Non-apoptotic cell death in osteoarthritis: Recent advances and future
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117344 - 117344
Опубликована: Авг. 27, 2024
Osteoarthritis
(OA)
is
the
most
common
degenerative
joint
disease.
Multiple
tissues
are
altered
during
development
of
OA,
resulting
in
pain
and
permanent
damage
to
osteoarticular
joints.
Current
research
has
demonstrated
that
non-apoptotic
cell
death
plays
a
crucial
role
OA.
With
continuous
targeted
therapies,
shown
great
potential
prevention
treatment
We
systematically
reviewed
progress
on
pathogenesis,
development,
outcome
including
autophagy,
pyroptosis,
ferroptosis,
necroptosis,
immunogenic
death,
parthanatos.
This
article
reviews
mechanism
OA
provides
theoretical
basis
for
identification
new
targets
treatment.
Язык: Английский
Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101323 - 101323
Опубликована: Ноя. 8, 2024
Intervertebral
disc
degeneration
(IDD)
is
a
common
degenerative
disease
of
the
spine
that
has
significant
impact
on
both
society
and
human
health.
Many
studies
have
confirmed
there
close
relationship
between
IDD
senescence
apoptosis,
autophagy
can
combat
apoptosis
senescence.
Spatholobi
caulis
(SC)
an
herb
contains
various
active
compounds
are
effective
in
tissue
repair
regeneration,
but
it
not
been
explored
field
IDD.
In
this
study,
was
first
found
SC
boost
reduce
Nucleus
pulposus
cell
(NPCs).
However,
our
animal
revealed
limited
absorption
SC.
To
improve
bioavailability
efficacy
SC,
we
developed
hydrogel
incorporating
quaternary
ammonium
chitosan
(QCS)
oxidized
starch
(OST)
as
carriers
for
The
QCS-OST/SC
exhibits
excellent
compatibility
with
cells,
be
easily
injected,
release
durably.
At
cellular
level,
enhances
viability,
initiates
extracellular
matrix
(ECM),
inhibits
apoptosis.
injection
via
microneedles
(MNs)
into
discs
had
successfully
diminished
rats,
which
shows
broad
potential
treatment
Язык: Английский
Modulating Autophagy in Osteoarthritis: Exploring Emerging Therapeutic Drug Targets
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13695 - 13695
Опубликована: Дек. 21, 2024
Osteoarthritis
(OA)
is
a
degenerative
joint
disease
characterized
by
the
breakdown
of
cartilage
and
subsequent
inflammation
tissues,
leading
to
pain
reduced
mobility.
Despite
advancements
in
symptomatic
treatments,
disease-modifying
therapies
for
OA
remain
limited.
This
narrative
review
examines
dual
role
autophagy
OA,
emphasizing
its
protective
functions
during
early
stages
potential
contribute
degeneration
later
stages.
By
delving
into
molecular
pathways
that
regulate
autophagy,
this
highlights
intricate
interplay
with
oxidative
stress
inflammation,
key
drivers
progression.
Emerging
therapeutic
strategies
aimed
at
modulating
are
explored,
including
pharmacological
agents
such
as
AMP
kinase
activators,
microRNA-based
therapies.
Preclinical
studies
reveal
encouraging
results,
demonstrating
enhancing
can
reduce
decelerate
degradation.
However,
benefits
modulation
depend
on
precise,
stage-specific
approaches.
Excessive
or
dysregulated
advanced
may
lead
chondrocyte
apoptosis,
exacerbating
damage.
underscores
promise
autophagy-based
interventions
bridging
gap
between
experimental
research
clinical
application.
advancing
our
understanding
autophagy’s
these
findings
pave
way
innovative
effective
Nonetheless,
further
essential
optimize
strategies,
address
off-target
effects,
develop
safe,
targeted
treatments
improve
outcomes
patients.
Язык: Английский