Shaping the Future of Cardiac Wellness: Exploring Revolutionary Approaches in Disease Management and Prevention

Journal of Clinical Cardiology, Год журнала: 2024, Номер 5(1), С. 6 - 29

Опубликована: Янв. 5, 2024

Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide. Effective prevention management strategies are essential to reduce the burden CVDs. This review summarizes recent advances in In terms prevention, lifestyle modifications, such as diet, exercise, smoking cessation, important strategies. Pharmacological interventions, including statins, antiplatelet agents, antihypertensive medications, have also shown benefits. Innovative approaches, genetic testing risk stratification, targeted strategies, use mobile health technology, being explored. management, acute reperfusion therapy for myocardial infarction, heart failure stroke improved outcomes. Chronic medical failure, arrhythmia device precision medicine personalized treatment, artificial intelligence diagnosis traditional Chinese regenerative medicine, investigated. While CVDs promising, challenges implementing these cost-effectiveness, access care, resistance change clinical practice. Continued research innovation improve patient

Язык: Английский

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Association between activity quotient and cause-specific mortality – A prospective cohort study of 0.5 million participants in Asia

Progress in Cardiovascular Diseases, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Год журнала: 2024, Номер unknown

Опубликована: Июль 22, 2024

Abstract Systemic aging influences various physiological processes and contributes to structural functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a diastolic function, atrial dilation, fibrillation, myocardial fibrosis amyloidosis, elevating susceptibility chronic heart failure (HF) the elderly. Age‐related dysfunction stems from prolonged exposure genomic, epigenetic, oxidative, autophagic, inflammatory regenerative stresses, along with accumulation senescent cells. Concurrently, age‐related changes vascular system, attributed endothelial dysfunction, arterial stiffness, impaired angiogenesis, oxidative stress inflammation, impose additional strain on heart. Dysregulated mechanosignalling nitric oxide signalling play critical roles associated HF. Metabolic drives intricate shifts glucose lipid metabolism, leading insulin resistance, mitochondrial within cardiomyocytes. contribute contractility, ultimately propelling low‐grade conjunction senescence‐associated secretory phenotype, aggravates age by promoting immune cell infiltration into myocardium, fostering This is further exacerbated comorbidities like coronary artery disease (CAD), atherosclerosis, hypertension, obesity, diabetes kidney (CKD). CAD atherosclerosis induce ischaemia adverse remodelling, while hypertension hypertrophy fibrosis. Obesity‐associated inflammation dyslipidaemia create profibrotic environment, whereas diabetes‐related metabolic disturbances impair function. CKD‐related fluid overload, electrolyte imbalances uraemic toxins exacerbate HF through systemic neurohormonal renin‐angiotensin‐aldosterone system (RAAS) activation. Recognizing as modifiable process has opened avenues target both lifestyle interventions therapeutics. Exercise, known for its antioxidant effects, can partly reverse pathological remodelling elderly countering linked HF, such senescence declining cardiomyocyte regeneration. Dietary plant‐based ketogenic diets, caloric restriction macronutrient supplementation are instrumental maintaining energy balance, reducing adiposity addressing micronutrient Therapeutic advancements targeting underway. Key approaches senomorphics senolytics limit senescence, antioxidants stress, anti‐inflammatory drugs interleukin (IL)‐1β inhibitors, rejuvenators nicotinamide riboside, resveratrol sirtuin (SIRT) activators autophagy enhancers metformin sodium‐glucose cotransporter 2 (SGLT2) all which offer potential preserving function alleviating burden.

Язык: Английский

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Special Issue: “New Trends in Diabetes, Hypertension, and Cardiovascular Diseases—2nd Edition”

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 449 - 449

Опубликована: Янв. 7, 2025

Cardiovascular diseases (CVDs) encompass a range of conditions affecting both the heart (e.g., coronary disease and failure [1]) blood vessels cerebrovascular [2] peripheral artery [3]) [...].

Язык: Английский

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Effects of Healthy Lifestyles on Chronic Diseases: Diet, Sleep and Exercise

Nutrients, Год журнала: 2023, Номер 15(21), С. 4627 - 4627

Опубликована: Окт. 31, 2023

Among the many factors affecting general health and resilience to disease, lifestyle is at same time most controllable influential factor [...]

Язык: Английский

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Cardiorespiratory fitness, perceived fitness and autonomic function in in-patients with different depression severity compared with healthy controls

Journal of Psychiatric Research, Год журнала: 2024, Номер 175, С. 437 - 445

Опубликована: Май 21, 2024

Over 300 million individuals worldwide suffer from major depressive disorder (MDD). Individuals with MDD are less physically active than healthy people which results in lower cardiorespiratory fitness (CRF) and favorable perceived compared controls. Additionally, may show autonomic system dysfunction. The purpose of the present study was to evaluate CRF, function in-patients different severity We used data 212 (age: 40.7 ± 12.6 y, 53% female) 141 controls 36.7 12.7 58% female). assessed CRF Åstrand-Rhyming test, self-reported by heart rate variability (HRV). In specific, we resting rate, time- frequency-based parameters for HRV. In-patients completed Beck Depression Inventory-II (BDI-II) self-assess subjectively rated depression. Based on these scores, participants were grouped into mild, moderate severe MDD. main finding an inverse association between depression as well Resting elevated increasing severity. time-based but not showed pattern suggests that among disorder, those particularly high self-assessed scores a partial dysfunction To counteract conditions, physical activity interventions be effective.

Язык: Английский

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Influencing basic behavioral mechanisms of action while targeting daily walking in sedentary adults at risk for cardiovascular disease: randomised factorial design protocol

BMJ Open, Год журнала: 2025, Номер 15(1), С. e080307 - e080307

Опубликована: Янв. 1, 2025

Introduction Cardiovascular disease (CVD) is the leading cause of mortality worldwide, though it may be prevented by increasing physical activity (PA). When behaviour change techniques (BCTs) are bundled together, they increase PA, which individual BCTs PA (and behavioural mechanism action (MoA) responsible for said increase) have not been studied. The aim this study to conduct a randomised factorial experiment determine four significantly engage proposed MoA—self-efficacy PA—in adults at risk CVD. Methods and analysis Eight hundred twenty sedentary (18–74 years old) CVD will recruited between September 2022 June 2025 fully remote, 24-week BCT intervention. To identify those who might benefit from intervention, we define self-reported walking <7500 steps per day as ‘sedentary'. Following 4-week run-in period confirm adherence protocol, 624 eligible participants an 8-week intervention period. A full conducted with 16 possible conditions: one receive no (no-BCT condition), another all four, 14 unique combination BCTs. During their daily BCT(s) via text message. Daily continuously measured using tracker. Self-efficacy assessed bi-weekly Self-Efficacy Walking Scale–Duration. Participants complete 12-week post-intervention follow-up where monitored despite being delivered. associated increased step counts self-efficacy completion (week 12 follow-up) determined alongside whether or mediates association each walking. Ethics dissemination This trial was approved Northwell Health Institutional Review Board. experimental results published in peer-reviewed journal. Data clinical made available on reasonable request. Trial registration number clinicaltrials.gov; Identifier: NCT05425641 , 06/21/2022

Язык: Английский

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Health is beyond genetics: on the integration of lifestyle and environment in real-time for hyper-personalized medicine

Frontiers in Public Health, Год журнала: 2025, Номер 12

Опубликована: Янв. 7, 2025

Hyper-personalized medicine represents the cutting edge of healthcare, which aims to tailor treatment and prevention strategies uniquely each individual. Unlike traditional approaches, often adopt a one-size-fits-all or even broadly personalized approach based on broad genetic categories, hyper-personalized considers an individual's comprehensive health data by integrating unique biological, genetic, lifestyle, environmental influences. This method goes beyond simple profiling recognizing that outcomes are influenced complex interactions among our environment, daily routines, physiological processes responses.Central is integration lifestyle factors. Lifestyle habits, such as diet (Dalwood et al., 2020; Genel Marx Hepsomali & Groeger, 2021; Dinu 2022; Yang Sadler 2024), exercise (Chow Qiu Ross D'Onofrio 2023; Isath Mahindru Ashcroft 2024; Ponzano sleep patterns (Hepsomali Baranwal Eshera Lim Sletten Uccella, Weinberger 2023), directly impact health. Hence, understanding these factors helps interventions align with day-to-day realities Environmental factors, air quality (Cheek Markandeya Shukla Tang Abdul-Rahman Bedi Bhattacharya, climate (Coates Ebi Helldén Reismann Rocque Zhang Münzel Palmeiro-Silva exposure pollutants (Qadri Faiq, 2019; Petroni Lin Sun Xu Yu Levin Shetty Deziel Villanueva Sharma also play significant roles in determining outcomes. By continuously monitoring analyzing elements, healthcare providers can create dynamic plans adapt real-time changes. would allow for proactive measures optimized care.To enable model care, advanced technologies like quantum computing, artificial general intelligence (AGI), internet things (IoT), 6G connectivity crucial roles. Quantum computing offers ability process vast intricate datasets, those required between markers, exposures, choices, far greater speed accuracy than classical (Munshi Kumar Stefano, Ullah Garcia-Zapirain, 2024). AGI, its adaptive learning capabilities, analyze make sense this provide precise, evolving recommendations change patient's environment does (Liu Mitchell, Tu IoT devices, including wearables sensors, gather continuous from individuals, tracking physical activity, biometrics, conditions humidity (Puri Islam Mathkor Rocha Šajnović Salam, With advent connectivity, seamlessly transferred processed real time, enabling instant feedback intervention (Nayak Patgiri, Nguyen Ahad Kumar, Kaur, Mahmood Mihovska 2024).Together, form backbone model, will push medical practices highly responsive, individual-centered As advancements continue evolve, has potential fundamentally reshape offering truly support long-term well-being.

Язык: Английский

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Physical activity, Vitamin D, and all-cause/cardiovascular mortality: a prospective study in older Chinese adults

BMC Geriatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 16, 2025

Physical activity was associated with the risk of all-cause and cardiovascular mortality. However, little is known about older adults, especially those aged over 80 years. 2863 adults in Chinese Longitudinal Healthy Longevity Survey (CLHLS) were enrolled. score used to evaluate physical activity. Serum 25-hydroxyvitamin D demographic characteristics collected at baseline. We multivariable-adjusted Cox regression models stratified analysis determine association between activity, vitamin all-cause/cardiovascular Mediation performed mediating effect The median age this population 87 years, 70.27% oldest-old (age ≥ years). observed a tendency for higher concentration participants levels. Both levels inversely mortality all participants. Between mortality, mediation proportions 7.76% (P < 0.001) 4.13% 0.001), respectively. remained significant various types activities. Furthermore, accounted greater proportion activities housework raising domestic animals/pets. could reduce mediated by adults.

Язык: Английский

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Psychological and Behavioural Factors That Impact on the Mental Health of University Students

Mental Illness, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

The prevalence of mental health problems, particularly depression and anxiety among university students, has increased drastically since the COVID‐19 pandemic. In this cross‐sectional study, we take three factors that evidence suggests should have an impact on student health—sleep, exercise, alcohol consumption—and add a novel factor preference for solitude (PFS). This particular been chosen as post‐COVID‐19; it indicated there are fewer interactions lower sense community belonging amongst younger people, may individual students in different ways relative to their social interaction or solitude. current study recruited 290 participants from University Birmingham measured using Patient Health Questionnaire (PHQ‐9) generalised disorder (GAD‐7) questionnaire measures. Sleep was Condition Indicator (SCI), PFS Preference Solitude Scale (PSS), exercise used Recent Physical Activity (RPAQ), consumption by units consumed per week. Correlational analysis multiple regression analyses were determine associations between variables whether sleep, consumption, predicted our measures health. found significant negative correlation both ( r = −0.14, p 0.017) −0.20, < 0.001). Regression identified sole predictor outcomes, accounting 3.7% variance 1.6% anxiety. act protective risk health, underscoring its importance developing targeted interventions students.

Язык: Английский

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