Impulse control deficits among patients with nonsuicidal self-injury: a mediation analysis based on structural imaging DOI Open Access

Xie Ya,

Sichu Wu, Jian Li

и другие.

Journal of Psychiatry and Neuroscience, Год журнала: 2025, Номер 50(2), С. E73 - E84

Опубликована: Март 4, 2025

Nonsuicidal self-injury (NSSI) is posited to arise from a complex interaction of biopsychosocial factors, with impulsivity playing critical role. Given that current research on the neural mechanisms underlying this hypothesis remains inconsistent and limited in scope, we sought explore how NSSI behaviours are associated resulting structural brain alterations. We recruited patients healthy controls 11 psychiatric hospitals. assessed differences impulse control between 2 groups using Barratt Impulsiveness Scale version Attention Network Test. also conducted T 1-weighted magnetic resonance imaging (MRI) diffusion tensor imaging. Finally, analyzed associations among structure, psychological characteristics, self-injurious behaviour NSSI. included 293 140 controls. Among them, 182 95 underwent MRI Patients showed increased alerting function, strongest correlation frequency motor impulsivity. Compared controls, exhibited decreased grey matter volume white volume, no significant difference cortical thickness. Pathway analysis demonstrated significantly mediated association right superior frontal gyrus inferior parietal lobe. When examining connecting fibre tracts frontoparietal area, integrity microstructure cingulum, corona radiata, splenium corpus callosum. Accurately measuring executive linked challenging cognitive behavioural tasks, as impulsive tendencies during occurrence not effectively captured. Our findings suggested impulsivity, prominent psychopathological characteristic NSSI, primarily modulated by regions. These results provide empirical neuroimaging evidence for impaired observed

Язык: Английский

Impulse control deficits among patients with nonsuicidal self-injury: a mediation analysis based on structural imaging DOI Open Access

Xie Ya,

Sichu Wu, Jian Li

и другие.

Journal of Psychiatry and Neuroscience, Год журнала: 2025, Номер 50(2), С. E73 - E84

Опубликована: Март 4, 2025

Nonsuicidal self-injury (NSSI) is posited to arise from a complex interaction of biopsychosocial factors, with impulsivity playing critical role. Given that current research on the neural mechanisms underlying this hypothesis remains inconsistent and limited in scope, we sought explore how NSSI behaviours are associated resulting structural brain alterations. We recruited patients healthy controls 11 psychiatric hospitals. assessed differences impulse control between 2 groups using Barratt Impulsiveness Scale version Attention Network Test. also conducted T 1-weighted magnetic resonance imaging (MRI) diffusion tensor imaging. Finally, analyzed associations among structure, psychological characteristics, self-injurious behaviour NSSI. included 293 140 controls. Among them, 182 95 underwent MRI Patients showed increased alerting function, strongest correlation frequency motor impulsivity. Compared controls, exhibited decreased grey matter volume white volume, no significant difference cortical thickness. Pathway analysis demonstrated significantly mediated association right superior frontal gyrus inferior parietal lobe. When examining connecting fibre tracts frontoparietal area, integrity microstructure cingulum, corona radiata, splenium corpus callosum. Accurately measuring executive linked challenging cognitive behavioural tasks, as impulsive tendencies during occurrence not effectively captured. Our findings suggested impulsivity, prominent psychopathological characteristic NSSI, primarily modulated by regions. These results provide empirical neuroimaging evidence for impaired observed

Язык: Английский

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