Emerging approaches to bridging discovery science with clinical care in Alzheimer's disease DOI Creative Commons
Subhash C. Sinha, Li Gan, Andrew A. Pieper

и другие.

Neurotherapeutics, Год журнала: 2025, Номер 22(3), С. e00589 - e00589

Опубликована: Апрель 1, 2025

Язык: Английский

Novel Triazole-Substituted Imidazo[1,2-a]Pyrimidine Compounds as cGAS inhibitors DOI Creative Commons

Tao-Qian Zhao,

Steven H. Liang

ACS Medicinal Chemistry Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

This patent application presents the discovery and characterization of a novel series triazole-substituted imidazo[1,2-a]pyrimidine compounds as selective cGAS inhibitors. These effectively suppress enzymatic activity modulate downstream STING signaling, demonstrating potential for treating autoimmune inflammatory diseases driven by aberrant cytosolic DNA sensing.

Язык: Английский

Процитировано

0
Emerging approaches to bridging discovery science with clinical care in Alzheimer's disease DOI Creative Commons
Subhash C. Sinha, Li Gan, Andrew A. Pieper

и другие.

Neurotherapeutics, Год журнала: 2025, Номер 22(3), С. e00589 - e00589

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0