Unraveling the Connection Between Ion Channels and Pancreatic Stellate Cell Activation
Cellular Physiology and Biochemistry,
Год журнала:
2025,
Номер
59(S1), С. 25 - 40
Опубликована: Янв. 18, 2025
Quiescent
pancreatic
stellate
cells
(PSCs)
represent
only
a
very
low
proportion
of
the
tissue,
but
their
activation
leads
to
stroma
remodeling
and
fibrosis
associated
with
pathologies
such
as
chronic
pancreatitis
ductal
adenocarcinoma
(PDAC).
PSC
can
be
induced
by
various
stresses,
including
acidosis,
growth
factors
(PDGF,
TGFβ),
hypoxia,
high
pressure,
or
intercellular
communication
cancer
cells.
Activated
targeting
represents
promising
therapeutic
strategy,
little
is
known
regarding
molecular
mechanisms
underlying
PSCs.
Identification
new
biomarkers
desmoplasia
in
PDAC
could
lead
targets
for
exocrine
disease
treatments.
Ion
channels
transporters
are
transmembrane
proteins
involved
numerous
physiological
pathological
processes,
PDAC.
They
well
act
biosensors
tissue
microenvironment,
they
easily
accessible
drugs.
However,
role
not
fully
understood.
In
this
review,
we
briefly
discuss
activated
PSCs
pancreas
inflammation
(associated
PDAC),
describe
specific
ion
(Ca2+,
K+,
Na+
Cl-)
these
processes
light
recent
literature.
Язык: Английский
Transient Receptor Potential Channels in Prostate Cancer: Associations with ERG Fusions and Survival
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3639 - 3639
Опубликована: Апрель 11, 2025
Calcium
movement
and
concentration
in
the
cell
plays
significant
roles
normal
physiology
diseases
such
as
cancer.
The
significance
of
this
ion
oncogenesis
suggests
that
membrane-relevant
proteins
are
involved
its
regulation
deregulated
various
cancers.
These
channels
transporters
could
be
targets
for
therapeutic
interventions.
An
evaluation
expression
transient
receptor
potential
(TRP)
prostate
cancer
was
performed
using
publicly
available
genomic
proteome
data.
Two
TRP
family
members
with
high
cancers,
TRPML2
TRPM4,
were
chosen
further
analysis
uncover
associations
their
level
clinical
pathologic
characteristics.
Several
expressed
cancers
at
protein
including
TRPML1,
TRPML2,
TRPC1
TRPP3.
At
mRNA
level,
MCOLN2
TRPM4
strongly
a
sub-set
Cases
associated
frequent
ERG
fusions
trend
better
survival
outcomes.
In
contrast,
cases
lower
fusion
frequency
than
low
expression.
prognosis
not
different
from
counterparts
having
sub-sets
two
well-expressed
super
family,
have
divergent
most
prevalent
molecular
aberrations,
fusions.
results
imply
diverse
regulations
would
to
taken
into
consideration
when
devising
interventions
targeting
individual
channels.
Язык: Английский
Two-pore-domain potassium channel Sandman regulates intestinal stem cell homeostasis and tumorigenesis in Drosophila melanogaster
Journal of genetics and genomics/Journal of Genetics and Genomics,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
Язык: Английский
Evolution of Bioelectric Membrane Potentials: Implications in Cancer Pathogenesis and Therapeutic Strategies
The Journal of Membrane Biology,
Год журнала:
2024,
Номер
257(5-6), С. 281 - 305
Опубликована: Авг. 25, 2024
Язык: Английский
Exploring Ion Channel Magnetic Pharmacology: Are Magnetic Cues a Viable Alternative to Ion Channel Drugs?
BioEssays,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
ABSTRACT
We
explore
the
potential
of
using
magnetic
cues
as
a
novel
approach
to
modulating
ion
channel
expression,
which
could
provide
an
alternative
traditional
pharmacological
interventions.
Ion
channels
are
crucial
targets
for
therapies,
and
ongoing
research
in
this
field
continues
introduce
new
methods
treating
various
diseases.
However,
efficacy
drugs
is
often
compromised
by
issues
such
target
selectivity,
leading
side
effects,
toxicity,
complex
drug
interactions.
These
challenges,
along
with
problems
like
resistance
difficulties
crossing
biological
barriers,
highlight
need
innovative
strategies.
In
context,
proposed
use
modulate
expression
may
offer
promising
solution
address
these
limitations,
potentially
improving
safety
effectiveness
treatments,
particularly
long‐term
use.
Key
developments
area
reviewed,
relationships
between
changes
fields
summarized,
knowledge
gaps
identified,
central
relevant
future
discussed.
Язык: Английский
Role of Bioelectrical Signaling Networks in Tumor Growth
Taleh Yusifov,
Fidan Qudretova,
Aysel Aliyeva
и другие.
American Journal of Biomedical and Life Sciences,
Год журнала:
2024,
Номер
12(5), С. 83 - 92
Опубликована: Ноя. 28, 2024
The
ion
channels
are
distributed
in
all
cells
and
promote
the
rapid
influx
of
ions
that
underlie
formation
cellular
bioelectrical
signals.
Bioelectrical
signals
coupled
with
other
regulator
mechanisms
provide
fundamental
physiological
processes,
such
as
differentiation,
proliferation,
apoptosis,
which
strongly
associated
manifestation
cancer
hallmarks.
Alterations
signaling
mechanism
unusual
features
cells.
Investigating
role
tumor
growth
provides
insights
into
diagnosis
tumor-targeted
treatment.
Hence,
this
field
research
is
becoming
one
frontrunners
medicine,
advances
biophysical
tools
enabling
progress
understanding
biological
phenomenon.
Recent
studies
have
revealed
represent
a
promising
target
therapy.
It
increasingly
convincing
conditions
can
be
reversed
to
normal
by
regulating
Herein,
we
brief
review
pathophysiology
data
on
manipulation
novel
approach
preventing
malignant
growth.
Язык: Английский