siRNA tackles cancer: Immune checkpoint inhibitors and siRNA combinations

Molecular Therapy — Nucleic Acids, Год журнала: 2025, Номер 36(1), С. 102429 - 102429

Опубликована: Янв. 6, 2025

Язык: Английский

Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment

Nanomaterials, Год журнала: 2025, Номер 15(2), С. 122 - 122

Опубликована: Янв. 16, 2025

Nano-oncologic vaccines represent a groundbreaking approach in the field of cancer immunotherapy, leveraging unique advantages nanotechnology to enhance effectiveness and specificity treatments. These utilize nanoscale carriers deliver tumor-associated antigens immunostimulatory adjuvants, facilitating targeted immune activation promoting robust antitumor responses. By improving antigen presentation localizing within tumor microenvironment, nano-oncologic can significantly increase efficacy particularly when combined with other treatment modalities. This review highlights mechanisms through which operate, their potential overcome existing limitations treatment, ongoing advancements design. Additionally, it discusses delivery approach, such as EPR effects, pH response, ultrasonic magnetic response. The combination therapy effects photothermal therapy, radiotherapy, or checkpoint inhibitors are also discussed. Overall, hold great promise for changing landscape advancing personalized medicine, paving way more effective therapeutic strategies tailored individual patient needs.

Язык: Английский

Small interfering RNA: From designing to therapeutic in cancer

Journal of Genetic Engineering and Biotechnology, Год журнала: 2025, Номер 23(2), С. 100484 - 100484

Опубликована: Апрель 4, 2025

Язык: Английский