Gene therapies for neurogenetic disorders

Trends in Molecular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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A multiverse of BRCA vulnerabilities

Nature Cancer, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Язык: Английский

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Multiple nucleotide variants in genetic diagnosis: implications from 11,467 cases of hearing loss

Journal of genetics and genomics/Journal of Genetics and Genomics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Tissue-specific modulation of CRISPR activity by miRNA-sensing guide RNAs

Nucleic Acids Research, Год журнала: 2025, Номер 53(2)

Опубликована: Янв. 11, 2025

Abstract Nucleic acid nanostructures offer unique opportunities for biomedical applications due to their sequence-programmable structures and functions, which enable the design of complex responses molecular cues. Control biological activity therapeutic cargoes based on endogenous signatures holds potential overcome major hurdles in translational research: cell specificity off-target effects. Endogenous microRNAs (miRNAs) can be used profile type state, are ideal inputs RNA nanodevices. Here, we present CRISPR MiRAGE (miRNA-activated genome editing), a tool comprising dynamic single-guide that senses miRNA complexed with Argonaute proteins controls downstream (Clustered Regularly Interspaced Short Palindromic Repeats) detected signature. We study operation miRNA-sensing attain muscle-specific activation gene editing through models Duchenne muscular dystrophy. By enabling RNA-controlled activity, this technology creates advance tissue-specific treatments human diseases.

Язык: Английский

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Advancing Fish Disease Research through CRISPR-Cas Genome Editing: Recent Developments and Future Perspectives

Fish & Shellfish Immunology, Год журнала: 2025, Номер unknown, С. 110220 - 110220

Опубликована: Фев. 1, 2025

Язык: Английский

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Optimizing HDAC inhibitors to Enhance HDR-associated CRISPR-Cas9 Gene Editing Efficiency In Vivo and In Vitro

Heliyon, Год журнала: 2025, Номер unknown, С. e42971 - e42971

Опубликована: Фев. 1, 2025

Язык: Английский

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Recent advances in biotechnology and bioengineering for efficient microalgal biofuel production

Fuel Processing Technology, Год журнала: 2025, Номер 270, С. 108199 - 108199

Опубликована: Март 4, 2025

Язык: Английский

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Subunit vaccine of PCV3 Capsid protein produced by sf9 cells with double knockout of Caspase-1 and Dronc induces strong immune response in mice

Veterinary Microbiology, Год журнала: 2025, Номер 304, С. 110452 - 110452

Опубликована: Март 4, 2025

Язык: Английский

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is an alternative CRISPR/Cas9 co-conversion marker in

PubMed, Год журнала: 2025, Номер 2025

Опубликована: Янв. 1, 2025

The identification of genome-edited individuals by CRISPR/Cas9 in Caenorhabditis elegans often relies on the introduction a second mutation with visible phenotype. Popular targets for such co-conversion are dpy-10 and sqt-1 , both located chromosome II. In this study, we introduce sqt-3 ( sc63 ) V as an alternative marker to facilitate generation detection genome edits C. . Its location makes desirable when editing Additionally, conserved nature provides potential applicability other nematode species.

Язык: Английский

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Recent advances in CRISPR-Cas system for Saccharomyces cerevisiae engineering

Biotechnology Advances, Год журнала: 2025, Номер 81, С. 108557 - 108557

Опубликована: Март 12, 2025

Язык: Английский

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