Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications

Frontiers in Molecular Neuroscience, Год журнала: 2022, Номер 15

Опубликована: Ноя. 9, 2022

Central nervous system (CNS) disease is a general term for series of complex and diverse diseases, including Alzheimer’s (AD), Parkinson’s (PD), multiple sclerosis (MS), CNS tumors, stroke, epilepsy, amyotrophic lateral (ALS). Interneuron neuron-glia cells communicate with each other through their homeostatic microenvironment. Exosomes in the microenvironment have crucial impacts on interneuron by transferring contents, such as proteins, lipids, ncRNAs, constituting novel form cell-to-cell interaction communication. Exosomal noncoding RNAs (ncRNAs), microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), PIWI-interacting (piRNAs), regulate physiological functions maintain homeostasis. are regarded extracellular messengers that transfer ncRNAs between neurons body fluids due to ability cross blood-brain barrier. This review aims summarize current understanding exosomal prospective diagnostic biomarkers, pathological regulators, therapeutic strategies clinical applications. We also provide an all-sided discussion comparison some similar diseases main limitations challenges

Язык: Английский

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The FOXO family of transcription factors: key molecular players in gastric cancer

Journal of Molecular Medicine, Год журнала: 2022, Номер 100(7), С. 997 - 1015

Опубликована: Июнь 10, 2022

Язык: Английский

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FADD as a key molecular player in cancer progression

Molecular Medicine, Год журнала: 2022, Номер 28(1)

Опубликована: Ноя. 8, 2022

Abstract Cancer is a leading disease-related cause of death worldwide. Despite advances in therapeutic interventions, cancer remains major global public health problem. pathogenesis extremely intricate and largely unknown. Fas-associated protein with domain (FADD) was initially identified as an adaptor for receptor-mediated extrinsic apoptosis. Recent evidence suggests that FADD plays vital role non-apoptotic cellular processes, such proliferation, autophagy, necroptosis. expression activity are modulated by complicated network DNA methylation, non-coding RNA, post-translational modification. dysregulation has been shown to be closely associated the numerous types cancer. However, detailed mechanisms involved progression still not fully understood. This review mainly summarizes recent findings on structure, functions, regulatory focuses its progression. The clinical implications biomarker target patients also discussed. information reviewed herein may expand researchers’ understanding contribute development FADD-based strategies patients.

Язык: Английский

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Circular RNA as a Novel Biomarker for Diagnosis and Prognosis and Potential Therapeutic Targets in Multiple Myeloma

Cancers, Год журнала: 2022, Номер 14(7), С. 1700 - 1700

Опубликована: Март 27, 2022

Circular RNAs (circRNAs) are a novel type of covalently closed involved in several physiological and pathological processes. They display tissue-specific expression constant, abundant, highly conserved, making them perfect markers for diagnosis prognosis. Several studies have proposed that circRNAs also differentially produced malignancies where they oncogenic effects. Furthermore, affecting microRNAs modify the profile transcription factors which play essential roles tumors. CircRNAs within hematopoietic compartment were identified as modulators mechanisms able to enhance or suppress tumor progression blood malignancies. Moreover, suggested confer resistance conventional drugs employed cancers. In this review, we highlight growing role controlling by multiple myeloma genesis. We propose can be considered potential diagnostic prognostic markers, induce chemoresistance, might represent therapeutic targets myeloma.

Язык: Английский

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Recent advances of nucleic acid-based cancer biomarkers and biosensors

Coordination Chemistry Reviews, Год журнала: 2023, Номер 497, С. 215456 - 215456

Опубликована: Сен. 26, 2023

Язык: Английский

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