Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Окт. 25, 2023
Abstract
We
investigated
the
relationship
between
foveal
avascular
zone
(FAZ)-related
parameters,
assessed
by
optical
coherence
tomography
angiography
(OCT-A),
and
visual
field
(VF)
progression
in
early-stage
open-angle
glaucoma
(OAG)
eyes
with
central
(CVF)
defects.
Early-stage
[VF
mean
deviation
(MD)
≥
−
6
dB]
CVF
defects
were
included.
The
rates
of
longitudinal
change
FAZ-related
parameters
structural
evaluated
compared
VF
progressors
non-progressors,
using
linear
mixed
effects
models.
Cox
proportional
hazards
model
regression
models
used
to
identify
factors
associated
progression,
MD
reduction
rate
total
12
points
(MTD
10
).
A
131
included
was
detected
32
(24.4%)
during
3.45
years
follow-up.
vessel
density
300
µm
width
annular
region
surrounding
FAZ
(FD300)
macular
ganglion
cell–inner
plexiform
layer
thickness
(mGCIPLT)
significantly
faster
than
non-progressors.
or
MTD
FD300
loss
mGCIPLT
reduction.
is
OAG
may
be
an
adjunctive
biomarker
glaucomatous
Frontiers in Medicine,
Год журнала:
2023,
Номер
10
Опубликована: Май 26, 2023
Glaucoma
is
a
chronic
neurodegenerative
disease,
which
the
leading
cause
of
irreversible
blindness
worldwide.
As
response
to
high
intraocular
pressure,
clinical
and
molecular
glaucoma
biomarkers
indicate
biological
state
visual
system.
Classical
uncovering
novel
development
progression,
follow-up,
monitoring
treatment
are
key
objectives
improve
vision
outcomes.
While
imaging
field
has
successfully
validated
disease
there
still
considerable
need
for
developing
new
early
glaucoma,
that
is,
at
preclinical
initial
stages.
Outstanding
trials
animal-model
study
designs,
innovative
technology,
analytical
approaches
in
bioinformatics
essential
tools
uncover
with
potential
translation
into
practice.To
better
understand
biochemical-molecular-genetic
pathogenesis,
we
conducted
an
analytical,
observational,
case-comparative/control
358
primary
open-angle
(POAG)
patients
226
comparative-control
individuals
(CG)
collect
tears,
aqueous
humor,
blood
samples
be
processed
identifying
POAG
by
exploring
several
pathways,
such
as
inflammation,
neurotransmitter/neurotrophin
alteration,
oxidative
stress,
gene
expression,
miRNAs
fingerprint
its
targets,
vascular
endothelial
dysfunction,
Statistics
were
done
using
IBM
SPSS
25.0
program.
Differences
considered
statistically
significant
when
p
≤
0.05.Mean
age
was
70.03
±
9.23
years,
70.62
7.89
years
CG.
Malondialdehyde
(MDA),
nitric
oxide
(NO),
interleuquin
(IL)-6,
endothelin-1
(ET-1),
5
hydroxyindolacetic
acid
(5-HIAA),
displayed
significantly
higher
levels
vs.
CG
(p
<
0.001).
Total
antioxidant
capacity
(TAC),
brain
derived
neurotrophic
factor
(BDNF),
5-hydroxy
tryptamine
(5-HT),
solute
carrier
family
23-nucleobase
transporters-member
2
(SLC23A2)
gene,
glutathione
peroxidase
4
(GPX4)
showed
lower
levelsin
than
The
differentially
expressed
tear
respect
hsa
miR-26b-5p
(involved
cell
proliferation
apoptosis),
miR-152-3p
(regulator
proliferation,
extracellular
matrix
expression),
miR-30e-5p
autophagy
miR-151a-3p
myoblast
proliferation).We
incredibly
enthusiastic
gathering
much
information
possible
on
learn
how
above
can
used
steer
diagnosis
therapy
prevent
predictable
future.
In
fact,
may
suggest
design
blended
more
appropriate
solution
ophthalmological
practice
predict
therapeutic
patients.
Clinical and Experimental Optometry,
Год журнала:
2024,
Номер
107(2), С. 122 - 129
Опубликована: Фев. 17, 2024
Detecting
deterioration
of
visual
field
sensitivity
measurements
is
important
for
the
diagnosis
and
management
glaucoma.
This
review
surveys
current
methods
assessing
progression
that
are
implemented
in
clinical
devices,
which
have
been
used
trials,
alongside
more
recent
advances
proposed
literature.
Advice
also
offered
to
clinicians
on
what
they
can
do
improve
collection
perimetric
data
help
analytical
accurately
predict
change.
advice
includes
a
discussion
how
frequently
testing
should
be
undertaken,
with
view
towards
future
developments,
such
as
digital
healthcare
outside
standard
setting
personalised
approaches
perimetry.
Journal of Glaucoma,
Год журнала:
2023,
Номер
33(3), С. 168 - 175
Опубликована: Окт. 17, 2023
Précis:
The
study
identified
risk
factors
for
exfoliation
glaucoma
and
recommended
re-evaluating
target
intraocular
pressure
(IOP)
after
5
visual
fields
to
slow
disease
progression.
Purpose:
This
aimed
establish
determine
the
earliest
time
points
estimating
Patients:
A
total
of
96
patients
with
newly
diagnosed
were
included.
Included
required
perform
at
least
7
field
tests
within
a
3-year
period
(±3
months).
All
treated
inclusion.
Methods:
was
nonrandomized,
prospective
cohort
study.
predictors
measured
included
IOP,
mean
deviation
(MD),
index
(VFI).
Progression
assessed
using
rate
progression
based
on
MD,
VFI,
“Guided
Analysis.”
Linear
or
logistic
regression
models
developed
variables
studied.
An
analysis
variance
used
point.
At
point,
retested.
area
under
receiver
operating
characteristic
curve
calculated.
Results:
general
−3.84
(±2.61)
dB
MD
values
9.66
(±6.25)
%
VFI
over
3
years.
diagnosis
both
linear
regression.
Analysis
post
hoc
Tukey
test
showed
significant
24
months
VFI.
Conclusions:
studied
(IOP,
VFI)
moderate
accuracy
baseline
but
excellent
predictive
capacity
postdiagnosis.
Re-evaluating
IOP
can
effectively
down
Molecular Aspects of Medicine,
Год журнала:
2023,
Номер
94, С. 101220 - 101220
Опубликована: Окт. 17, 2023
Glaucoma
is
the
leading
cause
of
irreversible
blindness
worldwide.
Currently
only
effective
treatment
for
glaucoma
to
reduce
intraocular
pressure,
which
can
halt
progression
disease.
Highlighting
importance
identifying
individuals
at
risk
developing
and
those
with
early-stage
will
help
patients
receive
before
sight
loss.
However,
some
cases
do
not
have
raised
pressure.
In
fact,
caused
by
a
variety
different
mechanisms
has
wide
range
subtypes.
Understanding
other
factors,
underlying
mechanisms,
pathology
might
lead
novel
treatments
diseases.
this
review
we
present
latest
research
into
including
genetics
molecular
basis
