Juvenile fluoxetine treatment affects the maturation of the medial prefrontal cortex and behavior of adolescent female rats
Pharmacological Reports,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Язык: Английский
Maternal fluoxetine impairs synaptic transmission and plasticity in the medial prefrontal cortex and alters the structure and function of dorsal raphe nucleus neurons in offspring mice
Pharmacology Biochemistry and Behavior,
Год журнала:
2024,
Номер
244, С. 173849 - 173849
Опубликована: Авг. 13, 2024
Selective
serotonin
(5-HT)
reuptake
inhibitors
(SSRIs)
are
commonly
prescribed
to
women
during
pregnancy
and
breastfeeding
despite
posing
a
risk
of
adverse
cognitive
outcomes
affective
disorders
for
the
child.
The
consequences
SSRI-induced
excess
5-HT
development
brain
neuromodulatory
system
remain
largely
unexplored.
In
this
study,
an
SSRI
-
fluoxetine
(FLX)
was
administered
C57BL/6
J
mouse
dams
lactation
assess
its
effects
on
offspring.
We
found
that
maternal
FLX
decreased
field
potentials,
impaired
long-term
potentiation,
facilitated
depression
tended
increase
density
5-HTergic
fibers
in
medial
prefrontal
cortex
(mPFC)
female
but
not
male
adolescent
These
were
accompanied
by
deteriorated
performance
temporal
order
memory
task
reduced
sucrose
preference
with
no
change
marble
burying
behavior
FLX-exposed
also
axodendritic
tree
complexity
dorsal
raphe
nucleus
(DRN)
neurons
offspring,
changes
excitability
DRN
either
sex.
While
inhibitory
postsynaptic
currents
(sIPSCs)
found,
we
observed
significant
influence
exposure
kinetics
spontaneous
excitatory
(sEPSCs)
neurons.
Finally,
report
potentials
synaptic
plasticity
evident
mPFC
offspring
after
new
antidepressant,
vortioxetine.
findings
show
contrast
mPFC,
structure
function
mild
suggest
sex-dependent,
distinct
sensitivity
cortical
brainstem
early
life.
Vortioxetine
appears
exert
fewer
side
regards
when
compared
FLX.
Created
BioRender.com
•
Maternal
alters
cortex.
increases
innervation
reduces
more
pronounced
females
than
males.
vortioxetine
does
alter
plasticity.
Язык: Английский
The 5-HT7 receptor antagonist SB 269970 ameliorates maternal fluoxetine exposure-induced impairment of synaptic plasticity in the prefrontal cortex of the offspring female mice
Pharmacology Biochemistry and Behavior,
Год журнала:
2024,
Номер
240, С. 173779 - 173779
Опубликована: Апрель 28, 2024
The
use
of
a
selective
serotonin
reuptake
inhibitor
fluoxetine
in
depression
during
pregnancy
and
the
postpartum
period
might
increase
risk
affective
disorders
cognitive
symptoms
progeny.
In
animal
models,
maternal
exposure
to
throughout
gestation
lactation
negatively
affects
behavior
offspring.
Little
is
known
about
effects
on
synaptic
transmission
plasticity
offspring
cerebral
cortex.
During
C57BL/6J
mouse
dams
received
(7.5
mg/kg/day)
with
drinking
water.
Female
mice
intraperitoneal
injections
5-HT
Язык: Английский
Juvenile fluoxetine treatment affects the maturation of the medial prefrontal cortex and behavior of adolescent female rats
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
Background
Serotonin
is
strongly
involved
in
the
regulation
of
brain
development.
An
early-life
imbalance
serotonin
levels
may
influence
proper
formation
neuronal
circuits
and
synaptic
plasticity.
One
factors
that
can
affect
concentrations
exposure
to
fluoxetine
(FLX),
a
selective
reuptake
inhibitor,
first-line
pharmacological
treatment
for
depression
anxiety
pediatric
population.
Women
are
more
prone
from
young
age.
The
safety
FLX
still
questionable.
We
hypothesized
juvenile
influences
maturation
behavior
adolescent
females.
Methods
On
postnatal
days
(PNDs)
20–28,
female
rats
were
injected
once
daily
with
FLX.
Five
later,
anxiety-
fear-related
behaviors
response
amphetamine
assessed.
PND
40,
numbers
neurons
glial
cells
medial
prefrontal
cortex
(mPFC)
hippocampus
estimated
via
stereological
methods.
Additionally,
mRNA
expression
cell
survival/apoptosis
plasticity
markers
was
evaluated
RT‒qPCR.
Results
Juvenile
attenuated
anxiety-like
behaviors,
impaired
fear
memory
blunted
locomotor
Simultaneously,
increased
regional
volume
astrocytes
specific
subregions
mPFC
but
not
hippocampus.
FLX-treated
females
presented
genes
regulating
survival
reduced
AMPA
glutamate
receptors
mPFC.
Conclusions
affects
mPFC;
therefore,
this
psychotropic
drug
should
be
used
caution
people.
Язык: Английский