Juvenile fluoxetine treatment affects the maturation of the medial prefrontal cortex and behavior of adolescent female rats DOI
Joanna Kryst, Agnieszka Chocyk, Anna Solarz

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Abstract Background Serotonin is strongly involved in the regulation of brain development. An early-life imbalance serotonin levels may influence proper formation neuronal circuits and synaptic plasticity. One factors that can affect concentrations exposure to fluoxetine (FLX), a selective reuptake inhibitor, first-line pharmacological treatment for depression anxiety pediatric population. Women are more prone from young age. The safety FLX still questionable. We hypothesized juvenile influences maturation behavior adolescent females. Methods On postnatal days (PNDs) 20–28, female rats were injected once daily with FLX. Five later, anxiety- fear-related behaviors response amphetamine assessed. PND 40, numbers neurons glial cells medial prefrontal cortex (mPFC) hippocampus estimated via stereological methods. Additionally, mRNA expression cell survival/apoptosis plasticity markers was evaluated RT‒qPCR. Results Juvenile attenuated anxiety-like behaviors, impaired fear memory blunted locomotor Simultaneously, increased regional volume astrocytes specific subregions mPFC but not hippocampus. FLX-treated females presented genes regulating survival reduced AMPA glutamate receptors mPFC. Conclusions affects mPFC; therefore, this psychotropic drug should be used caution people.

Язык: Английский

Juvenile fluoxetine treatment affects the maturation of the medial prefrontal cortex and behavior of adolescent female rats DOI
Joanna Kryst, Agnieszka Chocyk, Anna Solarz

и другие.

Pharmacological Reports, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Язык: Английский

Процитировано

1

Maternal fluoxetine impairs synaptic transmission and plasticity in the medial prefrontal cortex and alters the structure and function of dorsal raphe nucleus neurons in offspring mice DOI Creative Commons
Bartosz Bobula,

Joanna Bąk,

Agnieszka Kania

и другие.

Pharmacology Biochemistry and Behavior, Год журнала: 2024, Номер 244, С. 173849 - 173849

Опубликована: Авг. 13, 2024

Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are commonly prescribed to women during pregnancy and breastfeeding despite posing a risk of adverse cognitive outcomes affective disorders for the child. The consequences SSRI-induced excess 5-HT development brain neuromodulatory system remain largely unexplored. In this study, an SSRI - fluoxetine (FLX) was administered C57BL/6 J mouse dams lactation assess its effects on offspring. We found that maternal FLX decreased field potentials, impaired long-term potentiation, facilitated depression tended increase density 5-HTergic fibers in medial prefrontal cortex (mPFC) female but not male adolescent These were accompanied by deteriorated performance temporal order memory task reduced sucrose preference with no change marble burying behavior FLX-exposed also axodendritic tree complexity dorsal raphe nucleus (DRN) neurons offspring, changes excitability DRN either sex. While inhibitory postsynaptic currents (sIPSCs) found, we observed significant influence exposure kinetics spontaneous excitatory (sEPSCs) neurons. Finally, report potentials synaptic plasticity evident mPFC offspring after new antidepressant, vortioxetine. findings show contrast mPFC, structure function mild suggest sex-dependent, distinct sensitivity cortical brainstem early life. Vortioxetine appears exert fewer side regards when compared FLX. Created BioRender.com • Maternal alters cortex. increases innervation reduces more pronounced females than males. vortioxetine does alter plasticity.

Язык: Английский

Процитировано

4

The 5-HT7 receptor antagonist SB 269970 ameliorates maternal fluoxetine exposure-induced impairment of synaptic plasticity in the prefrontal cortex of the offspring female mice DOI Creative Commons
Bartosz Bobula, Magdalena Kusek, Grzegorz Hess

и другие.

Pharmacology Biochemistry and Behavior, Год журнала: 2024, Номер 240, С. 173779 - 173779

Опубликована: Апрель 28, 2024

The use of a selective serotonin reuptake inhibitor fluoxetine in depression during pregnancy and the postpartum period might increase risk affective disorders cognitive symptoms progeny. In animal models, maternal exposure to throughout gestation lactation negatively affects behavior offspring. Little is known about effects on synaptic transmission plasticity offspring cerebral cortex. During C57BL/6J mouse dams received (7.5 mg/kg/day) with drinking water. Female mice intraperitoneal injections 5-HT

Язык: Английский

Процитировано

2

Juvenile fluoxetine treatment affects the maturation of the medial prefrontal cortex and behavior of adolescent female rats DOI
Joanna Kryst, Agnieszka Chocyk, Anna Solarz

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Abstract Background Serotonin is strongly involved in the regulation of brain development. An early-life imbalance serotonin levels may influence proper formation neuronal circuits and synaptic plasticity. One factors that can affect concentrations exposure to fluoxetine (FLX), a selective reuptake inhibitor, first-line pharmacological treatment for depression anxiety pediatric population. Women are more prone from young age. The safety FLX still questionable. We hypothesized juvenile influences maturation behavior adolescent females. Methods On postnatal days (PNDs) 20–28, female rats were injected once daily with FLX. Five later, anxiety- fear-related behaviors response amphetamine assessed. PND 40, numbers neurons glial cells medial prefrontal cortex (mPFC) hippocampus estimated via stereological methods. Additionally, mRNA expression cell survival/apoptosis plasticity markers was evaluated RT‒qPCR. Results Juvenile attenuated anxiety-like behaviors, impaired fear memory blunted locomotor Simultaneously, increased regional volume astrocytes specific subregions mPFC but not hippocampus. FLX-treated females presented genes regulating survival reduced AMPA glutamate receptors mPFC. Conclusions affects mPFC; therefore, this psychotropic drug should be used caution people.

Язык: Английский

Процитировано

0