Diffusion Tensor Imaging Along the Perivascular Space Is a Promising Imaging Method in Parkinson's Disease: A Systematic Review and Meta‐Analysis Study DOI Creative Commons
Kiarash Shirbandi,

Mostafa Jafari,

Fatemeh Mazaheri

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(5)

Опубликована: Май 1, 2025

ABSTRACT Introduction Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder that primarily affects motor functions. Recently, diffusion tensor imaging technique called DTI along the perivascular space (DTI‐ALPS) has gained attention as noninvasive biomarker for glymphatic function. This systematic review and meta‐analysis aimed to evaluate potential implications of DTI‐ALPS index diagnosing PD. Methods study followed PRISMA 2020 statement. Eligible cohort cross‐sectional studies measured ALPS in PD patients versus non‐PD participants. Web Science, Medline, Scopus, Embase, Cochrane, PROSPERO, ICTRP databases were explored until November 14, 2024. Two researchers independently screened studies, extracted data, assessed risk bias using Newcastle–Ottawa Scale (NOS). The used random effects model (REM), assessing heterogeneity ( I 2 , Q‐test) publication (Egger's test, trim&fill plot). certainty evidence was evaluated GRADE approach. Results 11 involving 1462 (855 PD, 607 both genders), yielded significant findings. overall differed substantially between groups (SMD: −0.61, 95% CI: −0.72, −0.50, p < 0.001). Additionally, negative correlation emerged Unified Rating III (UPDRS III) (r = −0.40, (95% −0.59, −0.18, : 89.81, 0.001)), indicating dysfunction's impact on cognitive decline. However, weak statistically non‐significant observed Montreal Cognitive Assessment (MoCA) r 0.24, −0.32 0.68), with high across 87.37, 0.001 heterogeneity). Publication low index. Conclusion These findings highlight diagnosis progression monitoring. Further are warranted explore its applicability differentiating from other disorders.

Язык: Английский

Glymphatic system: a self-purification circulation in brain DOI Creative Commons
Siying Chen, Huijing Wang,

Luhan Zhang

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 12, 2025

The glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal interstitial (CSF-ISF) moves from perivascular spaces (PVS) of arteries to those veins for drainage. Aquaporin-4 (AQP4) plays crucial role driving within PVS. impairment AQP4 is closely linked dysfunction system. function less active during waking but enhanced sleep. efficiency decreases with aging. Damage will give rise development progression many brain diseases, such as Alzheimer’s disease (AD), Parkinson’s (PD), chronic traumatic encephalopathy (CTE), vascular dementia (VaD). we reviewed previous research associated system, including its concepts, principles, influencing factors. We hypothesize that could be target prevention treatment certain diseases through regulation

Язык: Английский

Процитировано

0
Exploring glymphatic system alterations in iRBD and Parkinson’s disease using automated DTI-ALPS analysis DOI Creative Commons
Stanislav Mareček,

Veronika Rottova,

Jiří Nepožitek

и другие.

npj Parkinson s Disease, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 15, 2025

Abstract Diffusion tensor image analysis along the perivascular space (DTI-ALPS) is a potential non-invasive marker of glymphatic function that typically relies on manual region interest (ROI) placement. This study compared ALPS indices in treatment-naïve, de novo diagnosed patients with Parkinson’s disease (PD), isolated REM behavior disorder (iRBD), and healthy controls using both automatic approaches to ROI selection used ALPS-index calculation. were analyzed bilaterally correlated clinical severity (MDS-UPDRS) nigrostriatal denervation (DAT-SPECT). ANCOVA revealed significant inter-group differences ( p = 0.018) 0.002) methods. The approach showed significantly lower PD 0.001) iRBD 0.009). symptom denervation. These findings underscore reliability placement for index calculation may indicate early alterations disease.

Язык: Английский

Процитировано

0
Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD DOI Creative Commons
Ignacio Roura, Jèssica Pardo, Cristina Martín‐Barceló

и другие.

npj Parkinson s Disease, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

0
Diffusion Tensor Imaging Along the Perivascular Space Is a Promising Imaging Method in Parkinson's Disease: A Systematic Review and Meta‐Analysis Study DOI Creative Commons
Kiarash Shirbandi,

Mostafa Jafari,

Fatemeh Mazaheri

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(5)

Опубликована: Май 1, 2025

ABSTRACT Introduction Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder that primarily affects motor functions. Recently, diffusion tensor imaging technique called DTI along the perivascular space (DTI‐ALPS) has gained attention as noninvasive biomarker for glymphatic function. This systematic review and meta‐analysis aimed to evaluate potential implications of DTI‐ALPS index diagnosing PD. Methods study followed PRISMA 2020 statement. Eligible cohort cross‐sectional studies measured ALPS in PD patients versus non‐PD participants. Web Science, Medline, Scopus, Embase, Cochrane, PROSPERO, ICTRP databases were explored until November 14, 2024. Two researchers independently screened studies, extracted data, assessed risk bias using Newcastle–Ottawa Scale (NOS). The used random effects model (REM), assessing heterogeneity ( I 2 , Q‐test) publication (Egger's test, trim&fill plot). certainty evidence was evaluated GRADE approach. Results 11 involving 1462 (855 PD, 607 both genders), yielded significant findings. overall differed substantially between groups (SMD: −0.61, 95% CI: −0.72, −0.50, p < 0.001). Additionally, negative correlation emerged Unified Rating III (UPDRS III) (r = −0.40, (95% −0.59, −0.18, : 89.81, 0.001)), indicating dysfunction's impact on cognitive decline. However, weak statistically non‐significant observed Montreal Cognitive Assessment (MoCA) r 0.24, −0.32 0.68), with high across 87.37, 0.001 heterogeneity). Publication low index. Conclusion These findings highlight diagnosis progression monitoring. Further are warranted explore its applicability differentiating from other disorders.

Язык: Английский

Процитировано

0