A chionodracine-derived peptide, KHS-Cnd, as an anti-virulence agent against multidrug-resistant Acinetobacter baumannii clinical strains DOI Creative Commons

Marco Artini,

Irene Paris,

Esther Imperlini

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15

Опубликована: Фев. 14, 2025

About 71% of healthcare-associated infections are due to antibiotic-resistant bacteria, such as carbapenem-resistant A. baumannii , classified by World Health Organization into a critical priority group pathogens. The antimicrobial resistance profile relies on its ability produce several virulence factors, including biofilm formation. Its adhere and persist surfaces has contributed pathogenicity drug resistance. In this study, the an peptide (a chionodracine-derived named KHS-Cnd) inhibit or reduce formation was investigated example potential strategy counteract caused biofilm-forming To aim, profiles were first analyzed in selected strains, two reference six clinical all with different capability, regardless whether they resistant sensitive. Successively, we bactericidal activity that showed MIC values ranging from 5 10 µM significative antibiofilm tested strains at sub-inhibitory concentrations. fact, KHS-Cnd can hinder inhibition percentage between 65% 10%. Also statistically significant reduction mature 20% 50% observed four out eight strains. impacts various stages formation, surface-associated twitching motilities depending strain. particular, our results only possessed motility strongly impaired treatment; three instead, motility, whose for them evident after 24 h incubation peptide. Moreover, invasion pulmonary cells significantly about 32% treatment 1.25 KHS-Cnd. Finally, when used together ceftazidime/avibactam against it able minimal inhibitory concentration antibiotics needed microorganism growth.

Язык: Английский

A chionodracine-derived peptide, KHS-Cnd, as an anti-virulence agent against multidrug-resistant Acinetobacter baumannii clinical strains DOI Creative Commons

Marco Artini,

Irene Paris,

Esther Imperlini

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15

Опубликована: Фев. 14, 2025

About 71% of healthcare-associated infections are due to antibiotic-resistant bacteria, such as carbapenem-resistant A. baumannii , classified by World Health Organization into a critical priority group pathogens. The antimicrobial resistance profile relies on its ability produce several virulence factors, including biofilm formation. Its adhere and persist surfaces has contributed pathogenicity drug resistance. In this study, the an peptide (a chionodracine-derived named KHS-Cnd) inhibit or reduce formation was investigated example potential strategy counteract caused biofilm-forming To aim, profiles were first analyzed in selected strains, two reference six clinical all with different capability, regardless whether they resistant sensitive. Successively, we bactericidal activity that showed MIC values ranging from 5 10 µM significative antibiofilm tested strains at sub-inhibitory concentrations. fact, KHS-Cnd can hinder inhibition percentage between 65% 10%. Also statistically significant reduction mature 20% 50% observed four out eight strains. impacts various stages formation, surface-associated twitching motilities depending strain. particular, our results only possessed motility strongly impaired treatment; three instead, motility, whose for them evident after 24 h incubation peptide. Moreover, invasion pulmonary cells significantly about 32% treatment 1.25 KHS-Cnd. Finally, when used together ceftazidime/avibactam against it able minimal inhibitory concentration antibiotics needed microorganism growth.

Язык: Английский

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