Coffee leaf polyphenol-rich extracts alleviated lipopolysaccharide-induced intestinal barrier dysfunction: Insights from a Caco-2/U937 co-culture model

Food Bioscience, Год журнала: 2024, Номер 61, С. 104639 - 104639

Опубликована: Июнь 27, 2024

Язык: Английский

Nutrigenomic underpinnings of intestinal stem cells in inflammatory bowel disease and colorectal cancer development

Frontiers in Genetics, Год журнала: 2024, Номер 15

Опубликована: Авг. 30, 2024

Food-gene interaction has been identified as a leading risk factor for inflammatory bowel disease (IBD) and colorectal cancer (CRC). Accordingly, nutrigenomics emerges new approach to identify biomarkers therapeutic targets these two strongly associated gastrointestinal diseases. Recent studies in stem cell biology have further shown that diet nutrition signal intestinal cells (ISC) by altering nutrient-sensing transcriptional activities, thereby influencing barrier integrity susceptibility inflammation tumorigenesis. This review recognizes the dietary factors related both CRC IBD investigates their impact on overlapping transcription governing activities homeostasis post-injury responses. Our objective is provide framework study food-gene regulatory network of disease-contributing inspire nutrigenomic approaches detecting treating diet-related CRC.

Язык: Английский

Protective Capacity of Helichrysum italicum Infusion Against Intestinal Barrier Disruption and Translocation of Salmonella Infantis

Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1398 - 1398

Опубликована: Окт. 19, 2024

is a Mediterranean plant with well-known anti-inflammatory activity, but our previous whole transcriptome analysis has found that

Язык: Английский