Introduction to Polycystic Ovary Syndrome (PCOS) and Nutritional Challenges

Опубликована: Янв. 1, 2025

Язык: Английский

---

A bacterial cellulose/polyvinyl alcohol/nitro graphene oxide double layer network hydrogel efficiency antibacterial and promotes wound healing

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 131957 - 131957

Опубликована: Апрель 29, 2024

Язык: Английский

---

Effects of social media influencer credibility on their followers’ dietary supplement evaluations and purchase intentions

Journal of Marketing Communications, Год журнала: 2025, Номер unknown, С. 1 - 24

Опубликована: Фев. 6, 2025

Язык: Английский

---

Critical Review on Orally Administered Nutricosmetics: Food-Based Solutions Conferring Skin Health from the inside out

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 104946 - 104946

Опубликована: Фев. 1, 2025

Язык: Английский

---

A prospective multicenter phase III clinical trial evaluating the efficacy and safety of silk elastin sponge in patients with skin defects

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 2, 2025

Silk elastin sponge, a novel recombinant protein used for wound healing, has been shown to be effective in promoting macrophage migration, epithelial growth, granulation, and angiogenesis both preclinical (in vitro vivo) clinical studies. This study aimed evaluate the efficacy safety of silk sponges treatment chronic acute wounds. A prospective multicenter, single-arm, uncontrolled trial included 20 patients with wounds five wounds, applying sponge after debridement. The primary endpoints were percentage well-prepared beds 14 days treatment. procedure was also assessed. results showed that 90.0% had by day 14, 24 out 25 completed treatment, one case discontinued due local infection. concluded may an new option are unresponsive existing treatments.Trial registration: jRCT2052210072. Registered on 11 July 2023 Japan Registry Clinical Trials ( http://jrct.niph.go.jp ).

Язык: Английский

---

Cytotoxicity and Multi-Enzyme Inhibition of Nepenthes miranda Stem Extract on H838 Human Non-Small Cell Lung Cancer Cells and RPA32, Elastase, Tyrosinase, and Hyaluronidase Proteins

Plants, Год журнала: 2024, Номер 13(6), С. 797 - 797

Опубликована: Март 11, 2024

The carnivorous pitcher plants of the genus Nepenthes have long been known for their ethnobotanical applications. In this study, we prepared various extracts from pitcher, stem, and leaf miranda using 100% ethanol assessed inhibitory effects on key enzymes related to skin aging, including elastase, tyrosinase, hyaluronidase. cytotoxicity stem extract N. H838 human lung carcinoma cells were also characterized by cell survival, migration, proliferation, apoptosis induction, DNA damage. cytotoxic efficacy was enhanced when combined with chemotherapeutic agent 5-fluorouracil (5-FU), indicating a synergistic effect. Flow cytometry analysis suggested that might suppress proliferation inducing G2 cycle arrest, thereby inhibiting proliferation. Gas chromatography–mass spectrometry (GC–MS) enabled tentative identification 15 most abundant compounds in miranda. Notably, showed potent inhibition RPA32 protein (huRPA32), critical replication, suggesting novel mechanism its anticancer action. Molecular docking studies further substantiated interaction between huRPA32, highlighting bioactive compounds, especially two constituents, stigmast-5-en-3-ol plumbagin, as potential inhibitors huRPA32’s DNA-binding activity, offering promising avenues cancer therapy. Overall, our findings position source natural therapeutics anti-skin-aging treatments, warranting investigation into molecular mechanisms clinical

Язык: Английский

---

Wearable Solid-Phase Microextraction Sampling for Enhanced Detection of Volatile Analytes in Human Ears

Analytica Chimica Acta, Год журнала: 2024, Номер 1318, С. 342923 - 342923

Опубликована: Июль 2, 2024

Язык: Английский

---

Garcinia flavonoids for healthy aging: Anti-senescence mechanisms and cosmeceutical applications in skin care

Fitoterapia, Год журнала: 2024, Номер 180, С. 106282 - 106282

Опубликована: Ноя. 1, 2024

Язык: Английский

---

Skin Aging and the Upcoming Role of Ferroptosis in Geroscience

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8238 - 8238

Опубликована: Июль 28, 2024

The skin is considered the most important organ system in mammals, and as population ages, it to consider aging anti-aging therapeutic strategies. Exposure of various insults induces significant changes throughout our lives, differentiating a young adult from that an older adult. These are caused by combination intrinsic extrinsic aging. We report interactions between its metabolism, showing network due several factors. For example, iron nutrient for humans, but level increases with aging, inducing deleterious effects on cellular functions. Recently, was discovered ferroptosis, or iron-dependent cell death, linked diseases. pursuit new molecular targets ferroptosis has recently attracted attention. Prevention effective strategy treatment diseases, especially old age. However, pathological biological mechanisms underlying still not fully understood, diseases such melanoma autoimmune Only few basic studies regulated death exist, challenge turn into clinical applications.

Язык: Английский

---

Unveiling the Nutritional Treasure Trove: A Comparative Analysis of Two Azolla Species for Potential Food Applications

Food and Humanity, Год журнала: 2024, Номер 3, С. 100444 - 100444

Опубликована: Ноя. 2, 2024

Язык: Английский

---