Metabolism and Modification of Apolipoprotein B-Containing Lipoproteins Involved in Dyslipidemia and Atherosclerosis

Biological and Pharmaceutical Bulletin, Год журнала: 2015, Номер 39(1), С. 1 - 24

Опубликована: Дек. 31, 2015

Increased levels of apolipoprotein B (apoB)-containing lipoproteins, such as low density lipoproteins (LDL) and chylomicron remnants, are associated with the development atherosclerosis. Chylomicrons containing apoB-48 secreted from intestine during postprandial state, whereas very (VLDL) apoB-100 constitutively formed in liver. Chylomicron remnants VLDL produced by lipoprotein lipase-mediated lipolysis triglycerides, which is activated C-II bound on particle surfaces. The hepatic uptake these facilitated E (apoE), but inhibited apolipoproteins C-I, C-III. In plasma, further converted into LDL hydrolysis triglycerides. ApoB-100 responsible for LDL. receptor, receptor-related protein heparan sulfate proteoglycans involved clearance and/or apoE. subendothelial retention modification apoB-containing crucial events initiation subendothelium, modified macrophages leads to formation foam cells storing excess amounts cholesteryl esters subsequently apoptosis. This review describes current knowledge about metabolism dyslipidemia atherogenesis. particular, I focus effects apolipoproteins, lipid composition size roles cholesterol, sphingomyelinase apoB denaturation macrophage cell A detailed understanding mechanisms will help develop new therapeutic strategies.

Язык: Английский

---

Postprandial lipoproteins and the molecular regulation of vascular homeostasis

Progress in Lipid Research, Год журнала: 2013, Номер 52(4), С. 446 - 464

Опубликована: Июнь 15, 2013

Язык: Английский

---

Postprandial hyperlipidemia as a potential residual risk factor

Journal of Cardiology, Год журнала: 2015, Номер 67(4), С. 335 - 339

Опубликована: Дек. 29, 2015

Язык: Английский

---

Triglyceride and Triglyceride-Rich Lipoproteins in Atherosclerosis

Frontiers in Molecular Biosciences, Год журнала: 2022, Номер 9

Опубликована: Май 25, 2022

Cardiovascular disease (CVD) is still the leading cause of death globally, and atherosclerosis main pathological basis CVDs. Low-density lipoprotein cholesterol (LDL-C) a strong causal factor atherosclerosis. However, first-line lipid-lowering drugs, statins, only reduce approximately 30% CVD risk. Of note, atherosclerotic (ASCVD) cannot be eliminated in great number patients even their LDL-C levels meet recommended clinical goals. Previously, whether elevated plasma level triglyceride causally associated with ASCVD has been controversial. Recent genetic epidemiological studies have demonstrated that triglyceride-rich (TGRL) are risk factors residual ASCVD. TGRLs metabolites can promote via modulating inflammation, oxidative stress, formation foam cells. In this article, we will make short review TG TGRL metabolism, display evidence association between ASCVD, summarize atherogenic metabolites, discuss current findings advances TG-lowering therapies. This provides information useful for researchers field as well pharmacologists clinicians.

Язык: Английский

---

Lipolysis of triglyceride-rich lipoproteins, vascular inflammation, and atherosclerosis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Год журнала: 2011, Номер 1821(5), С. 858 - 866

Опубликована: Окт. 14, 2011

Язык: Английский

---

Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases

International Journal of Vascular Medicine, Год журнала: 2011, Номер 2012, С. 1 - 11

Опубликована: Сен. 25, 2011

Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated atherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the syndrome and, diabetes. Remnant become attached to wall, where they can penetrate intact endothelium causing foam cell formation. activate circulating leukocytes, upregulate expression endothelial adhesion molecules, facilitate migration inflammatory cells into subendothelial space, complement system. Since humans are postprandial most day, continuous generation remnants after each meal may be one triggers for development atherosclerosis. Modulation lipemia by lifestyle changes pharmacological interventions could result in further decrease cardiovascular mortality morbidity. This paper will provide an update on current concepts concerning relationship between lipemia, inflammation, function, therapeutic options.

Язык: Английский

---

Oxidative stress biomarkers in type 2 diabetes mellitus for assessment of cardiovascular disease risk

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2017, Номер 12(3), С. 455 - 462

Опубликована: Дек. 30, 2017

Язык: Английский

---

Postprandial Dysmetabolism and Oxidative Stress in Type 2 Diabetes: Pathogenetic Mechanisms and Therapeutic Strategies

Medicinal Research Reviews, Год журнала: 2015, Номер 35(5), С. 968 - 1031

Опубликована: Май 6, 2015

Abstract Postprandial dysmetabolism in type 2 diabetes (T2D) is known to impact the progression and evolution of this complex disease process. However, underlying pathogenetic mechanisms still require full elucidation provide guidance for prevention treatment. This review focuses on marked redox changes inflammatory stimuli provoked by spike blood glucose lipids T2D individuals after meals. All causes exacerbated postprandial oxidative stress were analyzed, also considering consequence enhanced inflammation vascular damage. Based in‐depth analysis, current strategies pharmacologic management critically reexamined with particular emphasis their potential redox‐related rationale.

Язык: Английский

---

Postprandial Inflammation: Targeting Glucose and Lipids

Advances in experimental medicine and biology, Год журнала: 2014, Номер unknown, С. 161 - 170

Опубликована: Янв. 1, 2014

Язык: Английский

---

The Fatty Acid Composition of Virgin Olive Oil from Different Cultivars Is Determinant for Foam Cell Formation by Macrophages

Journal of Agricultural and Food Chemistry, Год журнала: 2015, Номер 63(30), С. 6731 - 6738

Опубликована: Июль 17, 2015

Although the beneficial role of Extra Virgin Olive Oil (EVOO) in Mediterranean diet is well-known, its effects on health cannot be attributed solely to oleic acid. In addition minor components, presence other fatty acids (FA), which depend largely cultivar among factors, needs considered. The present study examined effect chylomicron remnant-like particles (CRLP) enriched EVOO from 'Chetoui', 'Buidiego', 'Galega', 'Blanqueta', and 'Picual' cultivars foam cell formation by THP-1 macrophages. cells were incubated with EVOO-CRLP for 24 h. Lipid accumulation was measured determining intracellular total triacylglycerol (TAG) concentration FA composition. Intracellular TAG concentrations higher 'Chetoui' 'Blanqueta' CRLP (0.33 ± 0.05 0.38 0.07 μmol/mg protein, respectively) than 'Buidiego' (0.20 0.24 0.06 respectively). conclusion, linoleic acid-rich induced incorporation into macrophages compared EVOO, 18:1/18:2 ratio being consistently correlated accumulation. results this demonstrated that differences EVOO-FA composition may have an important formation.

Язык: Английский

---