Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Фев. 20, 2025

This study aims to compare the difference in serum high-density lipoprotein cholesterol (HDL-C) levels between children with epilepsy and healthy assess its potential influencing factors. For comparison, we retrospectively collected data on 1,002 who visited Department of Neurology at Children's Hospital Nanjing Medical University. Additionally, included 127 underwent routine health examinations our hospital's Health Examination Center. also incorporated 98 recently diagnosed patients had not yet received treatment anti-seizure medications (ASMs) as a source baseline data. Demographic information laboratory test results were retrieved from hospital system. The Kolmogorov-Smirnov test, Mann-Whitney Fisher's exact odds ratios (OR), Spearman or Pearson correlation coefficients, post-hoc analysis used conduct statistical analysis. Healthy exhibited significantly higher HDL-C compared values. Notably, percentage low (<1.0 mmol/L) children, showing an increased risk dyslipidemia (OR, 2.773; 95% CI, 0.9879-7.457). type ASMs notable effect levels, particularly hepatic enzyme-inducing like oxcarbazepine, which raised levels. associated factors such age, history, brain magnetic resonance imaging findings. there was weak negative association vitamin D (R = -0.37, p 0.0014). Moreover, supplementation demonstrated level than those without supplementation. Serum are notably lower children. Treatment can partially increase potentially approaching found Therefore, decrease irrespective receiving should warrant ongoing attention.

Язык: Английский