The double-edged sword role of natural Killer cells in Parkinson's disease

Cellular Immunology, Год журнала: 2025, Номер 409-410, С. 104928 - 104928

Опубликована: Янв. 23, 2025

Язык: Английский

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Cerebrospinal fluid and blood neurofilament light chain in Parkinson's disease and atypical parkinsonian syndromes: a systematic review and Bayesian network meta-analysis

Journal of Neurology, Год журнала: 2025, Номер 272(4)

Опубликована: Апрель 1, 2025

Язык: Английский

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Association of the Monocyte-to-High Density Lipoprotein Ratio with the FRS and as a Predictor of Cardiovascular Risk in Individuals with Psoriasis Vulgaris

Clinical Cosmetic and Investigational Dermatology, Год журнала: 2025, Номер Volume 18, С. 1051 - 1062

Опубликована: Май 1, 2025

The monocyte-to-high-density lipoprotein ratio (MHR) has emerged as a novel inflammatory biomarker associated with cardiovascular diseases (CVDs). This retrospective study aimed to investigate the relationship between MHR and Framingham risk score (FRS) assess prognostic significance of this for mid- high-risk CVD in individuals psoriasis vulgaris (PsV). A total 128 PsV patients 120 healthy controls were included. neutrophil-to-high-density (NHR), MHR, neutrophil-to-lymphocyte (NLR) assessed compared two groups. Correlations FRS evaluated. intermediate high exhibited significantly higher NHR, NLR (p = 0.018, p 0.002, < 0.001, respectively). Furthermore, was positively correlated (r=0.27, 0.002; r=0.21, 0.017 r=0.33, Logistic regression analysis identified age, sex, influencing factors 0.05). Receiver operating characteristic (ROC) curve revealed that highest Youden's index (0.316) obtained at an 0.24, sensitivity, specificity, area under ROC 0.729, 0.587, 0.662 (95% CI 0.565, 0.758), respectively. FRS, which may serve valuable predictor medium CVDs PsV.

Язык: Английский

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Recent advances in fluid and tissue-based biomarkers for use in Parkinson’s disease

Expert Review of Neurotherapeutics, Год журнала: 2025, Номер unknown

Опубликована: Июнь 2, 2025

Parkinson's disease (PD) is a common neurodegenerative leading to motor and non-motor disabilities. Broadly accessible fluid- or tissue-based biomarkers will complement neuroimaging may allow earlier identification more precise tracking. The authors have reviewed the recent advances from original full text English-language articles that were indexed in PubMed database between June 2023 2024. Articles identified using MESH terms 'Parkinson's Disease' AND 'biomarkers' focused on fluid biomarker distinguish participants with PD healthy controls other conditions. most promising new are those measuring α-synuclein cerebrospinal skin biopsy. A significant limitation of these studies their reliance clinical diagnosis PD, mostly without neuropathological confirmation. Mounting evidence supports validity CSF biopsy-based detection for distinction controls, although not yet spectrum α-synucleinopathies nor non-α-synuclein forms parkinsonism. Nonetheless, potential detect individuals who develop revolutionize our ability test preventive interventions before symptoms develop. Machine-learning approaches offer strategies efficient validation novel biomarkers.

Язык: Английский

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The immune regulatory mechanism of ketamine-induced psychiatric disorders: A new perspective on drug-induced psychiatric symptoms

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2024, Номер 136, С. 111194 - 111194

Опубликована: Ноя. 12, 2024

Язык: Английский

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