Cannabinoid-mediated targeting of mitochondria on the modulation of mitochondrial function and dynamics DOI Creative Commons
R.F. Malheiro, Helena Carmo, Félix Carvalho

и другие.

Pharmacological Research, Год журнала: 2022, Номер 187, С. 106603 - 106603

Опубликована: Дек. 11, 2022

Mitochondria play a critical role in the regulation of several biological processes (e.g., programmed cell death, inflammation, neurotransmission, differentiation). In recent years, accumulating findings have evidenced that cannabinoids, group endogenous and exogenous (synthetic plant-derived) psychoactive compounds bind to cannabinoid receptors, may modulate mitochondrial function dynamics. As such, mitochondria gained increasing interest as central mediators cannabinoids' pharmacological toxicological signatures. Here, we review mechanisms underlying modulation activity dynamics, well potential implications such processes' disruption on homeostasis disease. Interestingly, cannabinoids target different intracellular calcium levels, bioenergetic metabolism, apoptosis, including fission fusion, transport, mitophagy, biogenesis), by modulating multiple complex signaling pathways. Of note, outcome depend experimental models used, chemical structure, concentration, exposure settings cannabinoid, originating equivocal data. Notably, this interaction seems represent not only an important feature signatures, with for onset distinct pathological conditions cancer, neurodegenerative diseases, metabolic syndromes), but also opportunity develop novel therapeutic strategies pathologies, which is discussed review.

Язык: Английский

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases DOI Creative Commons
Jian Sheng Loh, Wen Qi Mak, Li Tan

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Язык: Английский

Процитировано

219
Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease DOI Creative Commons

Zhijun He,

Xiaoqian Li, Zi Wang

и другие.

Redox Biology, Год журнала: 2023, Номер 66, С. 102848 - 102848

Опубликована: Авг. 12, 2023

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by the deposition of β-amyloid (Aβ) peptides and dysfunction mitochondrion, which result in neuronal apoptosis ultimately cognitive impairment. Inhibiting Aβ generation repairing mitochondrial damage are prominent strategies AD therapeutic treatment. Luteolin, flavonoid compound, exhibits anti-inflammatory neuroprotective properties mice. However, it still unclear whether luteolin has any effect on pathology dysfunction. In this study, beneficial underlying mechanism were investigated triple transgenic (3 × Tg-AD) mice primary neurons. Our study showed that supplement significantly ameliorated memory impairment exerted neuroprotection inhibiting generation, reducing apoptosis. Further research revealed could directly bind with peroxisome proliferator-activated receptor gama (PPARγ) to promote its expression function. culture hippocampus-derived neurons, addition PPARγ antagonist GW9662 or knockdown siRNA eliminate pathologies. summary, work for first time effectively improved deficits 3 Tg-AD inhibited Aβ-induced oxidative stress, via PPARγ-dependent mechanism. Hence, potential serve as agent against AD.

Язык: Английский

Процитировано

66
TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury DOI
Hao Zhou,

Zhe Dai,

Jialei Li

и другие.

Metabolism, Год журнала: 2023, Номер 140, С. 155383 - 155383

Опубликована: Янв. 2, 2023

Язык: Английский

Процитировано

55
Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease DOI Creative Commons
Qing Yin Zheng, Hanghang Liu,

Hao Zhang

и другие.

Advanced Science, Год журнала: 2023, Номер 10(22)

Опубликована: Май 18, 2023

Abstract Mitochondrial dysfunction of neurons is the core pathogenesis incurable Parkinson's disease (PD). It crucial to ameliorate mitochondrial for boosting therapy PD. Herein, remarkable promotion biogenesis and improve treatment PD by using mitochondria‐targeted biomimetic nanoparticles, which are Cu 2‐ x Se‐based nanoparticles functionalized with curcumin wrapped DSPE‐PEG 2000 ‐TPP‐modified macrophage membrane (denoted as CSCCT NPs), reported. These can efficiently target mitochondria damaged in an inflammatory environment, mediate signaling pathway NAD + /SIRT1/PGC‐1 α /PPAR γ /NRF1/TFAM alleviate 1‐methyl‐4‐phenylpyridinium (MPP )‐induced neuronal toxicity. They reduce reactive oxygen species, restore potential (MMP), protect integrity respiratory chain, via promoting biogenesis, synergistically motor disorders anxiety behavior 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced mice. This study demonstrates that targeting has a great mitochondria‐related diseases.

Язык: Английский

Процитировано

45
Mitochondrial quality control in human health and disease DOI Creative Commons
Bohao Liu,

Chen-Zhen Xu,

Yi Liu

и другие.

Military Medical Research, Год журнала: 2024, Номер 11(1)

Опубликована: Май 29, 2024

Abstract Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable vital life processes such cell proliferation, differentiation, immune responses, and redox balance. In response to various physiological signals or external stimuli, sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key like biogenesis, dynamics, mitophagy, which have garnered increasing attention from researchers unveil specific molecular mechanisms. this review, we present comprehensive summary of primary mechanisms functions regulators involved major components MQC. Furthermore, critical regulated by MQC its diverse roles progression systemic diseases been described detail. We discuss agonists antagonists targeting MQC, aiming explore potential therapeutic research prospects enhancing stabilize function.

Язык: Английский

Процитировано

29
Disentangling Mitochondria in Alzheimer’s Disease DOI Open Access
Ashu Johri

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(21), С. 11520 - 11520

Опубликована: Окт. 26, 2021

Alzheimer’s disease (AD) is a major cause of dementia in older adults and fast becoming societal economic burden due to an increase life expectancy. Age seems be the factor driving AD, currently, only symptomatic treatments are available. AD has complex etiology, although mitochondrial dysfunction, oxidative stress, inflammation, metabolic abnormalities have been widely deeply investigated as plausible mechanisms for its neuropathology. Aβ plaques hyperphosphorylated tau aggregates, along with cognitive deficits behavioral problems, hallmarks disease. Restoration bioenergetics, prevention diet exercise seem effective reducing ameliorating learning memory problems. Many mitochondria-targeted antioxidants tested currently development. However, larger streamlined clinical studies needed provide hard evidence benefits AD. This review discusses causative factors, well potential therapeutics employed treatment

Язык: Английский

Процитировано

60
Punicic Acid and Its Role in the Prevention of Neurological Disorders: A Review DOI Creative Commons

Claudia M. Guerra-Vázquez,

Mariana Martínez‐Ávila, Daniel Guajardo‐Flores

и другие.

Foods, Год журнала: 2022, Номер 11(3), С. 252 - 252

Опубликована: Янв. 18, 2022

Millions of people worldwide are affected by neurodegenerative diseases (NDs). NDs characterized progressive damage and death nerve cells accompanied high levels inflammatory biomarkers oxidative stress conditions. Punicic acid, the main bioactive component pomegranate (

Язык: Английский

Процитировано

43
The Role of PGC-1α-Mediated Mitochondrial Biogenesis in Neurons DOI
Mengjie Chen,

Ru-Yu Yan,

Jian-Sheng Luo

и другие.

Neurochemical Research, Год журнала: 2023, Номер 48(9), С. 2595 - 2606

Опубликована: Апрель 25, 2023

Язык: Английский

Процитировано

26
A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study DOI Open Access

Simona Terzo,

Antonella Amato, Antonio Magán‐Fernández

и другие.

Nutrients, Год журнала: 2023, Номер 15(2), С. 462 - 462

Опубликована: Янв. 16, 2023

Pre-obesity is a condition that predisposes to the risk of developing obesity, cardiovascular diseases (CVD), and diabetes. Our previous study demonstrated Cynara cardunculus (L.) based nutraceutical named Altilix® (Bionap, Italy), containing chlorogenic acid luteolin extracts, was able improve several hepatic cardio-metabolic parameters. Given this background, we conducted post-hoc analysis in order analyze supplement’s effects subgroup pre-obesity subjects on anthropometry (weight waist circumference), glucose metabolism (HbA1C, HOMA-IR, HOMA-β), lipid profile (total cholesterol, triglycerides, LDL-cholesterol HDL-cholesterol), functionality (FLI, AST, ALT AST/ALT), carotid-media thickness (CIMT) endothelial function (FMD). Fifty from original cohort (which consisted 100 subjects) were chosen with BMI ≥ 25 < 30 kg/m2. All received supplement (150 mg/day) or placebo using computer-based random allocation system. After six months treatment significantly reduced body weight, glycemic, parameters LDL-cholesterol) improved functionality, CIMT, FMD. In conclusion, these results confirm supplementation has significant effect cardiometabolic not only obese but also subjects.

Язык: Английский

Процитировано

22
Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions DOI Open Access
Victoria Bell, Theodoros Varzakas, Θεοδώρα Ψαλτοπούλου

и другие.

Nutrients, Год журнала: 2024, Номер 16(2), С. 258 - 258

Опубликована: Янв. 15, 2024

Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is congenital blood disorder characterized by considerable phenotypic diversity. It comprises group of disorders, with sickle anemia (SCA) being most prevalent serious genotype. Although there have been some systematic reviews global data, worldwide statistics regarding SCD prevalence, morbidity, mortality remain scarce. In developed countries lower number patients, cutting-edge technologies led to development new treatments. However, developing settings where (SCD) more prevalent, medical management, rather than cure, still relies on use hydroxyurea, transfusions, analgesics. This that affects red cells, consequently affecting organs diverse manners. We discuss its etiology advent technologies, but aim this study understand various types nutrition-related studies involving individuals suffering from SCD, particularly Africa. The interplay environment, food, gut microbiota, along their respective genomes collectively known as microbiome, host metabolism responsible for mediating metabolic phenotypes modulating microbiota. addition, it serves purpose providing essential nutrients. Moreover, engages direct interactions homeostasis immune system, well indirect via metabolites. Nutrition interventions nutritional care are mechanisms addressing increased nutrient expenditures important aspects supportive management patients SCD. Underprivileged areas Sub-Saharan Africa should be accompanied efforts define promote Their importance key maintaining well-being quality life, especially because products limited, while native medicinal plant resources acknowledged.

Язык: Английский

Процитировано

14