Fatigue and associated factors in 172 patients with McArdle disease: An international web-based survey DOI Creative Commons
A. Slipsager, Linda Kahr Andersen, Nicol C. Voermans

и другие.

Neuromuscular Disorders, Год журнала: 2023, Номер 34, С. 19 - 26

Опубликована: Ноя. 10, 2023

McArdle disease is an autosomal recessive inherited caused by pathogenic variants in the PYGM gene, resulting virtual absence of myophosphorylase enzyme skeletal muscle. Patients experience physical activity intolerance, muscle pain, and fatigue. This study aimed to investigate other fatigue domains with Multidimensional Fatigue Inventory (MFI-20) along investigation potential contributing factors, including relevant lifestyle-related factors. We conducted a survey international cohort patients disease. The included questions on demographics disease-related symptoms, questionnaires: MFI-20, Insomnia Severity Index (ISI), International Physical Activity Questionnaire Short-Form (IPAQ-SF). One hundred seventy-four responses were data analyses. found relatively high scores all five (general (12.9 ± 2.2), mental (10.1 4.1), (13.7 reduced (12.1 motivation (10.4 3.4)). associated symptom severity (p < 0.005), lower levels (assessed IPAQ-SF) 0.05), poor sleep ISI) 0.05). These findings call for clinical focus future research into fatigue, health

Язык: Английский

Physical Activity and Sedentary Behaviour in People with Myasthenia Gravis: A Cross-Sectional Study DOI
Tahlia Alsop, Katrina Williams, Sjaan R. Gomersall

и другие.

Journal of Neuromuscular Diseases, Год журнала: 2021, Номер 9(1), С. 137 - 146

Опубликована: Окт. 9, 2021

Despite improvements in the medical management of myasthenia gravis (MG) recent years, patients continue to report poor health and wellbeing outcomes such as high levels fatigue, reduced quality life (QoL), walking limitation lowered balance confidence. Physical activity has been shown be associated with these other populations, however, there limited research adults MG.To describe physical sedentary behaviour MG explore associations between behaviours QoL, confidence limitation.A self-report online survey was used assess activity, behaviour, MG. Multiple linear regression examine descriptive statistics were analyse participant characteristics, behaviour.Eighty-five included (mean age 48±16 years). Over half participants (n = 53, 62.4%) reported sufficient meet public guidelines. Participants an average 9 h/day time 9.0±3.5). fatigue (R2 0.196), QoL 0.330), 0.305) 0.304) significantly (p < 0.05) positively correlated, no found for behaviour. When patterns combined, lower 0.213), higher 0.364), 0.341) 0.279) observed who had greater (> 150 mins/week) (< 10 h/day).Higher is favorable Further required ascertain whether may appropriate target intervention improve this population.

Язык: Английский

Процитировано

10
Therapeutic Effect and Side Effects of Pharmacotherapy in Patients With Parkinson Disease and Myasthenia Gravis: A Systematic Review of Case Reports and Case Series Studies DOI
Haoyu Xie,

Yadi Liu,

Cynthia Schmidt

и другие.

Clinical Therapeutics, Год журнала: 2024, Номер 46(3), С. 275 - 284

Опубликована: Фев. 14, 2024

Язык: Английский

Процитировано

1
Quality of life in hypokalemic periodic paralysis – a survey DOI Creative Commons
Sonja Holm‐Yildiz, Thomas Krag,

Tina Dysgaard

и другие.

Neuromuscular Disorders, Год журнала: 2024, Номер 41, С. 24 - 28

Опубликована: Май 29, 2024

Primary hypokalemic periodic paralysis (HypoPP) is a skeletal muscle channelopathy most commonly caused by pathogenic variants in the calcium channel gene, CACNA1S. HypoPP can present with attacks of and/or permanent weakness. Previous studies have shown that patients impaired quality life (QoL). In this cross-sectional study, we aimed to describe QoL CACNA1S using The Individualized Neuromuscular Quality Life (INQoL) questionnaire, validated tool measure neuromuscular diseases (higher score, worse QoL). We showed weakness and fatigue were symptoms greatest impact on participants' lives "activities", domain INQoL, was affected HypoPP. Furthermore, total INQoL score increased age. Low primarily driven progressive not paralysis, although half participants reported challenged their daily life. results suggest special attention should be given

Язык: Английский

Процитировано

1
Effect of Exercise on β-Endorphin and Its Receptors in Myasthenia Gravis Patients DOI
Gyanesh Tripathi, U. K. Misra, Jayantee Kalita

и другие.

Molecular Neurobiology, Год журнала: 2023, Номер 60(6), С. 3010 - 3019

Опубликована: Фев. 13, 2023

Язык: Английский

Процитировано

3
The Correlation Between Static Fatigue Testing and the Quantitative Myasthenia Gravis Score and Activities of Daily Living Profile DOI Creative Commons

Navdeep Lail,

Gil I. Wolfe,

Laura Herbelin

и другие.

RRNMF Neuromuscular Journal, Год журнала: 2021, Номер 2(5)

Опубликована: Дек. 20, 2021

Fatigue is a common symptom in myasthenia gravis (MG), but both objective and subjective measures of fatigue are poorly studied the disease. We conducted pilot study static testing (SFT) group MG patients, using an isometric quantified muscle analysis computer system. Results from sustained contraction 5 groups 77 patients were correlated to Quantitative Score (QMG) Activities Daily Living Profile (MG-ADL), two commonly used outcome measures. Pearson correlation coefficients for SFT highest (0.33) hand grip QMG MG-ADL. Correlations quite poor proximal ankle dorsiflexion. More work needed develop MG.

Язык: Английский

Процитировано

4
Neurologic Disorders in Women and Sleep DOI
Fidaa Shaib

Neurologic Clinics, Год журнала: 2023, Номер 41(2), С. 297 - 314

Опубликована: Апрель 6, 2023

Язык: Английский

Процитировано

1
Exploring impairments and allied health professional utilisation in people with myasthenia gravis: A cross-sectional study DOI Creative Commons
Neve Cavanagh, Kirstine Shrubsole, Tahlia Alsop

и другие.

Journal of Clinical Neuroscience, Год журнала: 2023, Номер 114, С. 9 - 16

Опубликована: Июнь 3, 2023

Abstract

This study aimed to explore how people with myasthenia gravis experience impairments in vision, dizziness, hearing, and fatigue, these relate balance confidence, community participation, health-related quality of life. Additionally, this investigated the utilisation perception allied health role managing Australian context. Visual hearing impairments, along were found be correlated life participation varying degrees, while visual impairment dizziness confidence. Perception professionals was variable; common barriers better included participant clinicians having poor knowledge around gravis, previous experiences clinicians, uncertainty about clinicians' role, lack awareness that symptoms associated gravis. Further research exploring is recommended, education for disease appropriately access care.

Язык: Английский

Процитировано

1
Fatigue measured with the Multidimensional Fatigue Inventory in a population of intensive care patients at the post-intensive care clinic: A prospective longitudinal study DOI

Maria Willman,

Ing‐Marie Larsson, Ewa Wallin

и другие.

Intensive and Critical Care Nursing, Год журнала: 2023, Номер 80, С. 103570 - 103570

Опубликована: Ноя. 6, 2023

Язык: Английский

Процитировано

1
Relationship Between Fatigue and Quantitative Electromyography Findings in Patients with Myasthenia Gravis DOI Creative Commons

Didem Savaşcı,

Metin Mercan,

Vıldan Yayla

и другие.

Heliyon, Год журнала: 2024, Номер 10(20), С. e39231 - e39231

Опубликована: Окт. 1, 2024

Fatigue is a common complaint among patients with myasthenia gravis (MG). In this study, we investigated the alterations in muscle morphology MG experiencing fatigue using quantitative electromyography (QEMG), and explored relationship between electrophysiological findings severity of both disease.

Язык: Английский

Процитировано

0
Longitudinal relationships between free‐living activities, fatigue, and symptom severity in myasthenia gravis using cohort and individualized models DOI Creative Commons
Hannah L. Dimmick, Gordon Jewett, Lawrence Korngut

и другие.

Muscle & Nerve, Год журнала: 2024, Номер unknown

Опубликована: Окт. 30, 2024

Abstract Introduction/Aims Fluctuating symptoms and fatigue are common issues in myasthenia gravis (MG), but it is unclear if these related to physical activity or sleep patterns. This study sought determine the day‐to‐day relationship between patient‐reported over 12 weeks. Methods Sixteen participants with generalized MG wore a wrist‐mounted accelerometer continuously for duration reported their each evening. Cumulative link mixed models were used analyze whether clinical demographic characteristics, activity, symptom severity period. Three types of constructed: cohort model, model which data was scaled participant, individual models. Results The indicated that higher disease severity, female sex, more comorbidities, less inactive time, lower quantity significantly associated increased ( p < .05). However, within‐participant there almost no significant associations sleep. In models, some showed similar results others opposite response variables. Discussion While self‐reported within this population, not necessarily applicable individuals. demonstrates importance an individualized analysis determining how may impact outcomes MG, implications self‐management.

Язык: Английский

Процитировано

0