Citronellal Exerts Sedative‐Like Effects and Augments Diazepam's Action in Swiss Mice, Possibly Through the GABAergic Pathway DOI Creative Commons
Muhammad Torequl Islam, Md. Sakib Al Hasan,

Emon Mia

и другие.

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

ABSTRACT Introduction Citronellal (CTL), a monoterpenoid, exhibits notable neurological activity, including anxiolytic, and anticonvulsant effects, primarily through GABAergic pathways. Our current study aimed to explore CTL's sedative potential using in vitro, vivo, silico approaches the pathway. Methods The vitro activity of CTL was assessed via colorimetric assay, while acute toxicity evaluated Swiss mice per OECD guidelines with doses up 2000 mg/kg establish safety margins. Sedative effects were thiopental sodium (TS, 40 mg/kg)‐induced sleep protocols. administered at 62.5, 125, 250 doses, alone or combined diazepam (DZP, 2 mg/kg) flumazenil (FLU, 0.1 mg/kg). studies also performed GABA A receptors (α1 β2 subunits) investigate possible molecular mechanism. Results results demonstrated that exhibited significantly concentration‐dependent activity. Acute tests indicated high margin (no behavioral physiological abnormalities dose). Additionally, ( p < 0.05) dose‐dependently reduced latency augmented duration animals, compared control group. It decreased increased DZP‐2 reducing this parameter FLU‐0.1. In studies, binding affinities (BAs) receptor –5.6 kcal/mol. Conclusion potent strong profile interaction subunits).

Язык: Английский

Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies DOI
Muhammad Torequl Islam, Md. Sakib Al Hasan, Jannatul Ferdous

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

1
Citronellal Exerts Sedative‐Like Effects and Augments Diazepam's Action in Swiss Mice, Possibly Through the GABAergic Pathway DOI Creative Commons
Muhammad Torequl Islam, Md. Sakib Al Hasan,

Emon Mia

и другие.

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

ABSTRACT Introduction Citronellal (CTL), a monoterpenoid, exhibits notable neurological activity, including anxiolytic, and anticonvulsant effects, primarily through GABAergic pathways. Our current study aimed to explore CTL's sedative potential using in vitro, vivo, silico approaches the pathway. Methods The vitro activity of CTL was assessed via colorimetric assay, while acute toxicity evaluated Swiss mice per OECD guidelines with doses up 2000 mg/kg establish safety margins. Sedative effects were thiopental sodium (TS, 40 mg/kg)‐induced sleep protocols. administered at 62.5, 125, 250 doses, alone or combined diazepam (DZP, 2 mg/kg) flumazenil (FLU, 0.1 mg/kg). studies also performed GABA A receptors (α1 β2 subunits) investigate possible molecular mechanism. Results results demonstrated that exhibited significantly concentration‐dependent activity. Acute tests indicated high margin (no behavioral physiological abnormalities dose). Additionally, ( p < 0.05) dose‐dependently reduced latency augmented duration animals, compared control group. It decreased increased DZP‐2 reducing this parameter FLU‐0.1. In studies, binding affinities (BAs) receptor –5.6 kcal/mol. Conclusion potent strong profile interaction subunits).

Язык: Английский

Процитировано

0