The Effects and Mechanisms of n-3 and n-6 Polyunsaturated Fatty Acids in the Central Nervous System

Cellular and Molecular Neurobiology, Год журнала: 2025, Номер 45(1)

Опубликована: Март 17, 2025

The brain is rich in fatty acids (FAs), with polyunsaturated (PUFAs), such as docosahexaenoic acid (C22:6n-3, DHA) and arachidonic (C20:4n-6, ARA), the former predominantly stored form of phosphatidylcholine, phosphatidyl ethanolamine (PE, diacyl plasma phospholipid proform), phosphatidylserine (PS), while latter mainly found phosphoglycerides (EPG) contributes to constitute most phosphoglycerides. When required by body, PUFAs are liberated from membrane phospholipids (either directly or via their metabolites, which generated a series enzymatic reactions) participate various cerebral physiological processes. derivatives play crucial roles modulating numerous bodily functions, including neuronal signal transmission, neurogenesis, neuroinflammation, glucose uptake brain, thereby sustaining fundamental function. Although have been implicated spectrum neurological disorders, acute injury (TBI), multiple sclerosis (MS), neurodegenerative diseases, role conditions depression, Alzheimer's disease (AD), Parkinson's (PD) particularly noteworthy. These disorders closely linked critical cognition, memory, inflammatory Given substantial body research elucidating involvement pathogenesis progression these this review will specifically concentrate on impact within contexts.

Язык: Английский

Fatty acid metabolism in the placentae of Gestational Diabetes Mellitus

Prostaglandins Leukotrienes and Essential Fatty Acids, Год журнала: 2025, Номер unknown, С. 102682 - 102682

Опубликована: Апрель 1, 2025

Язык: Английский