaches to bridging discovery science with clinical care in Alzheimer's disease

Neurotherapeutics, Год журнала: 2025, Номер 22(3), С. e00589 - e00589

Опубликована: Апрель 1, 2025

Язык: Английский