The Omicron Strain of the SARS-CoV-2 Coronavirus and Its Variants DOI Creative Commons

Sergey G. Sсherbak,

Dmitry A. Vologzhanin, Aleksandr S. Golota

и другие.

Journal of clinical practice, Год журнала: 2023, Номер 14(3), С. 50 - 68

Опубликована: Окт. 19, 2023

The SARS-CoV-2 coronavirus has been circulating among the world population for 3 years, infecting hundreds of millions people. Numerous reports from all over indicate that majority infections are caused by Omicron variant and its subvariants, which predominate previously emerged variants. genome strain accumulated dozens mutations increase viruss adaptability cause emergence new variants subvariants with increased contagiousness, transmissibility, ability to evade immune response. This compromises protection provided vaccines or humoral immunity induced previous infections. Although biology is well understood, infect, replicate, spread in a depends on specific context during different periods pandemic. It assumed arise as result chronic infection immunocompromised individuals. intralineage recombination an opportunity virus gain phenotypic advantages distantly related last variant, named Kraken due unprecedentedly high descendant recombinant line. constantly evolving direction evading neutralization vaccines, therefore, constant work underway develop new, more effective other antiviral agents.

Язык: Английский

COVID-19 annual update: a narrative review DOI Creative Commons
Michela Biancolella, Vito Luigi Colona, Lucio Luzzatto

и другие.

Human Genomics, Год журнала: 2023, Номер 17(1)

Опубликована: Июль 24, 2023

Abstract Three and a half years after the pandemic outbreak, now that WHO has formally declared emergency is over, COVID-19 still significant global issue. Here, we focus on recent developments in genetic genomic research COVID-19, give an outlook state-of-the-art therapeutical approaches, as gradually transitioning to endemic situation. The sequencing characterization of rare alleles different populations made it possible identify numerous genes affect either susceptibility or severity disease. These findings provide beginning new avenues pan-ethnic therapeutic well potential screening protocols. causative virus, SARS-CoV-2, spotlight, but novel threatening virus could appear anywhere at any time. Therefore, continued vigilance further warranted. We also note emphatically prevent future pandemics other world-wide health crises, imperative capitalize what have learnt from COVID-19: specifically, regarding its origins, world’s response, insufficient preparedness. This requires unprecedented international collaboration timely data sharing for coordination effective response rapid implementation containment measures.

Язык: Английский

Процитировано

28
Recent SARS-CoV-2 evolution trajectories indicate the emergence of Omicron’s several subvariants and the current rise of KP.3.1.1 and XEC DOI
Chiranjib Chakraborty, Manojit Bhattacharya, Ali S. Abdelhameed

и другие.

Virology, Год журнала: 2025, Номер unknown, С. 110508 - 110508

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Immunogenicity and protection efficacy of a COVID-19 DNA vaccine encoding spike protein with D614G mutation and optimization of large-scale DNA vaccine production DOI Creative Commons
Aytül Gül, Sedef Erkunt Alak, Hüseyin Can

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 15, 2024

Abstract Severe acute respiratory syndrome coronavirus 2 had devastating consequences for human health. Despite the introduction of several vaccines, COVID-19 continues to pose a serious health risk due emerging variants concern. DNA vaccines gained importance during pandemic their advantages such as induction both arms immune response, rapid development, stability, and safety profiles. Here, we report immunogenicity protective efficacy vaccine encoding spike protein with D614G mutation (named pcoSpikeD614G) define large-scale production process. According in vitro studies, pcoSpikeD614G expressed abundant HEK293T cells. After administration BALB/c mice through intramuscular (IM) route intradermal using an electroporation device (ID + EP), it induced high level anti-S1 IgG neutralizing antibodies ( P < 0.0001), strong Th1-biased response shown by IgG2a polarization 0.01), increase IFN-γ levels increment ratio secreting CD4 (3.78–10.19%) CD8 (5.24–12.51%) T Challenging K18-hACE2 transgenic showed that administered IM ID EP routes conferred 90–100% protection there was no sign pneumonia. Subsequently, evaluated promising candidate scale-up studies were performed. Accordingly, process described, including 36 h fermentation E. coli DH5α cells containing resulting wet cell weight 242 g/L three-step chromatography purification vaccine.

Язык: Английский

Процитировано

2
Mechanistic study of the transmission pattern of the SARS‐CoV‐2 omicron variant DOI Creative Commons
Ke An,

Xianzhi Yang,

Mengqi Luo

и другие.

Proteins Structure Function and Bioinformatics, Год журнала: 2024, Номер 92(6), С. 705 - 719

Опубликована: Янв. 5, 2024

Abstract The omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) characterized by 30 mutations in its spike protein, has rapidly spread worldwide since November 2021, significantly exacerbating the ongoing COVID‐19 pandemic. In order to investigate relationship between these and variant's high transmissibility, we conducted a systematic analysis mutational effect on spike–angiotensin‐converting enzyme‐2 (ACE2) interactions explored structural/energy correlation key mutations, utilizing reliable coarse‐grained model. Our study extended beyond receptor‐binding domain (RBD) trimer through comprehensive modeling full‐length rather than just RBD. free‐energy calculation revealed that enhanced binding affinity protein ACE2 receptor is correlated with increased structural stability isolated thus explaining heightened transmissibility. conclusion was supported our experimental analyses involving expression purification trimer. Furthermore, energy decomposition established those electrostatic make major contributions this effect. We categorized into four groups an analytical framework can be employed studying future mutations. Additionally, calculations rationalized reduced towards most available therapeutic neutralizing antibodies, when compared wild type. By providing concrete data offering solid explanation, contributes better understanding theories observations lays foundation for investigations.

Язык: Английский

Процитировано

1
Co-administration of recombinant BCG and SARS-CoV-2 proteins leads to robust antiviral immunity DOI
Mario A. Ramírez, Ricardo A. Loaiza,

Yohana Martínez-Balboa

и другие.

Vaccine, Год журнала: 2024, Номер 42(23), С. 126203 - 126203

Опубликована: Авг. 22, 2024

Язык: Английский

Процитировано

1
Modelling the Relative Vaccine Efficacy of ARCT-154, a Self-Amplifying mRNA COVID-19 Vaccine, versus BNT162b2 Using Immunogenicity Data DOI Creative Commons
Văn Hùng Nguyễn, Pascal Crépey,

Jean Marie Pivette

и другие.

Vaccines, Год журнала: 2024, Номер 12(10), С. 1161 - 1161

Опубликована: Окт. 11, 2024

Background: Self-amplifying mRNA vaccines have the potential to increase magnitude and duration of protection against COVID-19 by boosting neutralizing antibody titers cellular responses. Methods: In this study, we used immunogenicity data from a phase 3 randomized trial comparing ARCT-154, self-amplifying vaccine, with BNT162b2 vaccine estimate relative efficacy (rVE) two over time in younger (<60 years) older (≥60 adults. Results: By day 181 post-vaccination, rVE symptomatic severe Wuhan-Hu-1 disease was 9.2–11.0% 1.2–1.5%, respectively, across age groups whereas Omicron BA.4/5 26.8–48.0% 5.2–9.3%, groups. Sensitivity analysis showed that varying threshold titer for 50% up 10% convalescent sera revealed incremental benefits ARCT-154 BNT162b2, an 28.0% adults aged ≥60 year. Conclusions: Overall, results study indicate elicits broader more durable SARS-CoV-2, translating enhanced protection, particularly BA.4/5.

Язык: Английский

Процитировано

0
Characterization of the viral genome of Omicron variants of SARS-CoV-2 circulating in Tripura, a remote frontier state in Northeastern India DOI
Ankan Chakrabarti, Saikat Majumder, Apurba Sarkar

и другие.

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Окт. 28, 2024

Язык: Английский

Процитировано

0
The Omicron Strain of the SARS-CoV-2 Coronavirus and Its Variants DOI Creative Commons

Sergey G. Sсherbak,

Dmitry A. Vologzhanin, Aleksandr S. Golota

и другие.

Journal of clinical practice, Год журнала: 2023, Номер 14(3), С. 50 - 68

Опубликована: Окт. 19, 2023

The SARS-CoV-2 coronavirus has been circulating among the world population for 3 years, infecting hundreds of millions people. Numerous reports from all over indicate that majority infections are caused by Omicron variant and its subvariants, which predominate previously emerged variants. genome strain accumulated dozens mutations increase viruss adaptability cause emergence new variants subvariants with increased contagiousness, transmissibility, ability to evade immune response. This compromises protection provided vaccines or humoral immunity induced previous infections. Although biology is well understood, infect, replicate, spread in a depends on specific context during different periods pandemic. It assumed arise as result chronic infection immunocompromised individuals. intralineage recombination an opportunity virus gain phenotypic advantages distantly related last variant, named Kraken due unprecedentedly high descendant recombinant line. constantly evolving direction evading neutralization vaccines, therefore, constant work underway develop new, more effective other antiviral agents.

Язык: Английский

Процитировано

0