Journal of Porous Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 20, 2024
Язык: Английский
Therapeutic Delivery, Год журнала: 2023, Номер 14(9), С. 595 - 613
Опубликована: Сен. 1, 2023
Cancer disease is one of the most frequent life-threatening, with a high fatality rate worldwide. However, recent immunotherapy studies in various tumours have yielded unsatisfactory outcomes, just few individuals experiencing long-term responses. To overcome these issues, nowadays internal stimuli-responsive nanocarriers been widely exploited to transport wide range active substances, including peptides, genes and medicines. These nanosystems could be chemically adjusted produce target-based drug release at target location, minimizing pathological physiological difficulties while increasing therapeutic efficiency. This review highlights types applications cancer diagnosis. study can provide inspiration impetus for exploiting more promising delivery.
Язык: Английский
Процитировано
3
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Апрель 16, 2024
Abstract We present, a facile method for the synthesis of block co-polymer [(PLA)-b-(Car)], (PLA-Poly Lactic acid and Car-Carbazole) followed by development cone ice-cream cup-shaped frustums with nanoporous capsules bio-sensing drug loading applications. Thermoplastic polyester PLA aminated an aromatic heterocyclic organic compound Car gives desired shape characteristics extended porosity on surface. The size, shape, morphology are tunable concerning solvents thermal treatment. Interestingly, hollow (half-broken coconut type) has been carried out without using any precursors surfactants. Synthesis [(PLA)-b-(Car)] confirmed through Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR; 1H 13C). However, surface properties were field emission scanning electron microscopy (FE-SEM), Bruner Emmett Teller (BET), atomic force (AFM) characterizations. capsule size ranges from ~200 nm to 1 µm (in diameter) scales ~60 80 nm. porous biosensing biomedical applications can be considered as unique novel characteristic property our invention. This kind ice cream used stimuli-responsive catalytic activity fluorescence measurement cysteine gold nanoparticle [(Cys)-(Au+)] enhanced payload
Язык: Английский
Процитировано
0
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 321, С. 124721 - 124721
Опубликована: Июнь 25, 2024
Язык: Английский
Процитировано
0
Diseases & Research, Год журнала: 2024, Номер 4(0), С. 1 - 8
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Genetics and Molecular Biology, Год журнала: 2024, Номер 47(3)
Опубликована: Янв. 1, 2024
Chemotherapy stands out as the main systemic treatment strategy against cancer and still faces problems related to multidrug resistance severe side effects. Copper-based drugs have been widely explored in medicinal chemistry, since copper is an essential metal for physiological activities with antineoplastic In this context, present study aimed evaluate recombinogenic/mutagenic anticarcinogenic potential of complex CBP-01 - [Cu(bta)(1,10-phen)ClO4] (Hbta = 4,4,4-trifluoro-1-phenyl-1,3-butanedione 1,10-phen =1,10-phenanthroline) through Somatic Recombination test (SMART) Epithelial Tumor Test (ETT) Drosophila melanogaster, compared carboplatin (CARB) cisplatin (CIS) According our results, CARB CIS induced a high frequency mutant spots, which was not verified at higher concentrations CBP-01. addition, exhibited mutagenic/recombinogenic only lowest concentration after biometabolization. Subsequently, ETT test, did demonstrate carcinogenic effect. Lastly, epithelial tumors were identified flies treated CIS, modulated by complex. Therefore, modulates genotoxicity other compounds promising metal-based drug development new anticancer agent or optimization therapeutic regimens.
Язык: Английский
Процитировано
0
Journal of Porous Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 20, 2024
Язык: Английский
Процитировано
0