Achieving
synchronization
between
the
central
and
peripheral
body
clocks
is
essential
for
ensuring
optimal
metabolic
function.
Meal
timing
an
emerging
field
of
research
that
investigates
influence
eating
patterns
on
our
circadian
rhythm,
metabolism,
overall
health.
This
narrative
review
examines
relationship
meal
timing,
clock
genes,
hormones,
It
analyzes
existing
literature
experimental
data
to
explore
connection
mealtime,
rhythms,
processes.
The
available
evidence
highlights
importance
aligning
mealtime
with
body’s
natural
rhythms
promote
health
prevent
disorders.
Specifically,
studies
show
consuming
meals
later
in
day
associated
a
elevated
prevalence
disorders,
while
early
time-restricted
eating,
such
as
having
breakfast
earlier
dinner,
improves
levels
glucose
blood
substrate
oxidation.
Circadian
including
cortisol
melatonin,
interact
mealtimes
play
vital
roles
regulating
Cortisol,
aligned
dawn
diurnal
mammals,
activates
energy
reserves,
stimulates
appetite,
influences
gene
expression,
synchronizes
clocks.
Consuming
during
periods
melatonin
levels,
specifically
night,
has
been
correlated
potential
implications
tolerance.
Understanding
mechanisms
synchronization,
genetics,
interactions
chronotype,
sleep
duration,
hormonal
changes,
provides
valuable
insights
optimizing
dietary
strategies
timing.
knowledge
contributes
improved
well-being
by
rhythm.
Nutrients,
Год журнала:
2025,
Номер
17(3), С. 529 - 529
Опубликована: Янв. 31, 2025
Fasting-feeding
timing
is
a
crucial
pattern
implicated
in
the
regulation
of
daily
circadian
rhythms.
The
interplay
between
sleep
and
meal
underscores
importance
maintaining
alignment
order
to
avoid
creating
metabolic
environment
conducive
carcinogenesis
following
molecular
systemic
disruption
performance
immune
function.
chronicity
such
condition
may
support
initiation
progression
cancer
through
variety
mechanisms,
including
increased
oxidative
stress,
suppression,
activation
proliferative
signaling
pathways.
This
review
aims
summarize
current
evidence
from
human
studies
provide
an
overview
potential
mechanisms
underscoring
role
chrononutrition
(including
time-restricted
eating)
on
risk.
Current
shows
that
morning
chronotype,
suggesting
physiological
rhythms
eating
timing,
associated
with
lower
risk
cancer.
Also,
early
prolonged
nighttime
fasting
were
also
suggests
chronotype
influences
cell
cycle
regulation,
modulation
pathways
inflammation,
gut
microbiota
fluctuations.
In
conclusion,
although
there
are
no
clear
guidelines
this
matter,
emerging
supports
hypothesis
time-related
(i.e.,
time/calorie-restricted
feeding
intermittent/periodic
fasting)
could
potentially
lead
reduced
Clocks & Sleep,
Год журнала:
2023,
Номер
5(3), С. 507 - 535
Опубликована: Сен. 6, 2023
Achieving
synchronization
between
the
central
and
peripheral
body
clocks
is
essential
for
ensuring
optimal
metabolic
function.
Meal
timing
an
emerging
field
of
research
that
investigates
influence
eating
patterns
on
our
circadian
rhythm,
metabolism,
overall
health.
This
narrative
review
examines
relationship
meal
timing,
clock
genes,
hormones,
It
analyzes
existing
literature
experimental
data
to
explore
connection
mealtime,
rhythms,
processes.
The
available
evidence
highlights
importance
aligning
mealtime
with
body’s
natural
rhythms
promote
health
prevent
disorders.
Specifically,
studies
show
consuming
meals
later
in
day
associated
elevated
prevalence
disorders,
while
early
time-restricted
eating,
such
as
having
breakfast
earlier
dinner,
improves
levels
glucose
blood
substrate
oxidation.
Circadian
including
cortisol
melatonin,
interact
mealtimes
play
vital
roles
regulating
Cortisol,
aligned
dawn
diurnal
mammals,
activates
energy
reserves,
stimulates
appetite,
influences
gene
expression,
synchronizes
clocks.
Consuming
during
periods
melatonin
levels,
specifically
night,
has
been
correlated
potential
implications
tolerance.
Understanding
mechanisms
synchronization,
genetics,
interactions
chronotype,
sleep
duration,
hormonal
changes,
provides
valuable
insights
optimizing
dietary
strategies
timing.
knowledge
contributes
improved
well-being
by
rhythm.
Journal of Personalized Medicine,
Год журнала:
2024,
Номер
14(4), С. 391 - 391
Опубликована: Апрель 6, 2024
The
prevalence
of
schizophrenia,
affecting
approximately
1%
the
global
population,
underscores
urgency
for
innovative
therapeutic
strategies.
Recent
insights
into
role
neuroinflammation,
gut–brain
axis,
and
microbiota
in
schizophrenia
pathogenesis
have
paved
way
exploration
psychobiotics
as
a
novel
treatment
avenue.
These
interventions,
targeting
gut
microbiome,
offer
promising
approach
to
ameliorating
psychiatric
symptoms.
Furthermore,
advancements
artificial
intelligence
nanotechnology
are
set
revolutionize
psychobiotic
development
application,
enhance
their
production,
precision,
effectiveness.
This
interdisciplinary
heralds
new
era
management,
potentially
transforming
patient
outcomes
offering
beacon
hope
those
afflicted
by
this
complex
disorder.
Nutrients,
Год журнала:
2024,
Номер
16(14), С. 2259 - 2259
Опубликована: Июль 13, 2024
Dietary
components,
including
dietary
fiber,
unsaturated
fatty
acids,
and
polyphenols,
along
with
meal
timing
spacing,
significantly
affect
the
microbiota’s
capacity
to
produce
various
metabolites
essential
for
quality
sleep
overall
health.
This
review
explores
role
of
gut
microbiota
in
regulating
through
such
as
short-chain
tryptophan,
serotonin,
melatonin,
gamma-aminobutyric
acid.
A
balanced
diet
rich
plant-based
foods
enhances
production
these
sleep-regulating
metabolites,
potentially
benefiting
aims
investigate
how
habits
composition,
it
produces,
subsequent
impact
on
related
health
conditions.
Life,
Год журнала:
2024,
Номер
14(10), С. 1234 - 1234
Опубликована: Сен. 26, 2024
Microbes
have
inhabited
the
earth
for
hundreds
of
millions
years
longer
than
humans.
The
microbiota-gut-brain
axis
(MGBA)
represents
a
bidirectional
communication
pathway.
These
communications
occur
between
central
nervous
system
(CNS),
enteric
(ENS),
and
emotional
cognitive
centres
brain.
field
research
on
gut-brain
has
grown
significantly
during
past
two
decades.
Signalling
occurs
gut
microbiota
brain
through
neural,
endocrine,
immune,
humoral
pathways.
A
substantial
body
evidence
indicates
that
MGBA
plays
pivotal
role
in
various
neurological
diseases.
include
Alzheimer's
disease
(AD),
autism
spectrum
disorder
(ASD),
Rett
syndrome,
attention
deficit
hyperactivity
(ADHD),
non-Alzheimer's
neurodegeneration
dementias,
fronto-temporal
lobe
dementia
(FTLD),
Wilson-Konovalov
(WD),
multisystem
atrophy
(MSA),
Huntington's
chorea
(HC),
Parkinson's
(PD),
multiple
sclerosis
(MS),
amyotrophic
lateral
(ALS),
temporal
epilepsy
(TLE),
depression,
schizophrenia
(SCZ).
Furthermore,
correlation
therapeutics
will
be
discussed.
Conversely,
mood
delivery,
exercise,
psychotropic
agents,
stress,
neurologic
drugs
can
influence
MGBA.
By
understanding
MGBA,
it
may
possible
to
facilitate
into
microbial-based
interventions
therapeutic
strategies
Nutrients,
Год журнала:
2024,
Номер
16(2), С. 182 - 182
Опубликована: Янв. 5, 2024
Fibromyalgia
(FM)
is
often
accompanied
by
chronic
fatigue
syndrome
(CFS).
It
a
poorly
understood
disorder
that
mainly
affects
women
and
leads
to
pain,
fatigue,
insomnia,
among
other
symptoms,
which
decrease
quality
of
life.
Due
the
inefficiency
current
pharmacological
treatments,
increasing
interest
being
directed
towards
non-pharmacological
multicomponent
therapies.
However,
nutrition
chronobiology
are
overlooked
when
developing
This
narrative
critical
review
explore
relevance
nutritional
chronobiological
strategies
in
therapeutic
management
FM
often-associated
CFS.
Reviewed
literature
offers
scientific
evidence
for
association
dietary
habits,
nutrient
levels,
body
composition,
gut
microbiota
imbalance,
alterations,
their
interrelation
with
development
severity
symptoms.
highlights
key
role
as
relevant
indispensable
components
multidisciplinary
approach
Frontiers in Physiology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 29, 2024
Background
Circadian
rhythms
are
reported
to
influence
physiological
processes
in
the
gastrointestinal
system,
but
associations
between
circadian
syndrome
(Circs)
and
chronic
diarrhea
(CD)
remain
unclear.
Here,
we
explored
such
relationships
provide
new
insights
into
CD
management.
Methods
We
conducted
a
cross-sectional
retrospective
analysis
using
National
Health
Nutrition
Examination
Survey
(NHANES)
data
2005
2010.
Univariate
multivariable
logistic
regression
analyses
were
performed
on
weighted
explore
Circs
CD.
Results
presented
forest
plots,
odds
ratios
(ORs),
95%
confidence
intervals
(CIs).
Data
with
p
-values
<
0.05
considered
statistically
significant.
In
total,
5,661
US
participants,
of
which
412
had
(weighted
percentage
=
6.20%),
enrolled.
univariate
analyses,
participants
significantly
higher
risk
(OR
1.51,
CI:
1.15–1.99).
After
adjusting
for
covariates,
model
2
1.40,
1.03–1.90)
3
1.42,
1.01–2.00)
consistent
1
data.
Additionally,
number
components
was
positively
associated
all
three
models.
Subgroup
revealed
an
association
who
high
blood
pressure
2.46,
1.48–4.11,
0.001).
Conclusion
this
study,
found
that
is
adults,
especially
those
pressure.
This
may
management
strategies
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 16, 2025
The
complex
interaction
between
circadian
rhythms
and
physiological
functions
is
essential
for
maintaining
human
health.
At
the
heart
of
this
lies
PERIOD
proteins
(PERs),
pivotal
to
clock,
influencing
timing
behavioral
processes
impacting
oxidative
stress,
immune
functionality,
tumorigenesis.
PER1
orchestrates
cooperation
enzyme
GPX1,
modulating
mitochondrial
dynamics
in
sync
with
daily
thus
regulating
mechanisms
managing
energy
substrates.
PERs
innate
cells
modulate
temporal
patterns
NF-κB
TNF-α
activities,
as
well
response
LPS-induced
toxic
shock,
initiating
inflammatory
responses
that
escalate
into
chronic
conditions.
Crucially,
cancer
cell
behaviors
including
proliferation,
apoptosis,
migration
by
levels
cycle
stimulating
expression
oncogenes
c-Myc
MDM2.
PER2/3,
antagonists
stem
biology,
play
important
roles
differentiating
their
stemness.
Importantly,
Pers
serve
a
significant
factor
early
diagnosis
prognosis.
This
review
delves
link
rhythm
regulator
PERs,
disruptions
rhythm,
oncogenesis.
We
examine
evidence
highlights
how
dysfunctions
activities
initiate
development,
aid
tumor
growth,
modify
metabolism
through
pathways
involved
stress
system.
Comprehending
these
connections
opens
new
development
rhythm-based
therapeutic
strategies,
aims
boosting
enhancing
treatments.
