Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 8, 2023
Abstract
Pesticide
pollution
in
aquatic
ecosystems
poses
a
prevalent
and
pressing
concern,
with
particular
emphasis
on
developing
nations.
The
effect
of
cypermethrin
(CP),
synthetic
type
II
pyrethroid
pesticide,
phenotypic
traits,
enzyme
activities,
biochemical
nutrients
freshwater,
mrigal
fish
(
Cirrhinus
mrigala
)
was
investigated
this
study.
Fingerlings
were
exposed
to
CP
concentrations
0.0065,
0.013,
0.026
ppm
determine
the
median
lethal
concentration
(LC50)
for
32
hours
subsequently,
three
sub-lethal
0.0026
ppm,
0.0013
0.00065
employed
analyze
chronic
toxicity
stress
6
weeks.
Fish
fingerlings
tolerated
well
at
lower
(0.0065
ppm)
over
exposure
times,
while
50%
mortality
occurred
0.13
after
4
exposure,
respectively.
In
present
investigation,
growth
eye
diameter
showed
marked
differences
among
treatments,
remaining,
total
length
(TL),
standard
(SL),
head
(HL),
tail
length,
width
(HW),
body
depth
(BD),
area
(BA)
dressing
percentage
(DP)
found
similar
treatments.
This
study
revealed
that
amylase
protease
activities
decreased
significantly
increasing
CP.
On
other
hand,
(protein,
lipid,
moisture,
ash)
treatments
similar.
proves
short-time
has
negative
impact
enzymatic
however,
further
studies,
such
as
metabolomic
approaches
are
required
fully
explore
during
exposures.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
Thiacloprid
(THI)
is
a
synthetic
insecticide,
the
misuse
targeted
chiefly
to
control
aphid
pest
species
in
orchards
and
vegetables.
Melatonin
(MET)
hormone
that
plays
crucial
physiological
roles
anti-inflammatory
capacities
of
fish.
We
explored
function
MET
(100
μM)
mitigate
toxicity
induced
by
THI
(20
lymphocytes.
Our
results
indicate
led
notable
rise
lymphocyte
mortality.
Lymphocytes
exposed
exhibited
heightened
incidence
pyroptosis,
accompanied
upregulation
expression
associated
with
pyroptosis
(NLRP3,
GSDMEA,
IL-18).
Meanwhile,
exposure
decrease
mitochondrial
membrane
potential,
an
increase
mtROS
levels,
reduction
intracellular
ATP,
DNA,
NADPH/NADP+
indicating
imbalance
metabolism
within
Additionally,
these
effects
were
reversed
treatment,
where
MitoQ
treatment
showed
suppression
reduced
caused
via
mtROS/cGAS-STING/NF-κB
axis.
Importantly,
provided
defense
against
immunotoxic
impacts
ameliorating
enhancing
capability
research
potentiates
safeguarding
cultured
fish
from
biological
hazards
highlights
valuable
application
common
carp.
